# Calculation results of IVW methods

<br>

| exposure                                                                                                                                                                              | method                    | nsnp | b        | se       | pval     | adjust\_FDR | lo\_ci   | up\_ci   | or       | or\_lci95   | or\_uci95   |
| ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ------------------------- | ---- | -------- | -------- | -------- | ----------- | -------- | -------- | -------- | ----------- | ----------- |
| GCST003262-Post bronchodilator FEV1                                                                                                                                                   | Inverse variance weighted | 176  | 0.279157 | 0.019826 | 5.03E-45 | 9.67051E-43 | 0.240298 | 0.318017 | 1.322015 | 1.271627515 | 1.374399518 |
| GCST003264-Post bronchodilator FEV1/FVC ratio                                                                                                                                         | Inverse variance weighted | 196  | 1.049571 | 0.090403 | 3.67E-31 | 6.09372E-29 | 0.872382 | 1.22676  | 2.856425 | 2.392602739 | 3.410161476 |
| GCST006904-Cerebral amyloid deposition (PET imaging)                                                                                                                                  | Inverse variance weighted | 21   | 7.369593 | 0.681784 | 3.11E-27 | 4.90451E-25 | 6.033296 | 8.705891 | 1586.988 | 417.0876002 | 6038.376779 |
| GCST007321-Family history of Alzheimer's disease                                                                                                                                      | Inverse variance weighted | 7    | 0.022232 | 0.002214 | 9.8E-24  | 1.46987E-21 | 0.017894 | 0.026571 | 1.022481 | 1.018054741 | 1.026927068 |
| GCST005316-Intelligence (MTAG)                                                                                                                                                        | Inverse variance weighted | 434  | -0.39798 | 0.045414 | 1.89E-18 | 2.42529E-16 | -0.487   | -0.30897 | 0.671673 | 0.614469573 | 0.734200819 |
| GCST006568-Highest math class taken (MTAG)                                                                                                                                            | Inverse variance weighted | 691  | -0.43051 | 0.058559 | 1.96E-13 | 2.35969E-11 | -0.54529 | -0.31573 | 0.650177 | 0.579675655 | 0.729253844 |
| GCST006571-Educational attainment (MTAG)                                                                                                                                              | Inverse variance weighted | 862  | -0.44245 | 0.062821 | 1.88E-12 | 2.14046E-10 | -0.56558 | -0.31932 | 0.642459 | 0.568029676 | 0.726639844 |
| GCST006570-Cognitive performance (MTAG)                                                                                                                                               | Inverse variance weighted | 380  | -0.41565 | 0.059845 | 3.77E-12 | 4.06814E-10 | -0.53294 | -0.29835 | 0.659912 | 0.586874288 | 0.742038631 |
| GCST006250-Intelligence                                                                                                                                                               | Inverse variance weighted | 342  | -0.00141 | 0.000203 | 4.44E-12 | 4.71098E-10 | -0.0018  | -0.00101 | 0.998596 | 0.998198734 | 0.998993283 |
| GCST006269-General cognitive ability                                                                                                                                                  | Inverse variance weighted | 249  | -0.00146 | 0.000232 | 2.75E-10 | 2.82178E-08 | -0.00192 | -0.00101 | 0.998538 | 0.998084574 | 0.998991809 |
| GCST006442-Educational attainment (years of education)                                                                                                                                | Inverse variance weighted | 1009 | -0.37122 | 0.062603 | 3.03E-09 | 3.00875E-07 | -0.49392 | -0.24852 | 0.689891 | 0.610227014 | 0.779955054 |
| GCST006569-Self-reported math ability (MTAG)                                                                                                                                          | Inverse variance weighted | 472  | -0.35959 | 0.062799 | 1.03E-08 | 9.72793E-07 | -0.48267 | -0.2365  | 0.697965 | 0.617132114 | 0.789386389 |
| GCST003676-Educational attainment (years of education)                                                                                                                                | Inverse variance weighted | 89   | -0.56287 | 0.123423 | 5.1E-06  | 0.000407439 | -0.80478 | -0.32096 | 0.56957  | 0.44718523  | 0.725449799 |
| GCST007141-Low density lipoprotein cholesterol levels                                                                                                                                 | Inverse variance weighted | 160  | 0.645374 | 0.145782 | 9.56E-06 | 0.000743629 | 0.359643 | 0.931106 | 1.906701 | 1.432817175 | 2.537314171 |
| GCST006572-Cognitive performance                                                                                                                                                      | Inverse variance weighted | 126  | -0.42677 | 0.099578 | 1.82E-05 | 0.001381722 | -0.62195 | -0.2316  | 0.652611 | 0.53689828  | 0.793261394 |
| GCST006940-Neurociticism                                                                                                                                                              | Inverse variance weighted | 103  | 0.001602 | 0.000379 | 2.38E-05 | 0.001783986 | 0.000859 | 0.002345 | 1.001603 | 1.000859315 | 1.002347644 |
| GCST007434-Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)                                                                          | Inverse variance weighted | 17   | 0.007806 | 0.001963 | 6.98E-05 | 0.0047492   | 0.003959 | 0.011653 | 1.007836 | 1.003966463 | 1.01172073  |
| GCST006574-Highest math class taken                                                                                                                                                   | Inverse variance weighted | 208  | -0.32618 | 0.082322 | 7.42E-05 | 0.004960467 | -0.48754 | -0.16483 | 0.721672 | 0.614138114 | 0.848034818 |
| GCST004988-Breast cancer                                                                                                                                                              | Inverse variance weighted | 197  | -0.08767 | 0.023034 | 0.000141 | 0.009163242 | -0.13282 | -0.04253 | 0.916059 | 0.875622694 | 0.958363453 |
| GCST004233-LDL cholesterol levels                                                                                                                                                     | Inverse variance weighted | 41   | -0.25703 | 0.06759  | 0.000143 | 0.009163242 | -0.3895  | -0.12455 | 0.773346 | 0.677392446 | 0.882891614 |
| GCST004570-Iron status biomarkers (iron levels)                                                                                                                                       | Inverse variance weighted | 3    | -0.25466 | 0.069149 | 0.000231 | 0.014623686 | -0.39019 | -0.11913 | 0.775181 | 0.676927201 | 0.887694976 |
| GCST005931-Glioma                                                                                                                                                                     | Inverse variance weighted | 3    | -0.13156 | 0.036196 | 0.000278 | 0.017230494 | -0.20251 | -0.06062 | 0.876725 | 0.816681557 | 0.941182583 |
| GCST005932-Glioblastoma                                                                                                                                                               | Inverse variance weighted | 3    | -0.10592 | 0.029155 | 0.00028  | 0.017230494 | -0.16306 | -0.04877 | 0.899499 | 0.849539787 | 0.952397206 |
| GCST005232-Neuroticism                                                                                                                                                                | Inverse variance weighted | 77   | 0.001278 | 0.000368 | 0.000507 | 0.029152979 | 0.000558 | 0.001999 | 1.001279 | 1.000557818 | 1.002000851 |
| GCST007615-C-reactive protein levels                                                                                                                                                  | Inverse variance weighted | 36   | -1.39524 | 0.410642 | 0.00068  | 0.038684195 | -2.20009 | -0.59038 | 0.247774 | 0.110792665 | 0.554117252 |
| GCST004435-Monokine induced by gamma interferon levels                                                                                                                                | Inverse variance weighted | 2    | 0.259817 | 0.078717 | 0.000965 | 0.05295436  | 0.105531 | 0.414103 | 1.296693 | 1.111300435 | 1.513013621 |
| GCST007143-Total cholesterol levels                                                                                                                                                   | Inverse variance weighted | 184  | 0.485408 | 0.15024  | 0.001234 | 0.065408478 | 0.190937 | 0.779879 | 1.624838 | 1.210382801 | 2.181208543 |
| GCST002650-Coffee consumption (cups per day)                                                                                                                                          | Inverse variance weighted | 4    | 0.322924 | 0.100846 | 0.001364 | 0.071068481 | 0.125266 | 0.520582 | 1.38116  | 1.133450079 | 1.683006311 |
| GCST001808-Tumor biomarkers                                                                                                                                                           | Inverse variance weighted | 7    | 0.132285 | 0.041352 | 0.001379 | 0.071205297 | 0.051235 | 0.213334 | 1.141433 | 1.052570182 | 1.237798237 |
| GCST006476-Neuroticism                                                                                                                                                                | Inverse variance weighted | 206  | 0.000818 | 0.000256 | 0.00139  | 0.071205297 | 0.000316 | 0.001319 | 1.000818 | 1.000316473 | 1.001320221 |
| GCST005867-Menarche (age at onset)                                                                                                                                                    | Inverse variance weighted | 8    | -0.16084 | 0.050848 | 0.00156  | 0.07736135  | -0.26051 | -0.06118 | 0.851425 | 0.770661042 | 0.940652196 |
| GCST006480-Glioblastoma (age-stratified)                                                                                                                                              | Inverse variance weighted | 4    | -0.08607 | 0.027464 | 0.001725 | 0.082621636 | -0.1399  | -0.03224 | 0.917528 | 0.869443876 | 0.968272002 |
| GCST000653-Age-related macular degeneration                                                                                                                                           | Inverse variance weighted | 2    | 0.216074 | 0.06896  | 0.001728 | 0.082621636 | 0.080912 | 0.351236 | 1.241194 | 1.084275563 | 1.420821954 |
| GCST004389-Circulating chemerin levels                                                                                                                                                | Inverse variance weighted | 4    | -0.50294 | 0.16187  | 0.00189  | 0.086696084 | -0.8202  | -0.18567 | 0.604751 | 0.440342574 | 0.830544677 |
| GCST006573-Self-reported math ability                                                                                                                                                 | Inverse variance weighted | 310  | -0.23406 | 0.07559  | 0.001959 | 0.08854082  | -0.38222 | -0.0859  | 0.791314 | 0.682346858 | 0.917682751 |
| GCST006478-Worry                                                                                                                                                                      | Inverse variance weighted | 83   | 0.481061 | 0.157411 | 0.002243 | 0.09778175  | 0.172535 | 0.789587 | 1.617789 | 1.188312837 | 2.202486155 |
| GCST007709-General factor of neuroticism                                                                                                                                              | Inverse variance weighted | 160  | -0.40762 | 0.134228 | 0.002391 | 0.103535374 | -0.67071 | -0.14453 | 0.665232 | 0.511346985 | 0.865427372 |
| GCST002474-Glioma (high-grade)                                                                                                                                                        | Inverse variance weighted | 2    | -0.12487 | 0.041153 | 0.002412 | 0.103707803 | -0.20553 | -0.0442  | 0.882616 | 0.81421923  | 0.956758224 |
| GCST006630-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 55   | -0.05891 | 0.019661 | 0.002731 | 0.11427313  | -0.09745 | -0.02038 | 0.942788 | 0.907147623 | 0.979827865 |
| GCST002721-Trans fatty acid levels                                                                                                                                                    | Inverse variance weighted | 22   | -3.46395 | 1.159465 | 0.002812 | 0.115268303 | -5.7365  | -1.1914  | 0.031306 | 0.003226041 | 0.30379701  |
| GCST000043-Type 1 diabetes                                                                                                                                                            | Inverse variance weighted | 4    | 0.037358 | 0.012543 | 0.002897 | 0.116405583 | 0.012774 | 0.061941 | 1.038064 | 1.012856239 | 1.063899884 |
| GCST004873-Endometriosis                                                                                                                                                              | Inverse variance weighted | 2    | -0.06968 | 0.02422  | 0.004018 | 0.153415903 | -0.11715 | -0.0222  | 0.932696 | 0.889453316 | 0.978040031 |
| GCST006944-Experiencing mood swings                                                                                                                                                   | Inverse variance weighted | 48   | 0.002008 | 0.000703 | 0.004303 | 0.160338127 | 0.000629 | 0.003386 | 1.00201  | 1.000629593 | 1.003391691 |
| GCST006661-Male-pattern baldness                                                                                                                                                      | Inverse variance weighted | 145  | -0.06937 | 0.024338 | 0.004371 | 0.161878617 | -0.11707 | -0.02166 | 0.932986 | 0.889525251 | 0.978570254 |
| GCST000506-Lung adenocarcinoma                                                                                                                                                        | Inverse variance weighted | 4    | -0.19444 | 0.068853 | 0.004744 | 0.172579466 | -0.32939 | -0.05948 | 0.823299 | 0.719363386 | 0.942250671 |
| GCST007590-Hippocampal volume                                                                                                                                                         | Inverse variance weighted | 3    | 0.004285 | 0.001551 | 0.005744 | 0.20178502  | 0.001244 | 0.007325 | 1.004294 | 1.001245019 | 1.007352247 |
| GCST006292-Response to antipsychotic treatment in schizophrenia                                                                                                                       | Inverse variance weighted | 2    | 0.009081 | 0.003294 | 0.005842 | 0.201977426 | 0.002624 | 0.015538 | 1.009122 | 1.002627519 | 1.015659121 |
| GCST008152-Weight                                                                                                                                                                     | Inverse variance weighted | 11   | -0.32838 | 0.11914  | 0.005847 | 0.201977426 | -0.56189 | -0.09486 | 0.720093 | 0.570130535 | 0.909499432 |
| GCST002155-Osteoarthritis (hip)                                                                                                                                                       | Inverse variance weighted | 2    | 0.258028 | 0.09384  | 0.005966 | 0.202637946 | 0.074102 | 0.441953 | 1.294374 | 1.076916307 | 1.555743163 |
| GCST000565-Angiotensin-converting enzyme activity                                                                                                                                     | Inverse variance weighted | 2    | -0.00254 | 0.000922 | 0.005984 | 0.202637946 | -0.00434 | -0.00073 | 0.997468 | 0.99566599  | 0.999272764 |
| GCST006948-Feeling nervous                                                                                                                                                            | Inverse variance weighted | 37   | 0.00164  | 0.000597 | 0.005999 | 0.202637946 | 0.00047  | 0.00281  | 1.001642 | 1.000470419 | 1.002814308 |
| GCST007899-Fasting blood glucose                                                                                                                                                      | Inverse variance weighted | 7    | 0.450977 | 0.165182 | 0.00633  | 0.209231789 | 0.12722  | 0.774735 | 1.569845 | 1.135666359 | 2.170016009 |
| GCST002355-Serum uric acid levels                                                                                                                                                     | Inverse variance weighted | 3    | 0.808678 | 0.299302 | 0.006895 | 0.219637014 | 0.222046 | 1.39531  | 2.244938 | 1.248628242 | 4.036225727 |
| GCST002646-Infant length                                                                                                                                                              | Inverse variance weighted | 10   | -0.26085 | 0.096959 | 0.007139 | 0.225064219 | -0.45089 | -0.07081 | 0.770397 | 0.637062068 | 0.931638721 |
| GCST004067-Hip circumference adjusted for BMI                                                                                                                                         | Inverse variance weighted | 66   | -0.22002 | 0.082292 | 0.007502 | 0.234131922 | -0.38132 | -0.05873 | 0.802499 | 0.682961178 | 0.942960464 |
| GCST007182-Two-hour glucose in pregnancy (gestational week 30-32)                                                                                                                     | Inverse variance weighted | 2    | -0.09014 | 0.034391 | 0.008768 | 0.265547856 | -0.15755 | -0.02273 | 0.913805 | 0.854238035 | 0.977524919 |
| GCST007326-Number of sexual partners                                                                                                                                                  | Inverse variance weighted | 72   | -0.33254 | 0.127252 | 0.008969 | 0.268997131 | -0.58195 | -0.08312 | 0.717103 | 0.558808354 | 0.920238307 |
| GCST004212-Height                                                                                                                                                                     | Inverse variance weighted | 12   | -2.86661 | 1.101505 | 0.009256 | 0.273589933 | -5.02556 | -0.70766 | 0.056892 | 0.006567927 | 0.492797135 |
| GCST006252-Childhood steroid-sensitive nephrotic syndrome                                                                                                                             | Inverse variance weighted | 2    | -0.04485 | 0.017365 | 0.009805 | 0.287056317 | -0.07888 | -0.01081 | 0.956144 | 0.924148525 | 0.989246345 |
| GCST000667-Smoking behavior                                                                                                                                                           | Inverse variance weighted | 3    | -0.04883 | 0.018983 | 0.01011  | 0.293181941 | -0.08603 | -0.01162 | 0.952346 | 0.917563026 | 0.988448349 |
| GCST006943-Feeling miserable                                                                                                                                                          | Inverse variance weighted | 40   | 0.001928 | 0.00076  | 0.011199 | 0.307379505 | 0.000438 | 0.003419 | 1.00193  | 1.000438339 | 1.003424409 |
| GCST000666-Smoking behavior                                                                                                                                                           | Inverse variance weighted | 4    | -0.03836 | 0.0152   | 0.011607 | 0.317148279 | -0.06815 | -0.00857 | 0.962364 | 0.934116473 | 0.991465756 |
| GCST005209-Hodgkin's lymphoma                                                                                                                                                         | Inverse variance weighted | 4    | 0.124882 | 0.049655 | 0.011903 | 0.320966023 | 0.027559 | 0.222206 | 1.133015 | 1.02794188  | 1.248828001 |
| GCST007483-Waist-to-hip ratio adjusted for BMI (additive genetic model)                                                                                                               | Inverse variance weighted | 17   | 0.604648 | 0.24154  | 0.012304 | 0.326057044 | 0.131229 | 1.078067 | 1.830609 | 1.140229335 | 2.938994303 |
| GCST004521-Autism spectrum disorder or schizophrenia                                                                                                                                  | Inverse variance weighted | 44   | 0.118133 | 0.047699 | 0.013263 | 0.34551735  | 0.024643 | 0.211623 | 1.125394 | 1.024948653 | 1.235682525 |
| GCST007342-Depression                                                                                                                                                                 | Inverse variance weighted | 55   | -0.28611 | 0.115921 | 0.01358  | 0.349413371 | -0.51332 | -0.05891 | 0.751178 | 0.598506582 | 0.942793368 |
| GCST002672-Febrile seizures                                                                                                                                                           | Inverse variance weighted | 5    | -0.0621  | 0.02516  | 0.013583 | 0.349413371 | -0.11141 | -0.01278 | 0.939791 | 0.89456979  | 0.987297421 |
| GCST007602-Smoking behaviour (cigarettes smoked per day)                                                                                                                              | Inverse variance weighted | 3    | -0.36355 | 0.147608 | 0.013781 | 0.352446548 | -0.65286 | -0.07423 | 0.695206 | 0.520555186 | 0.92845389  |
| GCST003846-Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level)                                                                                                      | Inverse variance weighted | 6    | -0.00256 | 0.001042 | 0.013949 | 0.352446548 | -0.0046  | -0.00052 | 0.997442 | 0.995407052 | 0.999480693 |
| GCST005830-Hand grip strength                                                                                                                                                         | Inverse variance weighted | 75   | 4.331559 | 1.762899 | 0.014008 | 0.352446548 | 0.876277 | 7.78684  | 76.06277 | 2.401941596 | 2408.694803 |
| GCST001917-Ovarian cancer in BRCA1 mutation carriers                                                                                                                                  | Inverse variance weighted | 3    | -0.10706 | 0.043589 | 0.014045 | 0.352446548 | -0.19249 | -0.02162 | 0.898473 | 0.824901061 | 0.978607525 |
| GCST001275-Liver enzyme levels (alanine transaminase)                                                                                                                                 | Inverse variance weighted | 2    | 0.013407 | 0.005474 | 0.01432  | 0.356220483 | 0.002678 | 0.024137 | 1.013497 | 1.002681175 | 1.024430293 |
| GCST005957-Waist-to-hip ratio adjusted for BMI (age <50)                                                                                                                              | Inverse variance weighted | 3    | -0.44422 | 0.181471 | 0.014369 | 0.356220483 | -0.7999  | -0.08854 | 0.641323 | 0.449371722 | 0.915267571 |
| GCST005180-Homeostasis model assessment of beta-cell function                                                                                                                         | Inverse variance weighted | 4    | 0.773016 | 0.316222 | 0.014504 | 0.358109954 | 0.153221 | 1.392811 | 2.16629  | 1.165582927 | 4.026151696 |
| GCST005276-Dementia with Lewy bodies                                                                                                                                                  | Inverse variance weighted | 2    | 1.311901 | 0.538562 | 0.014853 | 0.363821858 | 0.256319 | 2.367483 | 3.713225 | 1.292164585 | 10.67050023 |
| GCST000817-Height                                                                                                                                                                     | Inverse variance weighted | 106  | -0.1342  | 0.055168 | 0.014993 | 0.364337092 | -0.24233 | -0.02607 | 0.874417 | 0.784799802 | 0.974267557 |
| GCST005124-Urinary magnesium-to-creatinine ratio                                                                                                                                      | Inverse variance weighted | 2    | -0.27967 | 0.11544  | 0.015407 | 0.37023595  | -0.50594 | -0.05341 | 0.75603  | 0.602940479 | 0.947990902 |
| GCST007487-Waist-to-hip ratio adjusted for BMI (additive genetic model)                                                                                                               | Inverse variance weighted | 20   | 0.586431 | 0.242252 | 0.015489 | 0.37023595  | 0.111617 | 1.061246 | 1.797562 | 1.11808476  | 2.88996866  |
| GCST000700-Vertical cup-disc ratio                                                                                                                                                    | Inverse variance weighted | 5    | -1.91559 | 0.799204 | 0.016536 | 0.388023603 | -3.48203 | -0.34915 | 0.147255 | 0.030744978 | 0.705288791 |
| GCST007515-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 11   | 0.292527 | 0.122539 | 0.016977 | 0.392387262 | 0.052349 | 0.532704 | 1.339808 | 1.053743779 | 1.70353212  |
| GCST002321-Lipid traits                                                                                                                                                               | Inverse variance weighted | 5    | 1.84043  | 0.774684 | 0.017515 | 0.398820848 | 0.322049 | 3.358811 | 6.299248 | 1.37995264  | 28.75499061 |
| GCST006718-Alcohol use disorder (consumption score)                                                                                                                                   | Inverse variance weighted | 4    | 4.741197 | 2.0018   | 0.017862 | 0.402254806 | 0.817668 | 8.664725 | 114.5713 | 2.26521202  | 5794.853428 |
| GCST003185-Nicotine dependence                                                                                                                                                        | Inverse variance weighted | 2    | -0.5927  | 0.251206 | 0.018303 | 0.40787551  | -1.08507 | -0.10034 | 0.552831 | 0.337879515 | 0.904529979 |
| GCST002289-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 2    | -0.27369 | 0.116006 | 0.018311 | 0.40787551  | -0.50106 | -0.04632 | 0.760568 | 0.605887051 | 0.954737894 |
| GCST001907-Multiple myeloma (hyperdiploidy)                                                                                                                                           | Inverse variance weighted | 2    | -0.08871 | 0.038024 | 0.019653 | 0.429040988 | -0.16323 | -0.01418 | 0.915115 | 0.849394304 | 0.985920918 |
| GCST003961-Hippocampal volume                                                                                                                                                         | Inverse variance weighted | 2    | 0.004761 | 0.002041 | 0.019679 | 0.429040988 | 0.00076  | 0.008763 | 1.004773 | 1.000760522 | 1.008801119 |
| GCST003926-Renal underexcretion gout                                                                                                                                                  | Inverse variance weighted | 5    | 0.042992 | 0.018449 | 0.019788 | 0.429876799 | 0.006832 | 0.079152 | 1.04393  | 1.006855854 | 1.082368342 |
| GCST005829-Hand grip strength                                                                                                                                                         | Inverse variance weighted | 18   | 5.847574 | 2.516138 | 0.020124 | 0.43411339  | 0.915945 | 10.7792  | 346.3931 | 2.499134607 | 48011.89316 |
| GCST001485-Hippocampal volume                                                                                                                                                         | Inverse variance weighted | 3    | 0.000391 | 0.000169 | 0.021124 | 0.451698487 | 5.86E-05 | 0.000723 | 1.000391 | 1.000058565 | 1.000722763 |
| GCST002602-Vitamin D levels                                                                                                                                                           | Inverse variance weighted | 2    | -0.02471 | 0.01075  | 0.021508 | 0.454409391 | -0.04578 | -0.00364 | 0.975589 | 0.955248131 | 0.996362977 |
| GCST007093-Osteoarthritis                                                                                                                                                             | Inverse variance weighted | 12   | 0.299714 | 0.130561 | 0.0217   | 0.456728996 | 0.043814 | 0.555613 | 1.349473 | 1.044788508 | 1.743009391 |
| GCST006942-Feeling lonely                                                                                                                                                             | Inverse variance weighted | 5    | 0.006166 | 0.002707 | 0.022753 | 0.4709854   | 0.00086  | 0.011472 | 1.006185 | 1.000860091 | 1.01153814  |
| GCST000546-Leprosy                                                                                                                                                                    | Inverse variance weighted | 5    | -0.05844 | 0.025772 | 0.023355 | 0.481828166 | -0.10895 | -0.00793 | 0.943234 | 0.896771095 | 0.99210424  |
| GCST003605-EGFR mutation-positive lung adenocarcinoma                                                                                                                                 | Inverse variance weighted | 4    | -0.08972 | 0.039614 | 0.023515 | 0.481842204 | -0.16737 | -0.01208 | 0.914184 | 0.845890161 | 0.987992257 |
| GCST000664-Vitamin D levels                                                                                                                                                           | Inverse variance weighted | 3    | -0.08177 | 0.036142 | 0.023676 | 0.481842204 | -0.1526  | -0.01093 | 0.921488 | 0.858470387 | 0.989132285 |
| GCST003724-Bipolar disorder                                                                                                                                                           | Inverse variance weighted | 4    | 0.143504 | 0.063776 | 0.024441 | 0.486295901 | 0.018503 | 0.268506 | 1.154312 | 1.01867497  | 1.308008196 |
| GCST000550-Metabolite levels                                                                                                                                                          | Inverse variance weighted | 5    | 0.10302  | 0.046038 | 0.025241 | 0.494158288 | 0.012785 | 0.193255 | 1.108514 | 1.012866874 | 1.213192581 |
| GCST007516-Type 2 diabetes (adjusted for BMI)                                                                                                                                         | Inverse variance weighted | 9    | 0.2863   | 0.128057 | 0.02537  | 0.494158288 | 0.035308 | 0.537292 | 1.331492 | 1.035938243 | 1.711366387 |
| GCST001277-Liver enzyme levels (gamma-glutamyl transferase)                                                                                                                           | Inverse variance weighted | 19   | 0.002456 | 0.001102 | 0.025816 | 0.497551824 | 0.000296 | 0.004616 | 1.002459 | 1.000296396 | 1.004626199 |
| GCST003468-Chronic lymphocytic leukemia                                                                                                                                               | Inverse variance weighted | 11   | -0.06226 | 0.028058 | 0.026482 | 0.505620952 | -0.11726 | -0.00727 | 0.939636 | 0.88935685  | 0.992757274 |
| GCST008151-Waist circumference                                                                                                                                                        | Inverse variance weighted | 4    | -0.43972 | 0.199201 | 0.027285 | 0.512996679 | -0.83015 | -0.04928 | 0.644217 | 0.435982402 | 0.951910005 |
| GCST008160-Waist circumference                                                                                                                                                        | Inverse variance weighted | 4    | -0.43972 | 0.199201 | 0.027285 | 0.512996679 | -0.83015 | -0.04928 | 0.644217 | 0.435982402 | 0.951910005 |
| GCST006698-Parental longevity (both parents in top 10%)                                                                                                                               | Inverse variance weighted | 5    | -19.4316 | 8.813726 | 0.027475 | 0.514997155 | -36.7065 | -2.15668 | 3.64E-09 | 1.14439E-16 | 0.115708477 |
| GCST005116-Male-pattern baldness                                                                                                                                                      | Inverse variance weighted | 27   | 0.057552 | 0.026161 | 0.027812 | 0.519719859 | 0.006277 | 0.108826 | 1.05924  | 1.006296427 | 1.11496869  |
| GCST000381-Biomedical quantitative traits                                                                                                                                             | Inverse variance weighted | 2    | 0.043403 | 0.020016 | 0.030129 | 0.5386359   | 0.004171 | 0.082634 | 1.044358 | 1.004179834 | 1.08614469  |
| GCST006891-Dentate gyrus molecular layer volume                                                                                                                                       | Inverse variance weighted | 5    | 0.001969 | 0.000913 | 0.031092 | 0.552776492 | 0.000179 | 0.003758 | 1.001971 | 1.000178889 | 1.003765447 |
| GCST002829-Urate levels in overweight individuals                                                                                                                                     | Inverse variance weighted | 8    | 0.075405 | 0.035316 | 0.032751 | 0.572244589 | 0.006185 | 0.144625 | 1.07832  | 1.006203736 | 1.155605946 |
| GCST001290-Height                                                                                                                                                                     | Inverse variance weighted | 5    | -0.35471 | 0.166502 | 0.03314  | 0.576323283 | -0.68106 | -0.02837 | 0.701375 | 0.506081976 | 0.972029419 |
| GCST000582-Mean corpuscular hemoglobin concentration                                                                                                                                  | Inverse variance weighted | 2    | -0.30748 | 0.144657 | 0.033536 | 0.576999186 | -0.59101 | -0.02396 | 0.735295 | 0.553766216 | 0.976329198 |
| GCST006810-Self-reported risk-taking behaviour                                                                                                                                        | Inverse variance weighted | 16   | -0.33087 | 0.155871 | 0.033777 | 0.576999186 | -0.63638 | -0.02536 | 0.718297 | 0.529204775 | 0.974954334 |
| GCST000880-Menarche (age at onset)                                                                                                                                                    | Inverse variance weighted | 19   | -0.00311 | 0.001473 | 0.034945 | 0.581743287 | -0.00599 | -0.00022 | 0.996899 | 0.994025271 | 0.999780595 |
| GCST006898-Hypothyroidism                                                                                                                                                             | Inverse variance weighted | 6    | -0.08378 | 0.039928 | 0.035874 | 0.589720087 | -0.16204 | -0.00552 | 0.919632 | 0.850407333 | 0.994491292 |
| GCST002647-Height                                                                                                                                                                     | Inverse variance weighted | 113  | -0.10468 | 0.050002 | 0.036309 | 0.593682661 | -0.20268 | -0.00667 | 0.900616 | 0.81653981  | 0.99334921  |
| GCST002762-Optic cup area                                                                                                                                                             | Inverse variance weighted | 10   | -0.60976 | 0.293113 | 0.037499 | 0.601293244 | -1.18426 | -0.03526 | 0.543481 | 0.305972026 | 0.965355573 |
| GCST002922-Multiple myeloma and monoclonal gammopathy                                                                                                                                 | Inverse variance weighted | 3    | -0.099   | 0.04768  | 0.037863 | 0.60306162  | -0.19245 | -0.00555 | 0.905743 | 0.824934093 | 0.994468538 |
| GCST002442-Blood metabolite ratios                                                                                                                                                    | Inverse variance weighted | 39   | -0.08358 | 0.04031  | 0.03814  | 0.605908539 | -0.16258 | -0.00457 | 0.919821 | 0.849944597 | 0.995441537 |
| GCST006871-Total hippocampal volume                                                                                                                                                   | Inverse variance weighted | 8    | 0.000263 | 0.000127 | 0.039344 | 0.617175778 | 1.28E-05 | 0.000513 | 1.000263 | 1.000012823 | 1.000512741 |
| GCST004941-Dehydroepiandrosterone sulphate levels                                                                                                                                     | Inverse variance weighted | 2    | -0.491   | 0.238291 | 0.039351 | 0.617175778 | -0.95805 | -0.02395 | 0.612016 | 0.383640765 | 0.976337944 |
| GCST004386-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 3    | 0.053547 | 0.026055 | 0.039868 | 0.618965095 | 0.002478 | 0.104615 | 1.055006 | 1.002481224 | 1.110283151 |
| GCST001213-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 5    | -0.1983  | 0.096673 | 0.040243 | 0.620851337 | -0.38778 | -0.00882 | 0.820123 | 0.678561535 | 0.991217585 |
| GCST002738-Psoriasis                                                                                                                                                                  | Inverse variance weighted | 9    | -0.07063 | 0.034443 | 0.040293 | 0.620851337 | -0.13814 | -0.00313 | 0.931804 | 0.870976687 | 0.996879719 |
| GCST007430-Peak expiratory flow                                                                                                                                                       | Inverse variance weighted | 54   | 0.179826 | 0.087837 | 0.040632 | 0.624507189 | 0.007666 | 0.351986 | 1.197009 | 1.007694982 | 1.421888066 |
| GCST001227-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 8    | -0.02309 | 0.011292 | 0.04092  | 0.625676453 | -0.04522 | -0.00095 | 0.977179 | 0.955788893 | 0.999048013 |
| GCST004004-Mean corpuscular volume                                                                                                                                                    | Inverse variance weighted | 8    | -3.37403 | 1.651574 | 0.04106  | 0.625676453 | -6.61112 | -0.13695 | 0.034251 | 0.001345329 | 0.872015654 |
| GCST007335-Age at first sexual intercourse                                                                                                                                            | Inverse variance weighted | 14   | -0.3633  | 0.178284 | 0.041573 | 0.629532339 | -0.71274 | -0.01387 | 0.695377 | 0.490300167 | 0.986230464 |
| GCST003217-Triglycerides                                                                                                                                                              | Inverse variance weighted | 5    | 6.202123 | 3.045539 | 0.041704 | 0.629966819 | 0.232866 | 12.17138 | 493.7964 | 1.262212441 | 193180.5644 |
| GCST000728-Behcet's disease                                                                                                                                                           | Inverse variance weighted | 2    | -0.07499 | 0.036912 | 0.042193 | 0.634053105 | -0.14734 | -0.00264 | 0.927752 | 0.86300176  | 0.997360218 |
| GCST000611-Height                                                                                                                                                                     | Inverse variance weighted | 7    | -0.19835 | 0.09793  | 0.042823 | 0.637580246 | -0.39029 | -0.00641 | 0.820082 | 0.676858318 | 0.993612845 |
| GCST001463-Adiponectin levels                                                                                                                                                         | Inverse variance weighted | 3    | -0.46186 | 0.22847  | 0.043226 | 0.637580246 | -0.90966 | -0.01406 | 0.630113 | 0.402661909 | 0.986043233 |
| GCST001930-Breast cancer                                                                                                                                                              | Inverse variance weighted | 5    | -0.12293 | 0.060855 | 0.043387 | 0.637580246 | -0.2422  | -0.00365 | 0.884329 | 0.784897638 | 0.99635744  |
| GCST004364-Intelligence                                                                                                                                                               | Inverse variance weighted | 8    | -0.00281 | 0.001394 | 0.043485 | 0.637580246 | -0.00555 | -8.2E-05 | 0.99719  | 0.994469626 | 0.999917741 |
| GCST007518-Type 2 diabetes (adjusted for BMI)                                                                                                                                         | Inverse variance weighted | 9    | 0.263817 | 0.130696 | 0.043534 | 0.637580246 | 0.007652 | 0.519981 | 1.301889 | 1.007681656 | 1.681995696 |
| GCST001101-Corneal curvature                                                                                                                                                          | Inverse variance weighted | 2    | -0.25272 | 0.125721 | 0.044416 | 0.644832834 | -0.49913 | -0.0063  | 0.776687 | 0.607057153 | 0.993715443 |
| GCST004201-Gallbladder cancer                                                                                                                                                         | Inverse variance weighted | 2    | -0.07023 | 0.034946 | 0.044471 | 0.644832834 | -0.13872 | -0.00173 | 0.932181 | 0.870469439 | 0.998267416 |
| GCST001484-Head circumference (infant)                                                                                                                                                | Inverse variance weighted | 2    | -0.35691 | 0.177848 | 0.044769 | 0.646977155 | -0.70549 | -0.00833 | 0.699837 | 0.493866065 | 0.991708413 |
| GCST004241-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 3    | 0.434939 | 0.216975 | 0.04501  | 0.648059731 | 0.009669 | 0.86021  | 1.544869 | 1.0097155   | 2.363657251 |
| GCST006289-Spherical equivalent                                                                                                                                                       | Inverse variance weighted | 23   | 0.076823 | 0.038389 | 0.045377 | 0.649038567 | 0.001579 | 0.152066 | 1.07985  | 1.001580713 | 1.164236566 |
| GCST003761-Emphysema distribution in smoking                                                                                                                                          | Inverse variance weighted | 5    | -0.22645 | 0.113205 | 0.045458 | 0.649038567 | -0.44834 | -0.00457 | 0.797356 | 0.638689779 | 0.995438288 |
| GCST000663-Obesity (early onset extreme)                                                                                                                                              | Inverse variance weighted | 2    | -0.1706  | 0.085474 | 0.045945 | 0.653042254 | -0.33813 | -0.00307 | 0.843161 | 0.713105842 | 0.996936112 |
| GCST007446-vWF levels                                                                                                                                                                 | Inverse variance weighted | 10   | 0.635815 | 0.318857 | 0.046147 | 0.653042254 | 0.010856 | 1.260774 | 1.888561 | 1.010915327 | 3.528151512 |
| GCST002041-Blood trace element (Cu levels)                                                                                                                                            | Inverse variance weighted | 2    | -0.14458 | 0.072598 | 0.046418 | 0.653042254 | -0.28688 | -0.00229 | 0.865382 | 0.750604411 | 0.997710704 |
| GCST006945-Feeling guilty                                                                                                                                                             | Inverse variance weighted | 15   | -0.00198 | 0.001004 | 0.048304 | 0.67188477  | -0.00395 | -1.5E-05 | 0.99802  | 0.996058765 | 0.999985263 |
| GCST007092-Osteoarthritis of the hip or knee                                                                                                                                          | Inverse variance weighted | 12   | 0.198741 | 0.100955 | 0.048998 | 0.680005443 | 0.000869 | 0.396613 | 1.219866 | 1.00086912  | 1.486780023 |
| GCST004611-High light scatter reticulocyte count                                                                                                                                      | Inverse variance weighted | 87   | 0.135434 | 0.068926 | 0.049424 | 0.684372778 | 0.000339 | 0.27053  | 1.145034 | 1.000338608 | 1.310658553 |
| GCST001032-Caffeine consumption                                                                                                                                                       | Inverse variance weighted | 2    | 0.172782 | 0.088878 | 0.05189  | 0.706523027 | -0.00142 | 0.346983 | 1.188608 | 0.99858315  | 1.414792372 |
| GCST006802-Body mass index                                                                                                                                                            | Inverse variance weighted | 17   | -0.25966 | 0.134948 | 0.054333 | 0.718853136 | -0.52416 | 0.004834 | 0.77131  | 0.592050483 | 1.004846165 |
| GCST000450-Matrix metalloproteinase levels                                                                                                                                            | Inverse variance weighted | 2    | -0.05439 | 0.028301 | 0.054627 | 0.718853136 | -0.10986 | 0.00108  | 0.947063 | 0.89596075  | 1.001080687 |
| GCST001783-Platelet count                                                                                                                                                             | Inverse variance weighted | 3    | -0.002   | 0.001046 | 0.055279 | 0.7201875   | -0.00405 | 4.53E-05 | 0.997998 | 0.995954691 | 1.000045301 |
| GCST002234-Breast cancer                                                                                                                                                              | Inverse variance weighted | 2    | -0.12188 | 0.063656 | 0.055528 | 0.720217654 | -0.24665 | 0.002882 | 0.885251 | 0.781414784 | 1.002886144 |
| GCST001548-Male-pattern baldness                                                                                                                                                      | Inverse variance weighted | 6    | -0.04372 | 0.02298  | 0.057096 | 0.729494779 | -0.08876 | 0.00132  | 0.95722  | 0.91506236  | 1.001320445 |
| GCST004950-Breast cancer                                                                                                                                                              | Inverse variance weighted | 56   | -0.05446 | 0.028628 | 0.057135 | 0.729494779 | -0.11057 | 0.001653 | 0.946998 | 0.895324974 | 1.001653923 |
| GCST000418-Uric acid levels                                                                                                                                                           | Inverse variance weighted | 5    | 0.257957 | 0.135905 | 0.057687 | 0.731258882 | -0.00842 | 0.524331 | 1.294283 | 0.991618428 | 1.689328558 |
| GCST002119-Metabolite levels  (X-11787)                                                                                                                                               | Inverse variance weighted | 2    | -0.28021 | 0.147973 | 0.058273 | 0.736813595 | -0.57023 | 0.00982  | 0.755627 | 0.565392791 | 1.009868045 |
| GCST006095-Excessive hairiness                                                                                                                                                        | Inverse variance weighted | 2    | 0.115182 | 0.060877 | 0.058485 | 0.736813595 | -0.00414 | 0.234501 | 1.122078 | 0.995871692 | 1.264278106 |
| GCST002674-Febrile seizures (MMR vaccine-related)                                                                                                                                     | Inverse variance weighted | 4    | -0.05102 | 0.02701  | 0.058908 | 0.737608318 | -0.10396 | 0.001921 | 0.95026  | 0.901261487 | 1.001922822 |
| GCST003665-Metabolite levels (lipoprotein measures)                                                                                                                                   | Inverse variance weighted | 13   | 0.172099 | 0.091359 | 0.059596 | 0.740800397 | -0.00696 | 0.351162 | 1.187796 | 0.993060259 | 1.420717673 |
| GCST005667-Central corneal thickness                                                                                                                                                  | Inverse variance weighted | 22   | 0.002777 | 0.001474 | 0.059645 | 0.740800397 | -0.00011 | 0.005667 | 1.002781 | 0.999887079 | 1.005682979 |
| GCST002031-Primary tooth development (number of teeth)                                                                                                                                | Inverse variance weighted | 6    | -0.08218 | 0.043676 | 0.059891 | 0.740854658 | -0.16778 | 0.003424 | 0.921106 | 0.845536469 | 1.003430102 |
| GCST008077-LDL cholesterol levels                                                                                                                                                     | Inverse variance weighted | 17   | 0.005964 | 0.003201 | 0.06245  | 0.758785209 | -0.00031 | 0.012239 | 1.005982 | 0.999689788 | 1.012314175 |
| GCST002991-Pancreatic cancer                                                                                                                                                          | Inverse variance weighted | 5    | -0.1075  | 0.057839 | 0.063072 | 0.759220416 | -0.22087 | 0.00586  | 0.898073 | 0.801822764 | 1.00587739  |
| GCST004826-P wave duration                                                                                                                                                            | Inverse variance weighted | 8    | 0.012351 | 0.006647 | 0.063161 | 0.759220416 | -0.00068 | 0.02538  | 1.012428 | 0.999322563 | 1.025704952 |
| GCST000780-Protein C levels                                                                                                                                                           | Inverse variance weighted | 4    | 0.085567 | 0.046481 | 0.065637 | 0.775738448 | -0.00554 | 0.17667  | 1.089335 | 0.99447903  | 1.193237527 |
| GCST005908-Height                                                                                                                                                                     | Inverse variance weighted | 8    | -0.78146 | 0.424965 | 0.065933 | 0.775738448 | -1.61439 | 0.051472 | 0.457737 | 0.1990118   | 1.052819311 |
| GCST002222-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 39   | 0.109183 | 0.059414 | 0.066112 | 0.775738448 | -0.00727 | 0.225634 | 1.115366 | 0.992757649 | 1.253117322 |
| GCST004894-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 51   | 0.082639 | 0.044994 | 0.066261 | 0.775738448 | -0.00555 | 0.170827 | 1.086149 | 0.994465551 | 1.186285863 |
| GCST007517-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 9    | 0.233042 | 0.126949 | 0.066401 | 0.775738448 | -0.01578 | 0.481863 | 1.262434 | 0.984345202 | 1.619087292 |
| GCST002042-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 2    | 0.048033 | 0.026217 | 0.066935 | 0.775738448 | -0.00335 | 0.099419 | 1.049205 | 0.99665276  | 1.10452915  |
| GCST005934-Neuropathic pain in head and neck cancer                                                                                                                                   | Inverse variance weighted | 2    | 0.047979 | 0.026251 | 0.067594 | 0.77584087  | -0.00347 | 0.099432 | 1.049149 | 0.99653314  | 1.104542874 |
| GCST000054-Type 1 diabetes                                                                                                                                                            | Inverse variance weighted | 2    | 0.046644 | 0.025537 | 0.067766 | 0.77584087  | -0.00341 | 0.096697 | 1.047749 | 0.99659813  | 1.101526047 |
| GCST005047-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 35   | 0.077392 | 0.042405 | 0.067993 | 0.77698704  | -0.00572 | 0.160506 | 1.080465 | 0.994293988 | 1.174104741 |
| GCST001848-IgG glycosylation                                                                                                                                                          | Inverse variance weighted | 13   | 0.036126 | 0.019809 | 0.068189 | 0.777787366 | -0.0027  | 0.074951 | 1.036786 | 0.99730481  | 1.077830949 |
| GCST006119-Protein C levels                                                                                                                                                           | Inverse variance weighted | 5    | 0.094817 | 0.052349 | 0.070102 | 0.78706638  | -0.00779 | 0.197421 | 1.099458 | 0.992243409 | 1.218256355 |
| GCST001662-Generalized epilepsy                                                                                                                                                       | Inverse variance weighted | 3    | -0.06402 | 0.035352 | 0.070155 | 0.78706638  | -0.13331 | 0.005271 | 0.937986 | 0.875193128 | 1.005284633 |
| GCST006716-Alcohol use disorder (total score)                                                                                                                                         | Inverse variance weighted | 8    | 0.002409 | 0.001332 | 0.070605 | 0.788902321 | -0.0002  | 0.005021 | 1.002412 | 0.99979751  | 1.005033162 |
| GCST001923-Glomerular filtration rate                                                                                                                                                 | Inverse variance weighted | 2    | 0.020767 | 0.011522 | 0.071475 | 0.793186677 | -0.00182 | 0.04335  | 1.020985 | 0.998186399 | 1.044303433 |
| GCST002592-Neuritic plaque                                                                                                                                                            | Inverse variance weighted | 2    | 0.930297 | 0.516664 | 0.071768 | 0.794602885 | -0.08236 | 1.942959 | 2.535263 | 0.92093619  | 6.979373634 |
| GCST002686-Protein C levels                                                                                                                                                           | Inverse variance weighted | 2    | 0.08359  | 0.046623 | 0.07299  | 0.798478086 | -0.00779 | 0.174971 | 1.087183 | 0.992239168 | 1.191211227 |
| GCST007926-Medication use (antihypertensives)                                                                                                                                         | Inverse variance weighted | 2    | -0.19706 | 0.110054 | 0.07336  | 0.80110066  | -0.41277 | 0.018645 | 0.82114  | 0.661816235 | 1.018820065 |
| GCST003044-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 82   | -0.03541 | 0.01979  | 0.073554 | 0.801257021 | -0.0742  | 0.003377 | 0.965207 | 0.928484898 | 1.003382317 |
| GCST000933-C-reactive protein                                                                                                                                                         | Inverse variance weighted | 2    | 0.232782 | 0.130128 | 0.073635 | 0.801257021 | -0.02227 | 0.487833 | 1.262106 | 0.977977652 | 1.628782204 |
| GCST001916-Breast Cancer in BRCA1 mutation carriers                                                                                                                                   | Inverse variance weighted | 2    | 0.101266 | 0.056852 | 0.074876 | 0.803314363 | -0.01016 | 0.212696 | 1.106571 | 0.98988761  | 1.237009023 |
| GCST002226-Fat body mass                                                                                                                                                              | Inverse variance weighted | 2    | -0.30858 | 0.17355  | 0.075392 | 0.803314363 | -0.64874 | 0.031574 | 0.734487 | 0.522703361 | 1.032077683 |
| GCST002166-Serum protein levels (sST2)                                                                                                                                                | Inverse variance weighted | 10   | -0.08899 | 0.050102 | 0.075697 | 0.803417531 | -0.18719 | 0.009208 | 0.914853 | 0.829284527 | 1.009250417 |
| GCST006984-Takayasu arteritis                                                                                                                                                         | Inverse variance weighted | 4    | -0.07329 | 0.041274 | 0.075794 | 0.803417531 | -0.15418 | 0.00761  | 0.929334 | 0.857115372 | 1.007638682 |
| GCST004726-Vitamin D levels                                                                                                                                                           | Inverse variance weighted | 7    | -0.16368 | 0.092288 | 0.076137 | 0.804799897 | -0.34456 | 0.017207 | 0.849015 | 0.708530043 | 1.017355606 |
| GCST002216-Triglycerides                                                                                                                                                              | Inverse variance weighted | 25   | -0.05772 | 0.032591 | 0.076569 | 0.805559346 | -0.12159 | 0.006161 | 0.943918 | 0.885507947 | 1.006180307 |
| GCST002454-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 13   | 0.075227 | 0.04256  | 0.077136 | 0.805938567 | -0.00819 | 0.158645 | 1.078129 | 0.991842772 | 1.17192202  |
| GCST006697-Parental longevity (combined parental attained age, Martingale residuals)                                                                                                  | Inverse variance weighted | 17   | 4.714234 | 2.667105 | 0.077137 | 0.805938567 | -0.51329 | 9.94176  | 111.5234 | 0.598522503 | 20780.27621 |
| GCST003851-Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)                                                               | Inverse variance weighted | 10   | 0.001653 | 0.000936 | 0.077546 | 0.806693332 | -0.00018 | 0.003488 | 1.001654 | 0.999817521 | 1.003494156 |
| GCST002896-Cholesterol, total                                                                                                                                                         | Inverse variance weighted | 26   | 0.187202 | 0.107091 | 0.080452 | 0.828510216 | -0.0227  | 0.397099 | 1.20587  | 0.977559691 | 1.487503084 |
| GCST006886-Subiculum volume                                                                                                                                                           | Inverse variance weighted | 3    | 0.00282  | 0.001615 | 0.080702 | 0.829692295 | -0.00034 | 0.005985 | 1.002824 | 0.999655544 | 1.006002727 |
| GCST007815-Male-pattern baldness                                                                                                                                                      | Inverse variance weighted | 27   | -0.03913 | 0.022504 | 0.082042 | 0.837115748 | -0.08324 | 0.004974 | 0.961622 | 0.920129066 | 1.004986636 |
| GCST003542-Night sleep phenotypes                                                                                                                                                     | Inverse variance weighted | 2    | -0.01298 | 0.00747  | 0.082212 | 0.837115748 | -0.02762 | 0.001658 | 0.987101 | 0.972754002 | 1.001659779 |
| GCST006061-Atrial fibrillation                                                                                                                                                        | Inverse variance weighted | 100  | 0.046532 | 0.026799 | 0.082506 | 0.837115748 | -0.00599 | 0.099058 | 1.047632 | 0.994023737 | 1.104130354 |
| GCST003629-nicotine metabolite ratio in current smokers                                                                                                                               | Inverse variance weighted | 4    | 0.091391 | 0.052681 | 0.082777 | 0.837115748 | -0.01186 | 0.194646 | 1.095697 | 0.988206061 | 1.214880656 |
| GCST002424-C-reactive protein levels                                                                                                                                                  | Inverse variance weighted | 3    | 0.129911 | 0.075098 | 0.083651 | 0.837115748 | -0.01728 | 0.277104 | 1.138728 | 0.982867038 | 1.319304037 |
| GCST001307-Gamma glutamyl transferase levels                                                                                                                                          | Inverse variance weighted | 3    | 0.185495 | 0.107261 | 0.083741 | 0.837115748 | -0.02474 | 0.395726 | 1.203814 | 0.975566972 | 1.485461822 |
| GCST007637-Diffusing capacity of carbon monoxide                                                                                                                                      | Inverse variance weighted | 2    | 0.232999 | 0.135204 | 0.084833 | 0.837115748 | -0.032   | 0.497999 | 1.26238  | 0.968505043 | 1.64542552  |
| GCST002084-Allergic sensitization                                                                                                                                                     | Inverse variance weighted | 7    | -0.09659 | 0.056055 | 0.084859 | 0.837115748 | -0.20646 | 0.013276 | 0.907926 | 0.813457737 | 1.013364587 |
| GCST004209-Cholesterol, total                                                                                                                                                         | Inverse variance weighted | 11   | 0.262342 | 0.152421 | 0.085219 | 0.837115748 | -0.0364  | 0.561087 | 1.299972 | 0.964252403 | 1.752576801 |
| GCST008256-Diverticulitis                                                                                                                                                             | Inverse variance weighted | 2    | -0.11174 | 0.064978 | 0.085484 | 0.837115748 | -0.2391  | 0.015613 | 0.894274 | 0.787336413 | 1.015735625 |
| GCST006077-Branched-chain amino acid levels (Isoleucine)                                                                                                                              | Inverse variance weighted | 4    | 0.197103 | 0.114663 | 0.085619 | 0.837115748 | -0.02764 | 0.421842 | 1.217869 | 0.972741708 | 1.524767408 |
| GCST004564-Waist circumference adjusted for BMI in active individuals                                                                                                                 | Inverse variance weighted | 52   | -0.13627 | 0.080128 | 0.089001 | 0.857648617 | -0.29332 | 0.020778 | 0.872604 | 0.745780047 | 1.020995442 |
| GCST004146-Chronic lymphocytic leukemia                                                                                                                                               | Inverse variance weighted | 17   | -0.03608 | 0.021264 | 0.089764 | 0.858446161 | -0.07775 | 0.0056   | 0.964566 | 0.925192128 | 1.005615607 |
| GCST006887-Hippocampal subfield CA1 volume                                                                                                                                            | Inverse variance weighted | 3    | 0.001563 | 0.000923 | 0.090293 | 0.858446161 | -0.00025 | 0.003372 | 1.001564 | 0.999754433 | 1.003377465 |
| GCST007931-Medication use (HMG CoA reductase inhibitors)                                                                                                                              | Inverse variance weighted | 53   | 0.206151 | 0.121777 | 0.090482 | 0.858446161 | -0.03253 | 0.444833 | 1.228939 | 0.967992008 | 1.560229943 |
| GCST004237-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 32   | 0.689004 | 0.407034 | 0.090504 | 0.858446161 | -0.10878 | 1.48679  | 1.991731 | 0.896925677 | 4.422876878 |
| GCST004608-Granulocyte percentage of myeloid white cells                                                                                                                              | Inverse variance weighted | 111  | 0.100528 | 0.05951  | 0.091173 | 0.858446161 | -0.01611 | 0.217168 | 1.105754 | 0.984016289 | 1.242552886 |
| GCST004135-White blood cell count (eosinophil)                                                                                                                                        | Inverse variance weighted | 2    | -1.73225 | 1.02643  | 0.091478 | 0.858446161 | -3.74406 | 0.279548 | 0.176885 | 0.023657938 | 1.322532404 |
| GCST000497-Mean platelet volume                                                                                                                                                       | Inverse variance weighted | 8    | 0.783095 | 0.464786 | 0.092017 | 0.858446161 | -0.12789 | 1.694077 | 2.188235 | 0.879953863 | 5.441619222 |
| GCST004609-Monocyte percentage of white cells                                                                                                                                         | Inverse variance weighted | 114  | -0.08134 | 0.048303 | 0.092189 | 0.858446161 | -0.17602 | 0.013334 | 0.921879 | 0.838604527 | 1.013422874 |
| GCST007140-High density lipoprotein cholesterol levels                                                                                                                                | Inverse variance weighted | 169  | -0.21933 | 0.130582 | 0.093028 | 0.858446161 | -0.47527 | 0.03661  | 0.803057 | 0.621717148 | 1.037288592 |
| GCST000545-Fetal hemoglobin levels                                                                                                                                                    | Inverse variance weighted | 2    | -0.13673 | 0.081448 | 0.093206 | 0.858446161 | -0.29637 | 0.022909 | 0.872207 | 0.743514344 | 1.023173818 |
| GCST001610-Renal function-related traits (BUN)                                                                                                                                        | Inverse variance weighted | 6    | -2.14352 | 1.278521 | 0.093628 | 0.858446161 | -4.64942 | 0.362381 | 0.117241 | 0.009567129 | 1.436745929 |
| GCST001570-Chronic lymphocytic leukemia                                                                                                                                               | Inverse variance weighted | 4    | -0.05276 | 0.031611 | 0.095125 | 0.858446161 | -0.11471 | 0.0092   | 0.94861  | 0.891620452 | 1.009242463 |
| GCST005897-Low tan response                                                                                                                                                           | Inverse variance weighted | 45   | -0.02383 | 0.014285 | 0.095274 | 0.858446161 | -0.05183 | 0.004168 | 0.976452 | 0.949492917 | 1.004176744 |
| GCST006979-Heel bone mineral density                                                                                                                                                  | Inverse variance weighted | 673  | 0.059075 | 0.035428 | 0.095424 | 0.858446161 | -0.01036 | 0.128514 | 1.060855 | 0.989689091 | 1.137137797 |
| GCST002630-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 9    | -0.01058 | 0.006347 | 0.095481 | 0.858446161 | -0.02302 | 0.001859 | 0.989474 | 0.977241709 | 1.001860298 |
| GCST006622-Neonatal cytokine/chemokine levels (fetal genetic effect)                                                                                                                  | Inverse variance weighted | 6    | -0.047   | 0.028202 | 0.095613 | 0.858446161 | -0.10227 | 0.008277 | 0.954089 | 0.902781998 | 1.008311543 |
| GCST007012-Cerebrospinal fluid AB1-42 levels                                                                                                                                          | Inverse variance weighted | 2    | -1.21316 | 0.728766 | 0.095978 | 0.859497444 | -2.64154 | 0.215225 | 0.297258 | 0.0712517   | 1.240141453 |
| GCST000225-Inflammatory bowel disease                                                                                                                                                 | Inverse variance weighted | 5    | -0.05995 | 0.036266 | 0.09833  | 0.871317821 | -0.13103 | 0.011133 | 0.941814 | 0.877192961 | 1.011195631 |
| GCST006888-Hippocampal subfield CA3 volume                                                                                                                                            | Inverse variance weighted | 3    | 0.004109 | 0.00249  | 0.098988 | 0.873143545 | -0.00077 | 0.00899  | 1.004117 | 0.999227707 | 1.009030475 |
| GCST002631-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 7    | -0.02276 | 0.013806 | 0.099283 | 0.873510939 | -0.04982 | 0.004303 | 0.9775   | 0.951403179 | 1.004312086 |
| GCST008257-Diverticular disease                                                                                                                                                       | Inverse variance weighted | 2    | -0.13694 | 0.083125 | 0.099467 | 0.873510939 | -0.29987 | 0.025982 | 0.872019 | 0.740914936 | 1.026321997 |
| GCST007938-Medication use (anilides)                                                                                                                                                  | Inverse variance weighted | 4    | -0.31532 | 0.19189  | 0.10034  | 0.873510939 | -0.69142 | 0.06079  | 0.729559 | 0.500864308 | 1.062675299 |
| GCST002828-Urate levels in obese individuals                                                                                                                                          | Inverse variance weighted | 3    | 0.068259 | 0.041553 | 0.100451 | 0.873510939 | -0.01319 | 0.149704 | 1.070642 | 0.98690045  | 1.161489891 |
| GCST001698-Serum total protein level                                                                                                                                                  | Inverse variance weighted | 2    | -0.76206 | 0.46419  | 0.100652 | 0.874021667 | -1.67188 | 0.147751 | 0.466703 | 0.187894316 | 1.159224182 |
| GCST000249-Basal cell carcinoma                                                                                                                                                       | Inverse variance weighted | 2    | 0.077001 | 0.046953 | 0.101009 | 0.87465554  | -0.01503 | 0.169029 | 1.080044 | 0.985086537 | 1.184153947 |
| GCST006924-Loneliness (MTAG)                                                                                                                                                          | Inverse variance weighted | 9    | 1.102958 | 0.673366 | 0.101426 | 0.875041297 | -0.21684 | 2.422755 | 3.013066 | 0.805059587 | 11.27688615 |
| GCST000303-Glycated hemoglobin levels                                                                                                                                                 | Inverse variance weighted | 3    | 0.453206 | 0.276737 | 0.101489 | 0.875041297 | -0.0892  | 0.995611 | 1.573349 | 0.914663832 | 2.706377779 |
| GCST003364-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 3    | 0.119857 | 0.073206 | 0.101577 | 0.875041297 | -0.02363 | 0.263342 | 1.127336 | 0.976650168 | 1.301271267 |
| GCST004574-Skin aging (microtopography measurement)                                                                                                                                   | Inverse variance weighted | 4    | -0.15106 | 0.092317 | 0.101777 | 0.875041297 | -0.332   | 0.029883 | 0.859798 | 0.717488985 | 1.030334026 |
| GCST004495-BMI (adjusted for smoking behaviour)                                                                                                                                       | Inverse variance weighted | 38   | -0.2288  | 0.140879 | 0.104361 | 0.881471377 | -0.50492 | 0.047325 | 0.795489 | 0.603553386 | 1.048463019 |
| GCST001215-Coffee consumption                                                                                                                                                         | Inverse variance weighted | 3    | 0.257978 | 0.159133 | 0.104984 | 0.885382768 | -0.05392 | 0.569878 | 1.294311 | 0.947506718 | 1.768051731 |
| GCST002598-Educational attainment                                                                                                                                                     | Inverse variance weighted | 3    | -0.59616 | 0.370528 | 0.107627 | 0.89781386  | -1.3224  | 0.130073 | 0.550922 | 0.26649588  | 1.138911294 |
| GCST001381-Menopause (age at onset)                                                                                                                                                   | Inverse variance weighted | 15   | -0.02794 | 0.017383 | 0.108026 | 0.898040745 | -0.06201 | 0.006134 | 0.97245  | 0.939877088 | 1.006152661 |
| GCST006421-Cannabis use                                                                                                                                                               | Inverse variance weighted | 3    | -0.28351 | 0.176468 | 0.108145 | 0.898040745 | -0.62939 | 0.062366 | 0.753134 | 0.532917179 | 1.064351984 |
| GCST006231-Mean arterial pressure                                                                                                                                                     | Inverse variance weighted | 24   | -0.01531 | 0.009537 | 0.108384 | 0.898040745 | -0.03401 | 0.003381 | 0.984804 | 0.966566029 | 1.003386757 |
| GCST004777-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 21   | -0.02488 | 0.015517 | 0.108877 | 0.899820473 | -0.05529 | 0.005536 | 0.975429 | 0.946209535 | 1.0055509   |
| GCST001116-Progressive supranuclear palsy                                                                                                                                             | Inverse variance weighted | 5    | -0.02256 | 0.014095 | 0.109489 | 0.903542975 | -0.05018 | 0.005067 | 0.977694 | 0.951054991 | 1.005079928 |
| GCST004144-Thyroid cancer                                                                                                                                                             | Inverse variance weighted | 5    | -0.03752 | 0.023452 | 0.109661 | 0.903749165 | -0.08348 | 0.008449 | 0.963179 | 0.919907431 | 1.008485103 |
| GCST000568-Fasting blood glucose                                                                                                                                                      | Inverse variance weighted | 9    | 0.399556 | 0.250046 | 0.11006  | 0.905355413 | -0.09054 | 0.889647 | 1.491162 | 0.913441929 | 2.434269273 |
| GCST003072-Cerebrospinal fluid AB1-42 levels                                                                                                                                          | Inverse variance weighted | 2    | 0.247184 | 0.154803 | 0.110318 | 0.905355413 | -0.05623 | 0.550598 | 1.280415 | 0.945321675 | 1.734290217 |
| GCST007445-Factor VIII levels                                                                                                                                                         | Inverse variance weighted | 9    | 0.818848 | 0.513957 | 0.11111  | 0.905391812 | -0.18851 | 1.826203 | 2.267885 | 0.828194091 | 6.210264037 |
| GCST002606-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 11   | -0.09908 | 0.062248 | 0.111455 | 0.905391812 | -0.22108 | 0.022926 | 0.905671 | 0.801649526 | 1.023191319 |
| GCST001937-Breast cancer                                                                                                                                                              | Inverse variance weighted | 47   | -0.04909 | 0.030851 | 0.111555 | 0.905391812 | -0.10956 | 0.011376 | 0.952094 | 0.896229526 | 1.01144144  |
| GCST004878-Sj?gren's syndrome                                                                                                                                                         | Inverse variance weighted | 5    | -0.04551 | 0.028616 | 0.111738 | 0.905391812 | -0.1016  | 0.010575 | 0.955509 | 0.903392801 | 1.010631614 |
| GCST006628-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 36   | 0.022256 | 0.014014 | 0.11227  | 0.905391812 | -0.00521 | 0.049724 | 1.022505 | 0.994801233 | 1.050981111 |
| GCST007018-Serum bilirubin levels in metabolic syndrome                                                                                                                               | Inverse variance weighted | 7    | 0.081713 | 0.051459 | 0.112306 | 0.905391812 | -0.01915 | 0.182573 | 1.085144 | 0.98103473  | 1.200302075 |
| GCST002388-Serum metabolite levels                                                                                                                                                    | Inverse variance weighted | 7    | -0.0489  | 0.030824 | 0.11266  | 0.905391812 | -0.10931 | 0.011518 | 0.952278 | 0.896448622 | 1.011584211 |
| GCST004518-Waist-to-hip ratio adjusted for body mass index                                                                                                                            | Inverse variance weighted | 2    | 0.428863 | 0.270788 | 0.113248 | 0.905391812 | -0.10188 | 0.959606 | 1.53551  | 0.903136894 | 2.61066839  |
| GCST008156-Hip circumference adjusted for BMI                                                                                                                                         | Inverse variance weighted | 4    | 0.246826 | 0.155871 | 0.113301 | 0.905391812 | -0.05868 | 0.552332 | 1.279956 | 0.943007683 | 1.737300514 |
| GCST004963-Lipoprotein phospholipase A2 activity in cardiovascular disease                                                                                                            | Inverse variance weighted | 7    | 0.007966 | 0.005034 | 0.113593 | 0.905391812 | -0.0019  | 0.017833 | 1.007998 | 0.998100027 | 1.017993244 |
| GCST008260-group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP                                                                                             | Inverse variance weighted | 8    | -0.01178 | 0.007462 | 0.114406 | 0.905391812 | -0.02641 | 0.002845 | 0.988289 | 0.97394032  | 1.002849305 |
| GCST005591-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 9    | 0.101415 | 0.064514 | 0.115954 | 0.906350469 | -0.02503 | 0.227863 | 1.106736 | 0.975278373 | 1.255913198 |
| GCST000507-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 10   | -0.03952 | 0.025167 | 0.116302 | 0.907224022 | -0.08885 | 0.009803 | 0.961246 | 0.914980339 | 1.009851242 |
| GCST002195-Hormone measurements                                                                                                                                                       | Inverse variance weighted | 2    | 0.196574 | 0.125677 | 0.117788 | 0.909238942 | -0.04975 | 0.4429   | 1.217225 | 0.951465215 | 1.557216663 |
| GCST007461-Alcohol consumption (drinks per week)                                                                                                                                      | Inverse variance weighted | 56   | 0.413113 | 0.264197 | 0.117898 | 0.909238942 | -0.10471 | 0.930939 | 1.511516 | 0.900583795 | 2.536889217 |
| GCST005806-Blood protein levels                                                                                                                                                       | Inverse variance weighted | 711  | 0.008263 | 0.005286 | 0.118038 | 0.909238942 | -0.0021  | 0.018624 | 1.008297 | 0.997903866 | 1.018798454 |
| GCST004094-Prostate-specific antigen levels (conditioned on lead SNPs)                                                                                                                | Inverse variance weighted | 3    | -0.35754 | 0.229197 | 0.118766 | 0.909238942 | -0.80677 | 0.091684 | 0.699393 | 0.446297737 | 1.09601885  |
| GCST001263-Height                                                                                                                                                                     | Inverse variance weighted | 7    | -0.20593 | 0.132259 | 0.11946  | 0.909238942 | -0.46516 | 0.053295 | 0.813888 | 0.628034327 | 1.054740472 |
| GCST001873-Red blood cell traits                                                                                                                                                      | Inverse variance weighted | 3    | 0.100953 | 0.065014 | 0.120473 | 0.909997261 | -0.02647 | 0.228379 | 1.106224 | 0.973873248 | 1.256562012 |
| GCST006870-Hippocampal tail volume                                                                                                                                                    | Inverse variance weighted | 7    | 0.000958 | 0.000619 | 0.121349 | 0.911853922 | -0.00025 | 0.002171 | 1.000959 | 0.99974583  | 1.002173482 |
| GCST002086-C-reactive protein                                                                                                                                                         | Inverse variance weighted | 3    | 4.921829 | 3.180641 | 0.121759 | 0.912323135 | -1.31223 | 11.15589 | 137.2534 | 0.26921963  | 69974.47968 |
| GCST004625-Monocyte count                                                                                                                                                             | Inverse variance weighted | 104  | -0.08272 | 0.053482 | 0.121937 | 0.912323135 | -0.18754 | 0.022104 | 0.920609 | 0.828992076 | 1.022350449 |
| GCST002966-Amino acid levels                                                                                                                                                          | Inverse variance weighted | 5    | -0.25535 | 0.16594  | 0.123859 | 0.912323135 | -0.58059 | 0.069898 | 0.774649 | 0.559569153 | 1.072398596 |
| GCST006259-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 36   | -0.01248 | 0.008114 | 0.124083 | 0.912323135 | -0.02838 | 0.003425 | 0.9876   | 0.972018307 | 1.003431001 |
| GCST005186-Fasting blood glucose                                                                                                                                                      | Inverse variance weighted | 18   | 0.293661 | 0.191606 | 0.125366 | 0.91531477  | -0.08189 | 0.669208 | 1.341329 | 0.921377153 | 1.952689743 |
| GCST002364-Urinary metabolites (H-NMR features)                                                                                                                                       | Inverse variance weighted | 15   | 0.017928 | 0.01173  | 0.126422 | 0.916519849 | -0.00506 | 0.040919 | 1.018089 | 0.994949725 | 1.041767213 |
| GCST000372-Height                                                                                                                                                                     | Inverse variance weighted | 5    | 0.163143 | 0.107318 | 0.128466 | 0.923245879 | -0.0472  | 0.373487 | 1.177205 | 0.953895637 | 1.452791009 |
| GCST000652-Age-related macular degeneration                                                                                                                                           | Inverse variance weighted | 2    | 0.018806 | 0.012381 | 0.128798 | 0.923245879 | -0.00546 | 0.043073 | 1.018984 | 0.99455295  | 1.044014383 |
| GCST006890-Dentate gyrus granule cell layer volume                                                                                                                                    | Inverse variance weighted | 4    | 0.002674 | 0.001768 | 0.130478 | 0.927093268 | -0.00079 | 0.006139 | 1.002677 | 0.999208619 | 1.006157884 |
| GCST002337-Amyotrophic lateral sclerosis (sporadic)                                                                                                                                   | Inverse variance weighted | 4    | 0.015988 | 0.010575 | 0.13056  | 0.927093268 | -0.00474 | 0.036714 | 1.016116 | 0.995272666 | 1.037396394 |
| GCST006889-Hippocampal subfield CA4 volume                                                                                                                                            | Inverse variance weighted | 4    | 0.00315  | 0.002086 | 0.130943 | 0.927093268 | -0.00094 | 0.007238 | 1.003155 | 0.999062709 | 1.007264341 |
| GCST007269-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 183  | -0.01321 | 0.008746 | 0.131042 | 0.927093268 | -0.03035 | 0.003936 | 0.986881 | 0.970107785 | 1.003943318 |
| GCST007225-Varicose veins                                                                                                                                                             | Inverse variance weighted | 11   | 0.067691 | 0.044896 | 0.131621 | 0.928827253 | -0.0203  | 0.155687 | 1.070035 | 0.979900277 | 1.168460063 |
| GCST002243-Bladder cancer                                                                                                                                                             | Inverse variance weighted | 2    | -0.1277  | 0.084764 | 0.13193  | 0.928827253 | -0.29384 | 0.038437 | 0.880118 | 0.745398838 | 1.039185707 |
| GCST002745-Total bilirubin levels in HIV-1 infection                                                                                                                                  | Inverse variance weighted | 4    | 0.129831 | 0.086397 | 0.13291  | 0.93279544  | -0.03951 | 0.29917  | 1.138636 | 0.961262998 | 1.348739177 |
| GCST001231-Carotid intima media thickness                                                                                                                                             | Inverse variance weighted | 3    | -0.18304 | 0.12186  | 0.133089 | 0.932809119 | -0.42188 | 0.055808 | 0.832737 | 0.655811276 | 1.057394314 |
| GCST007044-Extremely high intelligence                                                                                                                                                | Inverse variance weighted | 18   | -0.00147 | 0.000983 | 0.133568 | 0.932809119 | -0.0034  | 0.000452 | 0.998526 | 0.996604391 | 1.000452112 |
| GCST002703-Prostate-specific antigen levels                                                                                                                                           | Inverse variance weighted | 4    | 0.11827  | 0.078857 | 0.133663 | 0.932809119 | -0.03629 | 0.27283  | 1.125548 | 0.964361792 | 1.313676499 |
| GCST002541-Menarche (age at onset)                                                                                                                                                    | Inverse variance weighted | 82   | -0.07759 | 0.051814 | 0.134276 | 0.932809119 | -0.17914 | 0.023966 | 0.925345 | 0.835986554 | 1.024255718 |
| GCST007925-Medication use (vasodilators used in cardiac diseases)                                                                                                                     | Inverse variance weighted | 2    | -0.15208 | 0.101573 | 0.134319 | 0.932809119 | -0.35117 | 0.046999 | 0.858917 | 0.703866771 | 1.048121279 |
| GCST004750-Squamous cell lung carcinoma                                                                                                                                               | Inverse variance weighted | 12   | -0.0514  | 0.034349 | 0.134547 | 0.932809119 | -0.11872 | 0.015924 | 0.949899 | 0.888053672 | 1.016051149 |
| GCST004070-Cerebrospinal P-tau181p levels                                                                                                                                             | Inverse variance weighted | 2    | 10.97812 | 7.33694  | 0.134581 | 0.932809119 | -3.40228 | 25.35852 | 58578.26 | 0.033297144 | 1.03054E+11 |
| GCST006611-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 93   | -0.39798 | 0.266374 | 0.135161 | 0.934088983 | -0.92007 | 0.124115 | 0.671678 | 0.398491622 | 1.132146482 |
| GCST007718-Urinary albumin-to-creatinine ratio                                                                                                                                        | Inverse variance weighted | 4    | 0.695021 | 0.465517 | 0.135435 | 0.934088983 | -0.21739 | 1.607434 | 2.00375  | 0.804613907 | 4.989990687 |
| GCST006911-Asthma (moderate or severe)                                                                                                                                                | Inverse variance weighted | 12   | 0.093193 | 0.06251  | 0.136003 | 0.934088983 | -0.02933 | 0.215713 | 1.097674 | 0.971098627 | 1.240746685 |
| GCST002315-Thrombin generation potential phenotypes                                                                                                                                   | Inverse variance weighted | 2    | 0.003035 | 0.002041 | 0.137074 | 0.936211431 | -0.00097 | 0.007036 | 1.00304  | 0.999034476 | 1.007060728 |
| GCST004499-BMI in non-smokers                                                                                                                                                         | Inverse variance weighted | 25   | -0.21298 | 0.14357  | 0.137957 | 0.936436206 | -0.49438 | 0.06842  | 0.808174 | 0.609951132 | 1.070814491 |
| GCST000672-Paget's disease                                                                                                                                                            | Inverse variance weighted | 2    | -0.0416  | 0.028201 | 0.140173 | 0.945820893 | -0.09688 | 0.013673 | 0.959252 | 0.907669038 | 1.013767353 |
| GCST004334-Mean corpuscular hemoglobin                                                                                                                                                | Inverse variance weighted | 4    | -0.06807 | 0.04634  | 0.141867 | 0.952049575 | -0.15889 | 0.022759 | 0.934197 | 0.853086182 | 1.023019906 |
| GCST005846-Heart rate response to recovery post exercise (10 sec)                                                                                                                     | Inverse variance weighted | 8    | -0.19043 | 0.129764 | 0.142232 | 0.952049575 | -0.44477 | 0.063905 | 0.826602 | 0.640972585 | 1.065990914 |
| GCST000527-Ulcerative colitis                                                                                                                                                         | Inverse variance weighted | 2    | 0.156914 | 0.107232 | 0.143383 | 0.955059941 | -0.05326 | 0.36709  | 1.169895 | 0.948131976 | 1.44352745  |
| GCST001969-Heart rate                                                                                                                                                                 | Inverse variance weighted | 15   | 0.016419 | 0.01125  | 0.144411 | 0.960866138 | -0.00563 | 0.038468 | 1.016555 | 0.994386087 | 1.039217973 |
| GCST001984-Graves' disease                                                                                                                                                            | Inverse variance weighted | 2    | 0.112834 | 0.077563 | 0.145739 | 0.962317284 | -0.03919 | 0.264857 | 1.119446 | 0.961569114 | 1.303244557 |
| GCST001758-Birth weight                                                                                                                                                               | Inverse variance weighted | 4    | -0.22072 | 0.151814 | 0.145981 | 0.962317284 | -0.51827 | 0.076837 | 0.801943 | 0.59554826  | 1.079865983 |
| GCST004347-Glioma                                                                                                                                                                     | Inverse variance weighted | 3    | -0.08053 | 0.055414 | 0.146157 | 0.962317284 | -0.18914 | 0.028081 | 0.922628 | 0.827670967 | 1.028479425 |
| GCST006575-Takayasu arteritis                                                                                                                                                         | Inverse variance weighted | 2    | 0.031391 | 0.021603 | 0.146195 | 0.962317284 | -0.01095 | 0.073733 | 1.031889 | 0.9891094   | 1.076518835 |
| GCST007507-Benign prostatic hyperplasia and lower urinary tract symptoms                                                                                                              | Inverse variance weighted | 10   | -0.10628 | 0.073663 | 0.149093 | 0.966905542 | -0.25066 | 0.038103 | 0.899176 | 0.778289237 | 1.038838218 |
| GCST007459-Smoking behaviour (cigarettes smoked per day)                                                                                                                              | Inverse variance weighted | 32   | -0.19875 | 0.138627 | 0.151668 | 0.973633702 | -0.47045 | 0.072965 | 0.819759 | 0.62471807  | 1.075692468 |
| GCST000818-Urate levels                                                                                                                                                               | Inverse variance weighted | 7    | 0.000971 | 0.000677 | 0.151899 | 0.973633702 | -0.00036 | 0.002298 | 1.000971 | 0.999642999 | 1.002300808 |
| GCST007266-Adult asthma                                                                                                                                                               | Inverse variance weighted | 2    | -0.07863 | 0.055054 | 0.15322  | 0.976109018 | -0.18654 | 0.029275 | 0.924381 | 0.829827453 | 1.029707907 |
| GCST008295-Number of decayed, missing and filled tooth surfaces or use of dentures                                                                                                    | Inverse variance weighted | 23   | 0.30775  | 0.215954 | 0.154137 | 0.977948857 | -0.11552 | 0.731019 | 1.36036  | 0.890902704 | 2.077197206 |
| GCST008070-HDL cholesterol levels                                                                                                                                                     | Inverse variance weighted | 28   | -0.46524 | 0.32737  | 0.155271 | 0.97942471  | -1.10689 | 0.176401 | 0.627982 | 0.330585586 | 1.192916085 |
| GCST002603-Creatine kinase in statin users                                                                                                                                            | Inverse variance weighted | 2    | -0.16957 | 0.119339 | 0.155351 | 0.97942471  | -0.40347 | 0.064338 | 0.84403  | 0.667996365 | 1.066452628 |
| GCST002921-Multiple myeloma                                                                                                                                                           | Inverse variance weighted | 2    | -0.07558 | 0.053343 | 0.156508 | 0.97942471  | -0.18014 | 0.02897  | 0.927203 | 0.835156982 | 1.029393683 |
| GCST001858-Refractive error                                                                                                                                                           | Inverse variance weighted | 14   | 0.071176 | 0.050282 | 0.156916 | 0.97942471  | -0.02738 | 0.169729 | 1.07377  | 0.97299366  | 1.184983864 |
| GCST005312-Menopause (age at onset)                                                                                                                                                   | Inverse variance weighted | 38   | -0.02412 | 0.017061 | 0.157424 | 0.97942471  | -0.05756 | 0.009319 | 0.976168 | 0.944064099 | 1.009362605 |
| GCST006624-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 80   | 0.018232 | 0.012901 | 0.157583 | 0.97942471  | -0.00705 | 0.043518 | 1.018399 | 0.992971268 | 1.04447835  |
| GCST002830-Urate levels in lean individuals                                                                                                                                           | Inverse variance weighted | 3    | 0.051421 | 0.036672 | 0.160854 | 0.985284102 | -0.02046 | 0.123298 | 1.052766 | 0.979752547 | 1.131221181 |
| GCST006475-Depressed affect                                                                                                                                                           | Inverse variance weighted | 40   | 0.30983  | 0.221139 | 0.161196 | 0.985284102 | -0.1236  | 0.743263 | 1.363193 | 0.883730351 | 2.102786625 |
| GCST003359-Serum uric acid levels                                                                                                                                                     | Inverse variance weighted | 2    | 0.001278 | 0.000913 | 0.161646 | 0.985284102 | -0.00051 | 0.003068 | 1.001279 | 0.999488376 | 1.003072398 |
| GCST001609-Lung adenocarcinoma                                                                                                                                                        | Inverse variance weighted | 3    | -0.07835 | 0.05602  | 0.161951 | 0.985284102 | -0.18815 | 0.031453 | 0.924644 | 0.828494416 | 1.031952729 |
| GCST004572-Iron status biomarkers (transferrin saturation)                                                                                                                            | Inverse variance weighted | 3    | -0.16179 | 0.11572  | 0.162085 | 0.985284102 | -0.3886  | 0.065024 | 0.850622 | 0.678006102 | 1.067184612 |
| GCST007492-Waist-to-hip ratio adjusted for BMI (additive genetic model)                                                                                                               | Inverse variance weighted | 3    | 0.600254 | 0.429657 | 0.162398 | 0.985284102 | -0.24187 | 1.442381 | 1.822581 | 0.785154861 | 4.230758628 |
| GCST002733-Platelet count                                                                                                                                                             | Inverse variance weighted | 3    | 0.002485 | 0.001779 | 0.162399 | 0.985284102 | -0.001   | 0.005972 | 1.002488 | 0.998999081 | 1.005989629 |
| GCST005213-Asthma (childhood onset)                                                                                                                                                   | Inverse variance weighted | 3    | 0.095505 | 0.068436 | 0.162849 | 0.985284102 | -0.03863 | 0.229639 | 1.100215 | 0.962108305 | 1.258145979 |
| GCST001850-Major depressive disorder                                                                                                                                                  | Inverse variance weighted | 2    | -0.06494 | 0.046554 | 0.163042 | 0.985284102 | -0.15618 | 0.026307 | 0.937125 | 0.855401661 | 1.026656073 |
| GCST007502-Waist-to-hip ratio adjusted for BMI (additive genetic model)                                                                                                               | Inverse variance weighted | 14   | 0.300291 | 0.215654 | 0.163781 | 0.985284102 | -0.12239 | 0.722972 | 1.350252 | 0.884802936 | 2.06054891  |
| GCST003383-Platelet count                                                                                                                                                             | Inverse variance weighted | 3    | -0.00304 | 0.002185 | 0.163976 | 0.985284102 | -0.00732 | 0.001241 | 0.996964 | 0.992703921 | 1.001242085 |
| GCST003925-Gout                                                                                                                                                                       | Inverse variance weighted | 6    | 0.022851 | 0.016442 | 0.164585 | 0.985284102 | -0.00937 | 0.055077 | 1.023114 | 0.990669028 | 1.056621471 |
| GCST001144-Dupuytren's disease                                                                                                                                                        | Inverse variance weighted | 6    | 0.039677 | 0.028577 | 0.165012 | 0.985284102 | -0.01633 | 0.095688 | 1.040474 | 0.983798312 | 1.100415235 |
| GCST002275-Asthma (childhood onset)                                                                                                                                                   | Inverse variance weighted | 3    | -0.03808 | 0.027552 | 0.16689  | 0.985284102 | -0.09209 | 0.015918 | 0.962632 | 0.912027268 | 1.01604497  |
| GCST007132-High density lipoprotein cholesterol levels                                                                                                                                | Inverse variance weighted | 13   | 0.507371 | 0.367508 | 0.167411 | 0.985284102 | -0.21294 | 1.227687 | 1.660919 | 0.808200949 | 3.413324313 |
| GCST005752-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 34   | 0.034041 | 0.024695 | 0.16807  | 0.985284102 | -0.01436 | 0.082444 | 1.034627 | 0.985740549 | 1.085937901 |
| GCST001105-Migraine                                                                                                                                                                   | Inverse variance weighted | 2    | -0.13311 | 0.09661  | 0.168261 | 0.985284102 | -0.32246 | 0.056245 | 0.875369 | 0.72436131  | 1.057856671 |
| GCST008235-Cognitive impairment                                                                                                                                                       | Inverse variance weighted | 2    | -1.32789 | 0.964073 | 0.168396 | 0.985284102 | -3.21747 | 0.561692 | 0.265036 | 0.040056181 | 1.753637297 |
| GCST002537-Breast cancer                                                                                                                                                              | Inverse variance weighted | 3    | -0.20119 | 0.146117 | 0.16855  | 0.985284102 | -0.48757 | 0.085204 | 0.817761 | 0.614113879 | 1.088939537 |
| GCST006477-Depression                                                                                                                                                                 | Inverse variance weighted | 47   | -0.00082 | 0.000596 | 0.169296 | 0.985284102 | -0.00199 | 0.000349 | 0.999181 | 0.998014021 | 1.000349145 |
| GCST008105-Diverticular disease                                                                                                                                                       | Inverse variance weighted | 2    | -0.2776  | 0.202037 | 0.169438 | 0.985284102 | -0.67359 | 0.118391 | 0.757599 | 0.509873387 | 1.125684517 |
| GCST002458-Serum thyroid-stimulating hormone levels                                                                                                                                   | Inverse variance weighted | 2    | 0.361532 | 0.263309 | 0.169742 | 0.985284102 | -0.15455 | 0.877617 | 1.435527 | 0.856797961 | 2.405162314 |
| GCST007876-Estimated glomerular filtration rate                                                                                                                                       | Inverse variance weighted | 80   | -0.00036 | 0.000261 | 0.169743 | 0.985284102 | -0.00087 | 0.000153 | 0.999642 | 0.999132117 | 1.000152919 |
| GCST007494-Waist-to-hip ratio adjusted for BMI (additive genetic model)                                                                                                               | Inverse variance weighted | 3    | 0.564173 | 0.411224 | 0.170083 | 0.985300405 | -0.24183 | 1.370173 | 1.757994 | 0.785192934 | 3.936029866 |
| GCST001180-Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid)                                                                                                     | Inverse variance weighted | 7    | -0.52161 | 0.380553 | 0.170477 | 0.985973678 | -1.2675  | 0.224269 | 0.593562 | 0.281535546 | 1.251408222 |
| GCST000851-Hodgkin's lymphoma                                                                                                                                                         | Inverse variance weighted | 2    | -0.0871  | 0.063639 | 0.171125 | 0.986941191 | -0.21183 | 0.037636 | 0.916589 | 0.809102742 | 1.038353699 |
| GCST000756-Magnesium levels                                                                                                                                                           | Inverse variance weighted | 4    | 0.328879 | 0.240589 | 0.171633 | 0.987559921 | -0.14268 | 0.800434 | 1.38941  | 0.867035376 | 2.226507786 |
| GCST004349-Glioblastoma                                                                                                                                                               | Inverse variance weighted | 5    | -0.04795 | 0.035085 | 0.171759 | 0.987559921 | -0.11671 | 0.020821 | 0.953184 | 0.889839292 | 1.021038859 |
| GCST007725-Serum uric acid levels                                                                                                                                                     | Inverse variance weighted | 21   | 0.11026  | 0.08073  | 0.172008 | 0.987559921 | -0.04797 | 0.268491 | 1.116568 | 0.953161004 | 1.30798976  |
| GCST001720-Endometriosis                                                                                                                                                              | Inverse variance weighted | 5    | -0.0645  | 0.047278 | 0.172452 | 0.987559921 | -0.15717 | 0.02816  | 0.937532 | 0.854560077 | 1.028560348 |
| GCST000401-Menopause (age at onset)                                                                                                                                                   | Inverse variance weighted | 3    | 0.038258 | 0.028049 | 0.172575 | 0.987559921 | -0.01672 | 0.093234 | 1.038999 | 0.983421094 | 1.097718781 |
| GCST004983-Parental lifespan                                                                                                                                                          | Inverse variance weighted | 3    | -0.76272 | 0.562386 | 0.175027 | 0.989433972 | -1.865   | 0.339553 | 0.466395 | 0.154896434 | 1.404319431 |
| GCST001784-Pulmonary function (smoking interaction)                                                                                                                                   | Inverse variance weighted | 2    | 0.979192 | 0.722116 | 0.175098 | 0.989433972 | -0.43616 | 2.394539 | 2.662303 | 0.646516797 | 10.96314402 |
| GCST001465-Adiponectin levels                                                                                                                                                         | Inverse variance weighted | 4    | -0.46765 | 0.345211 | 0.175521 | 0.989537144 | -1.14426 | 0.208965 | 0.626474 | 0.318459048 | 1.232402011 |
| GCST002493-Bone mineral density (paediatric, skull)                                                                                                                                   | Inverse variance weighted | 5    | 0.080578 | 0.059492 | 0.175599 | 0.989537144 | -0.03603 | 0.197182 | 1.083913 | 0.964614585 | 1.217966085 |
| GCST008103-Bipolar disorder                                                                                                                                                           | Inverse variance weighted | 8    | -0.11826 | 0.087412 | 0.176071 | 0.990054856 | -0.28959 | 0.053063 | 0.888461 | 0.748568156 | 1.05449647  |
| GCST004776-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 19   | -0.01059 | 0.007832 | 0.176422 | 0.990054856 | -0.02594 | 0.004763 | 0.989468 | 0.974394971 | 1.00477439  |
| GCST004131-Inflammatory bowel disease                                                                                                                                                 | Inverse variance weighted | 9    | 0.095173 | 0.070414 | 0.176496 | 0.990054856 | -0.04284 | 0.233185 | 1.099849 | 0.958066133 | 1.262615147 |
| GCST003236-Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid)                                                                                                        | Inverse variance weighted | 2    | 0.084553 | 0.06266  | 0.17721  | 0.993150215 | -0.03826 | 0.207367 | 1.088231 | 0.962462189 | 1.230434117 |
| GCST006083-Prostate cancer (advanced)                                                                                                                                                 | Inverse variance weighted | 2    | 0.221699 | 0.164834 | 0.178632 | 0.994505803 | -0.10138 | 0.544773 | 1.248195 | 0.90359306  | 1.72421735  |
| GCST003924-Renal overload gout                                                                                                                                                        | Inverse variance weighted | 4    | 0.033289 | 0.024782 | 0.17918  | 0.994505803 | -0.01528 | 0.081861 | 1.033849 | 0.984832971 | 1.085304798 |
| GCST007201-Schizophrenia                                                                                                                                                              | Inverse variance weighted | 123  | -0.03498 | 0.026054 | 0.179436 | 0.994505803 | -0.08604 | 0.016089 | 0.965627 | 0.917553551 | 1.016218896 |
| GCST006914-Sleep duration                                                                                                                                                             | Inverse variance weighted | 13   | -0.18945 | 0.141131 | 0.17947  | 0.994505803 | -0.46607 | 0.087164 | 0.827412 | 0.627464117 | 1.091075646 |
| GCST007500-Waist-to-hip ratio adjusted for BMI (additive genetic model)                                                                                                               | Inverse variance weighted | 14   | 0.302953 | 0.225693 | 0.179491 | 0.994505803 | -0.1394  | 0.74531  | 1.353851 | 0.869875974 | 2.107095521 |
| GCST007228-Pulmonary arterial hypertension                                                                                                                                            | Inverse variance weighted | 2    | -0.0552  | 0.041187 | 0.180173 | 0.994505803 | -0.13592 | 0.025527 | 0.946297 | 0.87290822  | 1.025855147 |
| GCST007923-Medication use (drugs used in diabetes)                                                                                                                                    | Inverse variance weighted | 39   | 0.06051  | 0.045282 | 0.181449 | 0.997029673 | -0.02824 | 0.149263 | 1.062379 | 0.972153061 | 1.160978199 |
| GCST002329-Acne (severe)                                                                                                                                                              | Inverse variance weighted | 2    | 0.076413 | 0.057349 | 0.182723 | 0.997029673 | -0.03599 | 0.188818 | 1.079409 | 0.964648476 | 1.207821197 |
| GCST006655-Breast size                                                                                                                                                                | Inverse variance weighted | 2    | -0.10815 | 0.081364 | 0.183768 | 0.997029673 | -0.26763 | 0.051321 | 0.897491 | 0.765194402 | 1.052660702 |
| GCST001699-Serum albumin level                                                                                                                                                        | Inverse variance weighted | 6    | 0.756664 | 0.569444 | 0.183922 | 0.997029673 | -0.35945 | 1.872773 | 2.131154 | 0.698062607 | 6.50631665  |
| GCST003220-Glioblastoma                                                                                                                                                               | Inverse variance weighted | 3    | -0.07667 | 0.05781  | 0.184764 | 0.997029673 | -0.18998 | 0.036638 | 0.926196 | 0.826977967 | 1.037317858 |
| GCST008306-Dentures                                                                                                                                                                   | Inverse variance weighted | 16   | 0.17481  | 0.132233 | 0.186174 | 0.997029673 | -0.08437 | 0.433987 | 1.19102  | 0.919093663 | 1.54339817  |
| GCST001574-Activated partial thromboplastin time                                                                                                                                      | Inverse variance weighted | 6    | 0.010099 | 0.007644 | 0.186411 | 0.997029673 | -0.00488 | 0.025081 | 1.01015  | 0.995129681 | 1.025398011 |
| GCST001840-Stearic acid (18:0) levels                                                                                                                                                 | Inverse variance weighted | 3    | 0.109678 | 0.083083 | 0.186798 | 0.997029673 | -0.05316 | 0.272521 | 1.115919 | 0.948224814 | 1.313270565 |
| GCST006491-Circulating fibroblast growth factor 23 levels                                                                                                                             | Inverse variance weighted | 4    | -0.45785 | 0.347279 | 0.187375 | 0.997029673 | -1.13851 | 0.222819 | 0.632644 | 0.320294941 | 1.249594177 |
| GCST005520-Heart rate response to beta blockers (atenolol add-on therapy)                                                                                                             | Inverse variance weighted | 5    | -0.00339 | 0.002579 | 0.188164 | 0.997029673 | -0.00845 | 0.001661 | 0.996611 | 0.991586071 | 1.001662302 |
| GCST007020-Male-pattern baldness                                                                                                                                                      | Inverse variance weighted | 400  | -0.03862 | 0.029427 | 0.189387 | 0.998583867 | -0.0963  | 0.019057 | 0.962116 | 0.908194091 | 1.019239866 |
| GCST003855-Gut microbiota (bacterial taxa)                                                                                                                                            | Inverse variance weighted | 6    | -0.00179 | 0.001368 | 0.190404 | 0.998683795 | -0.00447 | 0.00089  | 0.99821  | 0.995537063 | 1.000890518 |
| GCST001957-Obesity (early onset extreme)                                                                                                                                              | Inverse variance weighted | 6    | -0.0345  | 0.026515 | 0.193156 | 0.998683795 | -0.08647 | 0.017465 | 0.966085 | 0.917160372 | 1.017618735 |
| GCST005782-Serum 25-Hydroxyvitamin D levels                                                                                                                                           | Inverse variance weighted | 6    | -0.00111 | 0.000854 | 0.193451 | 0.998683795 | -0.00279 | 0.000563 | 0.99889  | 0.997218573 | 1.000563605 |
| GCST002545-Ossification of the posterior longitudinal ligament of the spine                                                                                                           | Inverse variance weighted | 4    | -0.04363 | 0.033677 | 0.195161 | 0.998683795 | -0.10963 | 0.022379 | 0.957311 | 0.896163062 | 1.022631734 |
| GCST006402-Energy intake                                                                                                                                                              | Inverse variance weighted | 2    | 0.000317 | 0.000246 | 0.198215 | 0.998683795 | -0.00017 | 0.000799 | 1.000317 | 0.99983423  | 1.000799676 |
| GCST006291-Spherical equivalent or myopia (age of diagnosis)                                                                                                                          | Inverse variance weighted | 72   | 0.000456 | 0.000355 | 0.198704 | 0.998683795 | -0.00024 | 0.001153 | 1.000457 | 0.999760392 | 1.001153217 |
| GCST005839-Depression                                                                                                                                                                 | Inverse variance weighted | 27   | -0.16219 | 0.126482 | 0.199722 | 0.998683795 | -0.4101  | 0.085711 | 0.850276 | 0.663584672 | 1.089491762 |
| GCST004606-Eosinophil counts                                                                                                                                                          | Inverse variance weighted | 99   | -0.06558 | 0.051207 | 0.200289 | 0.998683795 | -0.16595 | 0.034784 | 0.936522 | 0.847089918 | 1.035395624 |
| GCST006023-Hypertension                                                                                                                                                               | Inverse variance weighted | 3    | -0.00293 | 0.00229  | 0.20092  | 0.998683795 | -0.00742 | 0.00156  | 0.997076 | 0.992610487 | 1.001560815 |
| GCST003435-Body fat percentage                                                                                                                                                        | Inverse variance weighted | 7    | -4.56454 | 3.602783 | 0.205173 | 0.998683795 | -11.626  | 2.49691  | 0.010415 | 8.93086E-06 | 12.14491143 |
| GCST004147-Chronic obstructive pulmonary disease                                                                                                                                      | Inverse variance weighted | 15   | -0.05094 | 0.040267 | 0.205856 | 0.998683795 | -0.12986 | 0.027984 | 0.950336 | 0.878215917 | 1.028379138 |
| GCST007512-Benign prostatic hyperplasia and lower urinary tract symptoms (prostate cancer excluded)                                                                                   | Inverse variance weighted | 9    | -0.10103 | 0.080104 | 0.207241 | 0.998683795 | -0.25803 | 0.055977 | 0.90391  | 0.772573266 | 1.057573719 |
| GCST000708-Freckling                                                                                                                                                                  | Inverse variance weighted | 3    | -0.01857 | 0.014734 | 0.207498 | 0.998683795 | -0.04745 | 0.010307 | 0.981599 | 0.953656425 | 1.010360372 |
| GCST007236-Breast cancer                                                                                                                                                              | Inverse variance weighted | 32   | -0.04054 | 0.032248 | 0.208655 | 0.998683795 | -0.10375 | 0.022661 | 0.960267 | 0.901450957 | 1.022920031 |
| GCST003273-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 5    | -0.02123 | 0.01689  | 0.208827 | 0.998683795 | -0.05433 | 0.011877 | 0.978996 | 0.947118117 | 1.011947822 |
| GCST000612-Celiac disease                                                                                                                                                             | Inverse variance weighted | 13   | -0.03578 | 0.028561 | 0.21028  | 0.998683795 | -0.09176 | 0.020198 | 0.964851 | 0.912323544 | 1.020403779 |
| GCST005849-Heart rate response to recovery post exercise (40 sec)                                                                                                                     | Inverse variance weighted | 10   | -0.13806 | 0.110842 | 0.212917 | 0.998683795 | -0.35531 | 0.079187 | 0.871043 | 0.700952689 | 1.082407218 |
| GCST006368-Body mass index                                                                                                                                                            | Inverse variance weighted | 146  | -0.3447  | 0.277036 | 0.213405 | 0.998683795 | -0.88769 | 0.198287 | 0.70843  | 0.411604087 | 1.219311831 |
| GCST001238-Hypertension                                                                                                                                                               | Inverse variance weighted | 3    | -0.20884 | 0.167928 | 0.213646 | 0.998683795 | -0.53797 | 0.120303 | 0.811529 | 0.583930363 | 1.127838567 |
| GCST000292-Metabolic traits                                                                                                                                                           | Inverse variance weighted | 3    | 0.048919 | 0.039364 | 0.213969 | 0.998683795 | -0.02824 | 0.126073 | 1.050135 | 0.972159755 | 1.134365493 |
| GCST001679-Complement C3 and C4 levels                                                                                                                                                | Inverse variance weighted | 3    | 0.170572 | 0.137343 | 0.214258 | 0.998683795 | -0.09862 | 0.439764 | 1.185983 | 0.906086698 | 1.552340244 |
| GCST006923-Loneliness                                                                                                                                                                 | Inverse variance weighted | 7    | 1.519867 | 1.224047 | 0.214357 | 0.998683795 | -0.87926 | 3.918999 | 4.571618 | 0.41508823  | 50.34999711 |
| GCST005076-Breast cancer (estrogen-receptor negative)                                                                                                                                 | Inverse variance weighted | 19   | -0.05102 | 0.041166 | 0.215194 | 0.998683795 | -0.13171 | 0.029664 | 0.950258 | 0.876598563 | 1.030108026 |
| GCST007217-RR interval (heart rate)                                                                                                                                                   | Inverse variance weighted | 8    | -0.00101 | 0.000812 | 0.215559 | 0.998683795 | -0.0026  | 0.000586 | 0.998994 | 0.997404998 | 1.000586374 |
| GCST001853-Circulating vasoactive peptide levels                                                                                                                                      | Inverse variance weighted | 4    | 0.004428 | 0.003584 | 0.2166   | 0.998683795 | -0.0026  | 0.011452 | 1.004438 | 0.997407534 | 1.011517364 |
| GCST000758-Triglycerides                                                                                                                                                              | Inverse variance weighted | 21   | 0.004448 | 0.003601 | 0.216785 | 0.998683795 | -0.00261 | 0.011506 | 1.004458 | 0.997393131 | 1.011572004 |
| GCST001005-HDL Cholesterol - Triglycerides (HDLC-TG)                                                                                                                                  | Inverse variance weighted | 6    | 0.307193 | 0.249144 | 0.217577 | 0.998683795 | -0.18113 | 0.795515 | 1.359604 | 0.834328459 | 2.215581309 |
| GCST000403-Menarche and menopause (age at onset)                                                                                                                                      | Inverse variance weighted | 4    | -0.02435 | 0.019818 | 0.219205 | 0.998683795 | -0.06319 | 0.014494 | 0.975944 | 0.938762    | 1.014599699 |
| GCST006022-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 4    | -0.08942 | 0.072895 | 0.219946 | 0.998683795 | -0.23229 | 0.053456 | 0.914463 | 0.792715058 | 1.054910246 |
| GCST006462-Uterine fibroids                                                                                                                                                           | Inverse variance weighted | 21   | -0.05694 | 0.046422 | 0.219972 | 0.998683795 | -0.14793 | 0.034046 | 0.944649 | 0.862492543 | 1.034632101 |
| GCST000392-Type 1 diabetes                                                                                                                                                            | Inverse variance weighted | 11   | 0.070951 | 0.057856 | 0.220075 | 0.998683795 | -0.04245 | 0.184349 | 1.073529 | 0.958440772 | 1.202435826 |
| GCST003454-Morning vs. evening chronotype                                                                                                                                             | Inverse variance weighted | 2    | -0.13408 | 0.109712 | 0.221649 | 0.998683795 | -0.34912 | 0.08095  | 0.874516 | 0.705308852 | 1.084316767 |
| GCST008165-Thyroid stimulating hormone levels                                                                                                                                         | Inverse variance weighted | 6    | -0.08843 | 0.07242  | 0.222046 | 0.998683795 | -0.23037 | 0.05351  | 0.915365 | 0.794235864 | 1.054967986 |
| GCST004235-Total cholesterol levels                                                                                                                                                   | Inverse variance weighted | 49   | 0.067722 | 0.055496 | 0.222348 | 0.998683795 | -0.04105 | 0.176494 | 1.070068 | 0.959781389 | 1.193026893 |
| GCST002525-Local histogram emphysema pattern                                                                                                                                          | Inverse variance weighted | 6    | 0.640969 | 0.525255 | 0.222351 | 0.998683795 | -0.38853 | 1.670468 | 1.898319 | 0.678052063 | 5.314657088 |
| GCST005325-Subjective well-being (MTAG)                                                                                                                                               | Inverse variance weighted | 36   | -0.28681 | 0.235166 | 0.22261  | 0.998683795 | -0.74774 | 0.174112 | 0.750653 | 0.473436835 | 1.190189363 |
| GCST000478-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 3    | 0.089035 | 0.073112 | 0.223305 | 0.998683795 | -0.05426 | 0.232334 | 1.093118 | 0.947181511 | 1.261540485 |
| GCST000438-Cutaneous nevi                                                                                                                                                             | Inverse variance weighted | 2    | -0.08727 | 0.071858 | 0.224579 | 0.998683795 | -0.22811 | 0.053575 | 0.916432 | 0.796036589 | 1.055035689 |
| GCST000803-Glycated hemoglobin levels                                                                                                                                                 | Inverse variance weighted | 8    | 0.190332 | 0.156735 | 0.224612 | 0.998683795 | -0.11687 | 0.497533 | 1.209651 | 0.889701903 | 1.644658611 |
| GCST000285-Cholesterol, total                                                                                                                                                         | Inverse variance weighted | 8    | 1.267259 | 1.045831 | 0.225618 | 0.998683795 | -0.78257 | 3.317087 | 3.551106 | 0.457229965 | 27.57989998 |
| GCST001725-Inflammatory bowel disease                                                                                                                                                 | Inverse variance weighted | 81   | -0.02888 | 0.023862 | 0.226226 | 0.998683795 | -0.07564 | 0.017893 | 0.971537 | 0.927145644 | 1.018053952 |
| GCST003075-Cognitive decline rate in late mild cognitive impairment                                                                                                                   | Inverse variance weighted | 8    | -0.06512 | 0.053837 | 0.226412 | 0.998683795 | -0.17064 | 0.040397 | 0.936951 | 0.843120875 | 1.041223554 |
| GCST001221-Permanent tooth development                                                                                                                                                | Inverse variance weighted | 2    | -0.14142 | 0.116912 | 0.226422 | 0.998683795 | -0.37057 | 0.087727 | 0.868125 | 0.69034305  | 1.09169028  |
| GCST007705-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 33   | -0.01126 | 0.009319 | 0.227002 | 0.998683795 | -0.02952 | 0.007007 | 0.988804 | 0.970907251 | 1.007031545 |
| GCST005367-Vitamin D levels                                                                                                                                                           | Inverse variance weighted | 2    | -0.73519 | 0.609391 | 0.227648 | 0.998683795 | -1.9296  | 0.459213 | 0.479412 | 0.145206133 | 1.582827791 |
| GCST004737-Neovascular age-related macular degeneration                                                                                                                               | Inverse variance weighted | 3    | -0.02017 | 0.016723 | 0.227836 | 0.998683795 | -0.05295 | 0.01261  | 0.980035 | 0.948432104 | 1.012690018 |
| GCST000408-Primary biliary cholangitis                                                                                                                                                | Inverse variance weighted | 2    | -0.03452 | 0.028661 | 0.228365 | 0.998683795 | -0.0907  | 0.021651 | 0.966065 | 0.913291543 | 1.021887133 |
| GCST000224-Chronic lymphocytic leukemia                                                                                                                                               | Inverse variance weighted | 4    | -0.04734 | 0.039431 | 0.229931 | 0.998683795 | -0.12462 | 0.029946 | 0.953765 | 0.882829605 | 1.030399248 |
| GCST004887-Alcohol consumption in current drinkers                                                                                                                                    | Inverse variance weighted | 4    | 0.594399 | 0.495418 | 0.23022  | 0.998683795 | -0.37662 | 1.565418 | 1.811941 | 0.686176679 | 4.784673006 |
| GCST004946-Schizophrenia                                                                                                                                                              | Inverse variance weighted | 72   | -0.04641 | 0.038712 | 0.230544 | 0.998683795 | -0.12229 | 0.029461 | 0.954647 | 0.884893137 | 1.029899469 |
| GCST007324-Adventurousness                                                                                                                                                            | Inverse variance weighted | 106  | -0.15085 | 0.125968 | 0.231097 | 0.998683795 | -0.39775 | 0.096046 | 0.859975 | 0.671830464 | 1.100809565 |
| GCST006719-BRCA1/2-negative high-risk breast cancer                                                                                                                                   | Inverse variance weighted | 2    | -0.06478 | 0.054101 | 0.231176 | 0.998683795 | -0.17081 | 0.041261 | 0.937277 | 0.842977647 | 1.042124025 |
| GCST007062-Hodgkin's lymphoma                                                                                                                                                         | Inverse variance weighted | 3    | 0.076721 | 0.06418  | 0.231935 | 0.998683795 | -0.04907 | 0.202514 | 1.07974  | 0.952111506 | 1.224477763 |
| GCST001708-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 3    | -0.03807 | 0.0319   | 0.232766 | 0.998683795 | -0.10059 | 0.024459 | 0.96265  | 0.904304332 | 1.024760463 |
| GCST005795-Femoral neck bone mineral density                                                                                                                                          | Inverse variance weighted | 15   | 0.13471  | 0.113253 | 0.23426  | 0.998683795 | -0.08727 | 0.356687 | 1.144205 | 0.916432778 | 1.428588315 |
| GCST003335-Waist circumference                                                                                                                                                        | Inverse variance weighted | 2    | -0.39652 | 0.333598 | 0.234587 | 0.998683795 | -1.05037 | 0.257329 | 0.672655 | 0.349806707 | 1.293470125 |
| GCST002626-Vertical cup-disc ratio                                                                                                                                                    | Inverse variance weighted | 9    | -0.85118 | 0.717088 | 0.235232 | 0.998683795 | -2.25667 | 0.554317 | 0.426913 | 0.104698647 | 1.740751294 |
| GCST004006-Mean corpuscular hemoglobin                                                                                                                                                | Inverse variance weighted | 7    | -2.17748 | 1.834837 | 0.235329 | 0.998683795 | -5.77376 | 1.418799 | 0.113327 | 0.003108042 | 4.132153094 |
| GCST003094-Mitral valve prolapse                                                                                                                                                      | Inverse variance weighted | 2    | -0.07147 | 0.060623 | 0.238425 | 0.998683795 | -0.19029 | 0.047351 | 0.931024 | 0.826718365 | 1.048489553 |
| GCST004462-Epithelial ovarian cancer                                                                                                                                                  | Inverse variance weighted | 7    | -0.07408 | 0.062877 | 0.238752 | 0.998683795 | -0.19732 | 0.049163 | 0.928601 | 0.820930989 | 1.050391585 |
| GCST004441-Interleukin-18 levels                                                                                                                                                      | Inverse variance weighted | 5    | 0.041467 | 0.035211 | 0.238926 | 0.998683795 | -0.02755 | 0.110481 | 1.042339 | 0.972829439 | 1.116815175 |
| GCST006702-Parental longevity (combined parental age at death)                                                                                                                        | Inverse variance weighted | 3    | -13.1268 | 11.15606 | 0.239333 | 0.998683795 | -34.9927 | 8.739026 | 1.99E-06 | 6.35116E-16 | 6241.810843 |
| GCST002906-Skin colour saturation                                                                                                                                                     | Inverse variance weighted | 3    | 1.694678 | 1.441325 | 0.239684 | 0.998683795 | -1.13032 | 4.519676 | 5.444895 | 0.322930221 | 91.80584497 |
| GCST006586-Urinary albumin excretion                                                                                                                                                  | Inverse variance weighted | 23   | 0.393966 | 0.335592 | 0.240418 | 0.998683795 | -0.26379 | 1.051725 | 1.48285  | 0.768131752 | 2.862585575 |
| GCST004139-Bipolar disorder                                                                                                                                                           | Inverse variance weighted | 4    | 0.077791 | 0.066493 | 0.242035 | 0.998683795 | -0.05253 | 0.208117 | 1.080897 | 0.948821175 | 1.231356692 |
| GCST005913-Fasting blood glucose                                                                                                                                                      | Inverse variance weighted | 3    | 0.123373 | 0.105674 | 0.243014 | 0.998683795 | -0.08375 | 0.330493 | 1.131306 | 0.919663214 | 1.391654421 |
| GCST000809-Triglycerides                                                                                                                                                              | Inverse variance weighted | 5    | -0.1805  | 0.155215 | 0.244862 | 0.998683795 | -0.48472 | 0.123719 | 0.83485  | 0.615866937 | 1.131697867 |
| GCST001650-C-reactive protein                                                                                                                                                         | Inverse variance weighted | 4    | -0.90562 | 0.780174 | 0.245728 | 0.998683795 | -2.43476 | 0.623525 | 0.404293 | 0.087619057 | 1.865491592 |
| GCST006926-Osteoarthritis (hip)                                                                                                                                                       | Inverse variance weighted | 11   | 0.058965 | 0.050895 | 0.246632 | 0.998683795 | -0.04079 | 0.158719 | 1.060738 | 0.960031964 | 1.172008658 |
| GCST000623-Ulcerative colitis                                                                                                                                                         | Inverse variance weighted | 2    | 0.177153 | 0.153115 | 0.247276 | 0.998683795 | -0.12295 | 0.477258 | 1.193813 | 0.884305372 | 1.611648972 |
| GCST000142-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 4    | 0.044138 | 0.03815  | 0.247285 | 0.998683795 | -0.03064 | 0.118912 | 1.045127 | 0.969828953 | 1.126270997 |
| GCST006091-Freckles                                                                                                                                                                   | Inverse variance weighted | 6    | 0.047066 | 0.040817 | 0.248869 | 0.998683795 | -0.03294 | 0.127068 | 1.048191 | 0.967601243 | 1.135493804 |
| GCST004337-Gondoic acid (20:1n-9) levels                                                                                                                                              | Inverse variance weighted | 2    | -2.57185 | 2.236868 | 0.250246 | 0.998683795 | -6.95611 | 1.812415 | 0.076394 | 0.000952798 | 6.125224757 |
| GCST005847-Heart rate response to recovery post exercise (20 sec)                                                                                                                     | Inverse variance weighted | 10   | -0.13835 | 0.120418 | 0.250595 | 0.998683795 | -0.37437 | 0.09767  | 0.870795 | 0.687724686 | 1.102598914 |
| GCST004142-Melanoma                                                                                                                                                                   | Inverse variance weighted | 3    | -0.07265 | 0.063266 | 0.250815 | 0.998683795 | -0.19665 | 0.051348 | 0.929924 | 0.82147527  | 1.052689397 |
| GCST001237-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 4    | 0.523867 | 0.457915 | 0.252612 | 0.998683795 | -0.37365 | 1.421381 | 1.688545 | 0.688220725 | 4.142835944 |
| GCST003218-Non-cardia gastric cancer                                                                                                                                                  | Inverse variance weighted | 2    | -0.09265 | 0.081013 | 0.25278  | 0.998683795 | -0.25143 | 0.066137 | 0.911514 | 0.777685801 | 1.06837282  |
| GCST007485-Anthropometric traits                                                                                                                                                      | Inverse variance weighted | 5    | -0.26338 | 0.231835 | 0.255933 | 0.998683795 | -0.71778 | 0.19102  | 0.768451 | 0.487836209 | 1.210483093 |
| GCST000970-Optic disc area                                                                                                                                                            | Inverse variance weighted | 4    | -0.19087 | 0.168237 | 0.256565 | 0.998683795 | -0.52062 | 0.138871 | 0.826238 | 0.594154273 | 1.148976391 |
| GCST002326-Pulmonary emphysema                                                                                                                                                        | Inverse variance weighted | 2    | -0.07708 | 0.068004 | 0.257025 | 0.998683795 | -0.21037 | 0.056209 | 0.925817 | 0.810286761 | 1.057818484 |
| GCST000298-Body mass index                                                                                                                                                            | Inverse variance weighted | 4    | -0.13416 | 0.118427 | 0.257275 | 0.998683795 | -0.36628 | 0.097956 | 0.874449 | 0.693310172 | 1.102914469 |
| GCST002560-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 2    | -0.13064 | 0.115769 | 0.259131 | 0.998683795 | -0.35755 | 0.096268 | 0.877534 | 0.699389491 | 1.101054306 |
| GCST003391-Low high density lipoprotein cholesterol levels                                                                                                                            | Inverse variance weighted | 5    | 0.035371 | 0.031373 | 0.259566 | 0.998683795 | -0.02612 | 0.096863 | 1.036004 | 0.9742172   | 1.10170934  |
| GCST002669-Percent mammographic density                                                                                                                                               | Inverse variance weighted | 2    | 0.128355 | 0.113917 | 0.259851 | 0.998683795 | -0.09492 | 0.351632 | 1.136957 | 0.909444056 | 1.421385343 |
| GCST004438-Monocyte chemoattractant protein-1 levels                                                                                                                                  | Inverse variance weighted | 6    | 0.062475 | 0.055545 | 0.260688 | 0.998683795 | -0.04639 | 0.171342 | 1.064468 | 0.954666937 | 1.186897118 |
| GCST001178-Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid)                                                                                                    | Inverse variance weighted | 8    | 0.112165 | 0.099733 | 0.260734 | 0.998683795 | -0.08331 | 0.307641 | 1.118697 | 0.920065062 | 1.360212428 |
| GCST006980-Fractures                                                                                                                                                                  | Inverse variance weighted | 8    | -0.15582 | 0.138767 | 0.261473 | 0.998683795 | -0.42781 | 0.116159 | 0.85571  | 0.651938029 | 1.123174693 |
| GCST002759-Motion sickness                                                                                                                                                            | Inverse variance weighted | 24   | -0.09621 | 0.085765 | 0.261953 | 0.998683795 | -0.26431 | 0.07189  | 0.908273 | 0.76773517  | 1.074536687 |
| GCST000759-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 24   | 0.002466 | 0.0022   | 0.262433 | 0.998683795 | -0.00185 | 0.006778 | 1.002469 | 0.998154982 | 1.006801101 |
| GCST000180-Bone mineral density (spine)                                                                                                                                               | Inverse variance weighted | 5    | -0.06953 | 0.062167 | 0.263384 | 0.998683795 | -0.19138 | 0.052318 | 0.932833 | 0.825821217 | 1.053710739 |
| GCST006874-Hippocampal subfield CA1 volume (corrected for total hippocampal volume)                                                                                                   | Inverse variance weighted | 2    | -0.00879 | 0.007866 | 0.264067 | 0.998683795 | -0.0242  | 0.006633 | 0.991253 | 0.976086703 | 1.006654825 |
| GCST002731-Endothelial growth factor levels                                                                                                                                           | Inverse variance weighted | 3    | 0.1153   | 0.1033   | 0.264351 | 0.998683795 | -0.08717 | 0.317767 | 1.12221  | 0.916523469 | 1.374055795 |
| GCST007097-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 32   | 0.013212 | 0.011855 | 0.265083 | 0.998683795 | -0.01002 | 0.036448 | 1.0133   | 0.990026185 | 1.03711998  |
| GCST004433-Macrophage inflammatory protein 1b levels                                                                                                                                  | Inverse variance weighted | 25   | 0.024272 | 0.021791 | 0.265355 | 0.998683795 | -0.01844 | 0.066983 | 1.024569 | 0.981729573 | 1.069277287 |
| GCST002443-Blood metabolite levels                                                                                                                                                    | Inverse variance weighted | 120  | -0.03722 | 0.033476 | 0.266195 | 0.998683795 | -0.10284 | 0.028392 | 0.963463 | 0.902275812 | 1.028799283 |
| GCST008057-Varicose veins                                                                                                                                                             | Inverse variance weighted | 6    | 2.118687 | 1.910744 | 0.267504 | 0.998683795 | -1.62637 | 5.863746 | 8.320208 | 0.196641898 | 352.0402699 |
| GCST007924-Medication use (antithrombotic agents)                                                                                                                                     | Inverse variance weighted | 7    | 0.488193 | 0.440911 | 0.268191 | 0.998683795 | -0.37599 | 1.352378 | 1.629369 | 0.686607821 | 3.866609901 |
| GCST006705-Infantile hypertrophic pyloric stenosis                                                                                                                                    | Inverse variance weighted | 2    | -0.07333 | 0.066264 | 0.268463 | 0.998683795 | -0.20321 | 0.056549 | 0.929296 | 0.816110318 | 1.05817862  |
| GCST004127-White blood cell count (basophil)                                                                                                                                          | Inverse variance weighted | 3    | -0.37936 | 0.343048 | 0.268788 | 0.998683795 | -1.05174 | 0.293012 | 0.684297 | 0.34933041  | 1.340458821 |
| GCST000380-Height                                                                                                                                                                     | Inverse variance weighted | 3    | -0.03356 | 0.030426 | 0.27008  | 0.998683795 | -0.09319 | 0.026079 | 0.967    | 0.911018679 | 1.026421988 |
| GCST001233-Metabolite levels                                                                                                                                                          | Inverse variance weighted | 7    | 0.253442 | 0.229969 | 0.270431 | 0.998683795 | -0.1973  | 0.704181 | 1.288453 | 0.820946782 | 2.022189913 |
| GCST003845-Breast cancer                                                                                                                                                              | Inverse variance weighted | 10   | -0.08059 | 0.073185 | 0.270797 | 0.998683795 | -0.22404 | 0.062849 | 0.922569 | 0.799285919 | 1.064866418 |
| GCST003799-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 19   | 0.039017 | 0.035443 | 0.270967 | 0.998683795 | -0.03045 | 0.108486 | 1.039788 | 0.970007522 | 1.114589144 |
| GCST007001-Cerebrospinal AB1-42 levels in normal cognition                                                                                                                            | Inverse variance weighted | 3    | -0.59301 | 0.53873  | 0.271003 | 0.998683795 | -1.64892 | 0.462901 | 0.552661 | 0.192257394 | 1.588675957 |
| GCST004339-Palmitoleic acid (16:1n-7) levels                                                                                                                                          | Inverse variance weighted | 4    | 0.465398 | 0.423278 | 0.271545 | 0.998683795 | -0.36423 | 1.295022 | 1.592648 | 0.694734256 | 3.651076648 |
| GCST006062-White matter hyperintensity volume                                                                                                                                         | Inverse variance weighted | 2    | -0.13872 | 0.126573 | 0.273086 | 0.998683795 | -0.38681 | 0.109361 | 0.87047  | 0.679223475 | 1.11556522  |
| GCST007305-White matter hyperintensity volume                                                                                                                                         | Inverse variance weighted | 2    | -0.14539 | 0.132716 | 0.273313 | 0.998683795 | -0.40551 | 0.114737 | 0.864689 | 0.66663765  | 1.121578949 |
| GCST000452-QT interval                                                                                                                                                                | Inverse variance weighted | 2    | -0.0696  | 0.063759 | 0.274969 | 0.998683795 | -0.19457 | 0.055362 | 0.932763 | 0.823187396 | 1.056923363 |
| GCST000879-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 52   | -0.01928 | 0.017662 | 0.27503  | 0.998683795 | -0.0539  | 0.015338 | 0.980906 | 0.947530307 | 1.015456729 |
| GCST004483-Multiple myeloma                                                                                                                                                           | Inverse variance weighted | 5    | -0.08341 | 0.076594 | 0.276156 | 0.998683795 | -0.23353 | 0.066714 | 0.919973 | 0.791730111 | 1.068989377 |
| GCST004626-Myeloid white cell count                                                                                                                                                   | Inverse variance weighted | 69   | -0.08252 | 0.075798 | 0.276313 | 0.998683795 | -0.23108 | 0.066047 | 0.920796 | 0.793675438 | 1.068277226 |
| GCST007536-Serum urea levels                                                                                                                                                          | Inverse variance weighted | 3    | -0.13877 | 0.12753  | 0.276524 | 0.998683795 | -0.38873 | 0.111186 | 0.870425 | 0.677914964 | 1.117602683 |
| GCST001089-Esophageal cancer                                                                                                                                                          | Inverse variance weighted | 3    | 0.04086  | 0.037645 | 0.277743 | 0.998683795 | -0.03292 | 0.114645 | 1.041707 | 0.967611596 | 1.121475767 |
| GCST005046-N-glycan levels                                                                                                                                                            | Inverse variance weighted | 11   | 0.024093 | 0.022216 | 0.278155 | 0.998683795 | -0.01945 | 0.067637 | 1.024386 | 0.980736956 | 1.069976792 |
| GCST000282-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 7    | 0.538684 | 0.496835 | 0.278262 | 0.998683795 | -0.43511 | 1.51248  | 1.71375  | 0.647191764 | 4.537972399 |
| GCST006941-Irritable mood                                                                                                                                                             | Inverse variance weighted | 45   | 0.000568 | 0.000524 | 0.278517 | 0.998683795 | -0.00046 | 0.001595 | 1.000568 | 0.999540855 | 1.001596308 |
| GCST007798-Asthma                                                                                                                                                                     | Inverse variance weighted | 60   | -0.0476  | 0.044006 | 0.279448 | 0.998683795 | -0.13385 | 0.038657 | 0.95352  | 0.874723263 | 1.039413814 |
| GCST007325-General risk tolerance (MTAG)                                                                                                                                              | Inverse variance weighted | 185  | -0.17883 | 0.165537 | 0.280016 | 0.998683795 | -0.50328 | 0.145625 | 0.836251 | 0.604545703 | 1.15676244  |
| GCST007937-Medication use (salicylic acid and derivatives)                                                                                                                            | Inverse variance weighted | 5    | 0.652764 | 0.605034 | 0.280638 | 0.998683795 | -0.5331  | 1.838631 | 1.920842 | 0.586780819 | 6.287924684 |
| GCST006465-Endometrial cancer (endometrioid histology)                                                                                                                                | Inverse variance weighted | 8    | 0.058053 | 0.053909 | 0.281545 | 0.998683795 | -0.04761 | 0.163715 | 1.059771 | 0.953505851 | 1.177878341 |
| GCST007993-Asthma (adult onset)                                                                                                                                                       | Inverse variance weighted | 9    | -0.07842 | 0.07293  | 0.282265 | 0.998683795 | -0.22136 | 0.064525 | 0.924579 | 0.801428351 | 1.066652311 |
| GCST002562-Vogt-Koyanagi-Harada syndrome                                                                                                                                              | Inverse variance weighted | 2    | 0.045918 | 0.042944 | 0.284953 | 0.998683795 | -0.03825 | 0.130089 | 1.046989 | 0.962470297 | 1.138929448 |
| GCST002873-Thyroid cancer                                                                                                                                                             | Inverse variance weighted | 2    | 0.027792 | 0.026039 | 0.285822 | 0.998683795 | -0.02324 | 0.078827 | 1.028182 | 0.97702423  | 1.082017526 |
| GCST002082-Cervical cancer                                                                                                                                                            | Inverse variance weighted | 2    | 0.061692 | 0.057921 | 0.286831 | 0.998683795 | -0.05183 | 0.175218 | 1.063635 | 0.949486674 | 1.191505354 |
| GCST004617-Eosinophil percentage of granulocytes                                                                                                                                      | Inverse variance weighted | 94   | -0.05935 | 0.05573  | 0.286897 | 0.998683795 | -0.16858 | 0.049881 | 0.942377 | 0.844863397 | 1.051145921 |
| GCST001841-Palmitoleic acid (16:1n-7) levels                                                                                                                                          | Inverse variance weighted | 5    | 0.425596 | 0.400457 | 0.287883 | 0.998683795 | -0.3593  | 1.210492 | 1.530503 | 0.6981655   | 3.355133809 |
| GCST000168-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 2    | 0.085036 | 0.080206 | 0.289044 | 0.998683795 | -0.07217 | 0.24224  | 1.088757 | 0.930374835 | 1.274100397 |
| GCST007091-Osteoarthritis (hip)                                                                                                                                                       | Inverse variance weighted | 15   | 0.071437 | 0.067611 | 0.290704 | 0.998683795 | -0.06108 | 0.203955 | 1.07405  | 0.940746483 | 1.226243282 |
| GCST003372-Glomerular filtration rate (creatinine)                                                                                                                                    | Inverse variance weighted | 25   | 0.459816 | 0.436026 | 0.291626 | 0.998683795 | -0.3948  | 1.314428 | 1.583783 | 0.673817779 | 3.722622148 |
| GCST007095-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 26   | -0.01039 | 0.009857 | 0.291876 | 0.998683795 | -0.02971 | 0.008931 | 0.989664 | 0.970726936 | 1.008970563 |
| GCST007329-Automobile speeding propensity                                                                                                                                             | Inverse variance weighted | 20   | -0.27238 | 0.258468 | 0.291955 | 0.998683795 | -0.77898 | 0.234213 | 0.761561 | 0.45887263  | 1.263913319 |
| GCST001335-Mean platelet volume                                                                                                                                                       | Inverse variance weighted | 17   | 0.377203 | 0.358412 | 0.292603 | 0.998683795 | -0.32529 | 1.079691 | 1.4582   | 0.722321402 | 2.943770732 |
| GCST004041-Response to paliperidone in schizophrenia (negative Marder score)                                                                                                          | Inverse variance weighted | 2    | 0.013351 | 0.012693 | 0.292874 | 0.998683795 | -0.01153 | 0.038228 | 1.01344  | 0.988539121 | 1.03896859  |
| GCST001292-Leprosy                                                                                                                                                                    | Inverse variance weighted | 3    | -0.04369 | 0.041581 | 0.293378 | 0.998683795 | -0.12519 | 0.037808 | 0.95725  | 0.882330887 | 1.038531329 |
| GCST000305-Mean platelet volume                                                                                                                                                       | Inverse variance weighted | 2    | 0.630609 | 0.603058 | 0.295706 | 0.998683795 | -0.55139 | 1.812603 | 1.878754 | 0.57615125  | 6.126372257 |
| GCST000699-Optic disc parameters                                                                                                                                                      | Inverse variance weighted | 2    | -0.39898 | 0.381755 | 0.295972 | 0.998683795 | -1.14721 | 0.349264 | 0.671007 | 0.317519912 | 1.418022964 |
| GCST006629-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 71   | 0.02543  | 0.02437  | 0.296728 | 0.998683795 | -0.02234 | 0.073196 | 1.025756 | 0.977911616 | 1.075940982 |
| GCST004460-Eotaxin levels                                                                                                                                                             | Inverse variance weighted | 7    | 0.05598  | 0.053749 | 0.297644 | 0.998683795 | -0.04937 | 0.161328 | 1.057576 | 0.951830087 | 1.175070541 |
| GCST004621-Red cell distribution width                                                                                                                                                | Inverse variance weighted | 98   | -0.23001 | 0.221108 | 0.298219 | 0.998683795 | -0.66338 | 0.203362 | 0.794526 | 0.515106331 | 1.225516019 |
| GCST004633-Neutrophil percentage of white cells                                                                                                                                       | Inverse variance weighted | 61   | 0.094332 | 0.090748 | 0.298573 | 0.998683795 | -0.08353 | 0.272199 | 1.098925 | 0.919859896 | 1.312848027 |
| GCST000324-Carotenoid and tocopherol levels                                                                                                                                           | Inverse variance weighted | 2    | 0.107465 | 0.103448 | 0.298881 | 0.998683795 | -0.09529 | 0.310222 | 1.113452 | 0.909107209 | 1.363728448 |
| GCST006585-Blood protein levels                                                                                                                                                       | Inverse variance weighted | 536  | -0.00228 | 0.002203 | 0.300695 | 0.998683795 | -0.0066  | 0.002038 | 0.997723 | 0.993423946 | 1.002039949 |
| GCST004628-Immature fraction of reticulocytes                                                                                                                                         | Inverse variance weighted | 68   | 0.088705 | 0.085949 | 0.302044 | 0.998683795 | -0.07976 | 0.257166 | 1.092758 | 0.923341685 | 1.29325993  |
| GCST000996-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 3    | 0.033726 | 0.032715 | 0.302583 | 0.998683795 | -0.03039 | 0.097846 | 1.034301 | 0.970062438 | 1.102793436 |
| GCST004202-Systemic sclerosis                                                                                                                                                         | Inverse variance weighted | 3    | 0.060751 | 0.058936 | 0.302638 | 0.998683795 | -0.05476 | 0.176265 | 1.062634 | 0.946708858 | 1.192754114 |
| GCST001941-Ovarian cancer                                                                                                                                                             | Inverse variance weighted | 5    | -0.06995 | 0.067888 | 0.302813 | 0.998683795 | -0.20301 | 0.063108 | 0.932437 | 0.816266652 | 1.065141413 |
| GCST002252-Blood pressure measurement (high sodium and potassium intervention)                                                                                                        | Inverse variance weighted | 3    | 0.004135 | 0.004016 | 0.303218 | 0.998683795 | -0.00374 | 0.012006 | 1.004143 | 0.996270195 | 1.012078821 |
| GCST005326-Neuroticism (MTAG)                                                                                                                                                         | Inverse variance weighted | 27   | 0.247643 | 0.240615 | 0.303382 | 0.998683795 | -0.22396 | 0.719249 | 1.281003 | 0.79934479  | 2.052891025 |
| GCST002875-Diisocyanate-induced asthma                                                                                                                                                | Inverse variance weighted | 5    | -0.01005 | 0.009768 | 0.303659 | 0.998683795 | -0.02919 | 0.009097 | 0.990003 | 0.971230418 | 1.009138848 |
| GCST002299-Chronic lymphocytic leukemia                                                                                                                                               | Inverse variance weighted | 2    | -0.05594 | 0.054403 | 0.303873 | 0.998683795 | -0.16257 | 0.050695 | 0.9456   | 0.849959883 | 1.052002023 |
| GCST006041-Major depressive disorder                                                                                                                                                  | Inverse variance weighted | 10   | -0.18077 | 0.176262 | 0.305102 | 0.998683795 | -0.52624 | 0.164708 | 0.83463  | 0.590822131 | 1.17904854  |
| GCST000913-Iron status biomarkers                                                                                                                                                     | Inverse variance weighted | 2    | -0.32958 | 0.32155  | 0.305383 | 0.998683795 | -0.95981 | 0.300663 | 0.719229 | 0.382964347 | 1.350754258 |
| GCST001134-White blood cell types                                                                                                                                                     | Inverse variance weighted | 6    | -0.20574 | 0.200742 | 0.305416 | 0.998683795 | -0.59919 | 0.187716 | 0.814046 | 0.549255156 | 1.206490899 |
| GCST005324-Depressive symptoms                                                                                                                                                        | Inverse variance weighted | 25   | -0.25846 | 0.252208 | 0.305457 | 0.998683795 | -0.75279 | 0.235865 | 0.772237 | 0.471049496 | 1.266003415 |
| GCST008167-Mean platelet volume                                                                                                                                                       | Inverse variance weighted | 2    | 0.082056 | 0.080082 | 0.305526 | 0.998683795 | -0.0749  | 0.239016 | 1.085517 | 0.927832621 | 1.26999888  |
| GCST003559-Bone mineral density (hip)                                                                                                                                                 | Inverse variance weighted | 2    | -0.11647 | 0.113785 | 0.306015 | 0.998683795 | -0.33949 | 0.106546 | 0.890055 | 0.7121327   | 1.112428928 |
| GCST000138-Triglycerides                                                                                                                                                              | Inverse variance weighted | 6    | -0.07454 | 0.073015 | 0.307284 | 0.998683795 | -0.21765 | 0.068565 | 0.928167 | 0.804405043 | 1.070970674 |
| GCST003227-Non-glioblastoma glioma                                                                                                                                                    | Inverse variance weighted | 4    | -0.05237 | 0.051314 | 0.307476 | 0.998683795 | -0.15294 | 0.048208 | 0.94898  | 0.85817863  | 1.04938871  |
| GCST005414-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 3    | -0.18966 | 0.186114 | 0.308184 | 0.998683795 | -0.55444 | 0.175126 | 0.827242 | 0.574393416 | 1.191395992 |
| GCST002500-QT interval                                                                                                                                                                | Inverse variance weighted | 42   | -0.00317 | 0.003114 | 0.309294 | 0.998683795 | -0.00927 | 0.002938 | 0.996839 | 0.990772908 | 1.002941889 |
| GCST001804-Behcet's disease                                                                                                                                                           | Inverse variance weighted | 3    | -0.0421  | 0.04152  | 0.310584 | 0.998683795 | -0.12348 | 0.039278 | 0.958773 | 0.883839006 | 1.040059652 |
| GCST006950-Feeling worry                                                                                                                                                              | Inverse variance weighted | 44   | 0.000624 | 0.000615 | 0.310984 | 0.998683795 | -0.00058 | 0.00183  | 1.000624 | 0.999417412 | 1.001831585 |
| GCST000843-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 5    | -0.11644 | 0.114928 | 0.310994 | 0.998683795 | -0.3417  | 0.108821 | 0.890085 | 0.710563648 | 1.114962669 |
| GCST005345-Total body bone mineral density (age 0-15)                                                                                                                                 | Inverse variance weighted | 6    | -0.08445 | 0.083427 | 0.311401 | 0.998683795 | -0.24797 | 0.079065 | 0.919016 | 0.780384372 | 1.082274361 |
| GCST004612-High light scatter reticulocyte percentage of red cells                                                                                                                    | Inverse variance weighted | 85   | 0.067494 | 0.066678 | 0.311426 | 0.998683795 | -0.06319 | 0.198182 | 1.069823 | 0.938760465 | 1.219184583 |
| GCST001728-Ulcerative colitis                                                                                                                                                         | Inverse variance weighted | 18   | 0.042979 | 0.04247  | 0.311541 | 0.998683795 | -0.04026 | 0.126221 | 1.043916 | 0.960537919 | 1.13453259  |
| GCST000371-Tanning                                                                                                                                                                    | Inverse variance weighted | 5    | -0.05146 | 0.050894 | 0.311915 | 0.998683795 | -0.15122 | 0.048288 | 0.949837 | 0.859660499 | 1.049472784 |
| GCST004424-TRAIL levels                                                                                                                                                               | Inverse variance weighted | 6    | 0.05529  | 0.054824 | 0.313216 | 0.998683795 | -0.05217 | 0.162745 | 1.056847 | 0.94917182  | 1.176737114 |
| GCST008062-Blood urea nitrogen levels                                                                                                                                                 | Inverse variance weighted | 70   | -0.37931 | 0.376491 | 0.313701 | 0.998683795 | -1.11723 | 0.358612 | 0.684334 | 0.327184401 | 1.431341936 |
| GCST008085-HDL cholesterol levels in current drinkers                                                                                                                                 | Inverse variance weighted | 34   | -0.30808 | 0.306356 | 0.314595 | 0.998683795 | -0.90854 | 0.292378 | 0.734856 | 0.403113096 | 1.33960919  |
| GCST005863-Menopause (age at onset)                                                                                                                                                   | Inverse variance weighted | 10   | -0.04547 | 0.045245 | 0.314912 | 0.998683795 | -0.13415 | 0.04321  | 0.955549 | 0.874459962 | 1.04415716  |
| GCST004858-Dupuytren's disease                                                                                                                                                        | Inverse variance weighted | 20   | 0.01961  | 0.019516 | 0.31499  | 0.998683795 | -0.01864 | 0.05786  | 1.019803 | 0.981531318 | 1.059567153 |
| GCST007142-Triglycerides                                                                                                                                                              | Inverse variance weighted | 139  | 0.195768 | 0.194962 | 0.315315 | 0.998683795 | -0.18636 | 0.577893 | 1.216244 | 0.829976284 | 1.782280016 |
| GCST000585-Mean corpuscular volume                                                                                                                                                    | Inverse variance weighted | 11   | 0.098294 | 0.097944 | 0.315582 | 0.998683795 | -0.09368 | 0.290265 | 1.103288 | 0.910577809 | 1.33678153  |
| GCST003879-Serum parathyroid hormone levels                                                                                                                                           | Inverse variance weighted | 4    | 0.005672 | 0.005658 | 0.316099 | 0.998683795 | -0.00542 | 0.016763 | 1.005689 | 0.994596931 | 1.016903825 |
| GCST004600-Eosinophil percentage of white cells                                                                                                                                       | Inverse variance weighted | 87   | -0.05261 | 0.052794 | 0.318965 | 0.998683795 | -0.15609 | 0.050862 | 0.948746 | 0.855482195 | 1.052178075 |
| GCST005790-Rosacea symptom severity                                                                                                                                                   | Inverse variance weighted | 6    | -0.05601 | 0.056248 | 0.319376 | 0.998683795 | -0.16626 | 0.054238 | 0.945531 | 0.84682978  | 1.055735757 |
| GCST001912-Acute lymphoblastic leukemia (childhood)                                                                                                                                   | Inverse variance weighted | 3    | -0.02394 | 0.024103 | 0.320601 | 0.998683795 | -0.07118 | 0.023302 | 0.976345 | 0.931293255 | 1.023575693 |
| GCST003635-middle facial morphology traits (quantitative measurement)                                                                                                                 | Inverse variance weighted | 4    | -0.19231 | 0.193897 | 0.321284 | 0.998683795 | -0.57235 | 0.187727 | 0.82505  | 0.56419779  | 1.206503859 |
| GCST000692-Vitiligo                                                                                                                                                                   | Inverse variance weighted | 2    | -0.05898 | 0.059992 | 0.325506 | 0.998683795 | -0.17657 | 0.058599 | 0.942722 | 0.838141832 | 1.060350446 |
| GCST002147-Fibrinogen                                                                                                                                                                 | Inverse variance weighted | 12   | 0.487797 | 0.497855 | 0.327186 | 0.998683795 | -0.488   | 1.463592 | 1.628724 | 0.613854221 | 4.321455092 |
| GCST004007-Mean corpuscular hemoglobin concentration                                                                                                                                  | Inverse variance weighted | 3    | -5.09695 | 5.211364 | 0.328052 | 0.998683795 | -15.3112 | 5.117325 | 0.006115 | 2.24089E-07 | 166.8882792 |
| GCST006436-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 9    | -0.00171 | 0.001748 | 0.329336 | 0.998683795 | -0.00513 | 0.001721 | 0.998296 | 0.994880737 | 1.001722887 |
| GCST004560-Body mass index in physically inactive individuals                                                                                                                         | Inverse variance weighted | 10   | -0.08651 | 0.088889 | 0.330445 | 0.998683795 | -0.26073 | 0.087714 | 0.917128 | 0.770488681 | 1.091675809 |
| GCST000842-Bladder cancer                                                                                                                                                             | Inverse variance weighted | 4    | 0.092451 | 0.095001 | 0.330478 | 0.998683795 | -0.09375 | 0.278653 | 1.096859 | 0.910508674 | 1.321349108 |
| GCST005075-Breast Cancer in BRCA1 mutation carriers                                                                                                                                   | Inverse variance weighted | 2    | -0.09348 | 0.096518 | 0.332791 | 0.998683795 | -0.28265 | 0.095697 | 0.910758 | 0.753781592 | 1.100425051 |
| GCST002582-Glaucoma (primary open-angle)                                                                                                                                              | Inverse variance weighted | 2    | -0.05082 | 0.052484 | 0.33294  | 0.998683795 | -0.15368 | 0.052053 | 0.950454 | 0.857543262 | 1.053431622 |
| GCST006481-Lung function (FEV1)                                                                                                                                                       | Inverse variance weighted | 10   | 0.000296 | 0.000306 | 0.332999 | 0.998683795 | -0.0003  | 0.000895 | 1.000296 | 0.999696836 | 1.000895467 |
| GCST000440-Glioma (high-grade)                                                                                                                                                        | Inverse variance weighted | 2    | -0.06647 | 0.068717 | 0.333392 | 0.998683795 | -0.20116 | 0.068215 | 0.935691 | 0.817785478 | 1.07059534  |
| GCST006949-Suffering from nerves                                                                                                                                                      | Inverse variance weighted | 7    | 0.002444 | 0.002529 | 0.333827 | 0.998683795 | -0.00251 | 0.007401 | 1.002447 | 0.997490566 | 1.007427993 |
| GCST001856-Thyroid hormone levels                                                                                                                                                     | Inverse variance weighted | 16   | -0.05336 | 0.055272 | 0.334311 | 0.998683795 | -0.1617  | 0.05497  | 0.948035 | 0.850698334 | 1.056509233 |
| GCST001482-Lumbar spine bone mineral density                                                                                                                                          | Inverse variance weighted | 16   | 0.077251 | 0.080249 | 0.335731 | 0.998683795 | -0.08004 | 0.23454  | 1.080313 | 0.923081301 | 1.26432687  |
| GCST001587-Coronary heart disease                                                                                                                                                     | Inverse variance weighted | 3    | 0.041909 | 0.043611 | 0.336562 | 0.998683795 | -0.04357 | 0.127387 | 1.0428   | 0.95736718  | 1.135856462 |
| GCST001179-Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid)                                                                                                   | Inverse variance weighted | 11   | 0.099558 | 0.103716 | 0.3371   | 0.998683795 | -0.10373 | 0.302841 | 1.104682 | 0.901473025 | 1.353699246 |
| GCST004011-RR interval (tricyclic/tetracyclic antidepressant use interaction)                                                                                                         | Inverse variance weighted | 2    | -0.00041 | 0.000433 | 0.338107 | 0.998683795 | -0.00126 | 0.000434 | 0.999585 | 0.99873779  | 1.000433844 |
| GCST002115-Axial length                                                                                                                                                               | Inverse variance weighted | 4    | -0.11522 | 0.120871 | 0.340463 | 0.998683795 | -0.35213 | 0.121687 | 0.89117  | 0.703189868 | 1.129400751 |
| GCST004775-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 15   | -0.01322 | 0.013895 | 0.341476 | 0.998683795 | -0.04045 | 0.014017 | 0.986869 | 0.960355243 | 1.014115273 |
| GCST001086-Paget's disease                                                                                                                                                            | Inverse variance weighted | 6    | 0.016192 | 0.017038 | 0.341942 | 0.998683795 | -0.0172  | 0.049587 | 1.016324 | 0.982944257 | 1.050836926 |
| GCST004498-BMI in smokers                                                                                                                                                             | Inverse variance weighted | 9    | -0.1244  | 0.131049 | 0.34247  | 0.998683795 | -0.38126 | 0.132452 | 0.883023 | 0.682999616 | 1.141623987 |
| GCST001812-Epstein-Barr virus immune response (EBNA-1)                                                                                                                                | Inverse variance weighted | 2    | -0.13664 | 0.144045 | 0.342832 | 0.998683795 | -0.41897 | 0.145689 | 0.872286 | 0.657726644 | 1.156836307 |
| GCST005346-Total body bone mineral density (age 30-45)                                                                                                                                | Inverse variance weighted | 6    | 0.056935 | 0.060091 | 0.343395 | 0.998683795 | -0.06084 | 0.174715 | 1.058587 | 0.940970185 | 1.190906268 |
| GCST006464-Endometrial cancer                                                                                                                                                         | Inverse variance weighted | 10   | 0.046069 | 0.049032 | 0.347434 | 0.998683795 | -0.05003 | 0.142171 | 1.047147 | 0.951197981 | 1.152774291 |
| GCST001438-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 10   | -0.01816 | 0.019335 | 0.347591 | 0.998683795 | -0.05606 | 0.019736 | 0.982003 | 0.945484391 | 1.019931998 |
| GCST005196-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 97   | -0.04567 | 0.048688 | 0.348266 | 0.998683795 | -0.1411  | 0.049762 | 0.955359 | 0.868405123 | 1.051020464 |
| GCST000998-Coronary heart disease                                                                                                                                                     | Inverse variance weighted | 14   | -0.04943 | 0.052723 | 0.34846  | 0.998683795 | -0.15277 | 0.053905 | 0.95177  | 0.858328596 | 1.055384103 |
| GCST006021-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 14   | -0.02194 | 0.02347  | 0.349782 | 0.998683795 | -0.06795 | 0.024057 | 0.978294 | 0.934310289 | 1.024348447 |
| GCST000258-Type 1 diabetes                                                                                                                                                            | Inverse variance weighted | 3    | -0.07826 | 0.083815 | 0.350429 | 0.998683795 | -0.24254 | 0.086015 | 0.924721 | 0.784632091 | 1.08982223  |
| GCST001351-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 5    | 0.080917 | 0.086735 | 0.35086  | 0.998683795 | -0.08908 | 0.250919 | 1.084281 | 0.914768682 | 1.285205792 |
| GCST003116-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 24   | -0.03961 | 0.042533 | 0.351748 | 0.998683795 | -0.12297 | 0.043758 | 0.961167 | 0.884289438 | 1.044729004 |
| GCST001218-Lp (a) levels                                                                                                                                                              | Inverse variance weighted | 2    | -0.02498 | 0.026841 | 0.352112 | 0.998683795 | -0.07758 | 0.027633 | 0.975334 | 0.925348656 | 1.028018402 |
| GCST001727-Lipoprotein-associated phospholipase A2 activity and mass                                                                                                                  | Inverse variance weighted | 5    | -0.78307 | 0.843081 | 0.352983 | 0.998683795 | -2.43551 | 0.869369 | 0.457001 | 0.087553121 | 2.385404759 |
| GCST001729-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 23   | -0.03441 | 0.037056 | 0.353136 | 0.998683795 | -0.10704 | 0.038222 | 0.966178 | 0.898493551 | 1.038961747 |
| GCST005789-Resting heart rate                                                                                                                                                         | Inverse variance weighted | 10   | 0.008758 | 0.009455 | 0.354306 | 0.998683795 | -0.00977 | 0.027289 | 1.008796 | 0.990273993 | 1.027664565 |
| GCST001003-Metabolic syndrome                                                                                                                                                         | Inverse variance weighted | 4    | 0.055015 | 0.059444 | 0.354711 | 0.998683795 | -0.0615  | 0.171525 | 1.056556 | 0.940357391 | 1.187113665 |
| GCST002700-Cervical artery dissection                                                                                                                                                 | Inverse variance weighted | 2    | 0.045008 | 0.048656 | 0.354951 | 0.998683795 | -0.05036 | 0.140374 | 1.046036 | 0.95088933  | 1.150704198 |
| GCST008279-Trochanter size                                                                                                                                                            | Inverse variance weighted | 2    | -0.15579 | 0.169526 | 0.358103 | 0.998683795 | -0.48806 | 0.176479 | 0.855738 | 0.613815084 | 1.193008826 |
| GCST002128-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 5    | 0.046445 | 0.050562 | 0.358323 | 0.998683795 | -0.05266 | 0.145547 | 1.04754  | 0.948704881 | 1.156672565 |
| GCST002174-Lipid traits                                                                                                                                                               | Inverse variance weighted | 3    | 0.880982 | 0.961652 | 0.359608 | 0.998683795 | -1.00386 | 2.765821 | 2.413269 | 0.366463489 | 15.89208349 |
| GCST001615-Sclerosing cholangitis and ulcerative colitis (combined)                                                                                                                   | Inverse variance weighted | 2    | -0.04202 | 0.045978 | 0.36073  | 0.998683795 | -0.13214 | 0.048094 | 0.958848 | 0.876219867 | 1.049268837 |
| GCST005749-Digit length ratio (left hand)                                                                                                                                             | Inverse variance weighted | 6    | 0.023293 | 0.025583 | 0.362551 | 0.998683795 | -0.02685 | 0.073436 | 1.023567 | 0.973508497 | 1.076199291 |
| GCST006097-Moderate to vigorous physical activity levels                                                                                                                              | Inverse variance weighted | 5    | 10.75603 | 11.81416 | 0.362593 | 0.998683795 | -12.3997 | 33.91178 | 46912.03 | 4.11976E-06 | 5.34191E+14 |
| GCST001585-Breast size                                                                                                                                                                | Inverse variance weighted | 3    | -0.13    | 0.143547 | 0.365146 | 0.998683795 | -0.41135 | 0.151356 | 0.878098 | 0.662755544 | 1.163410298 |
| GCST004398-Lipoprotein (a) levels                                                                                                                                                     | Inverse variance weighted | 18   | -0.00148 | 0.001639 | 0.365646 | 0.998683795 | -0.0047  | 0.00173  | 0.998518 | 0.995315743 | 1.001731231 |
| GCST004003-Hematocrit                                                                                                                                                                 | Inverse variance weighted | 3    | -0.06493 | 0.071828 | 0.366006 | 0.998683795 | -0.20571 | 0.075852 | 0.937132 | 0.81406632  | 1.078802396 |
| GCST007436-Carotid intima media thickness                                                                                                                                             | Inverse variance weighted | 4    | 8.098445 | 9.019369 | 0.369242 | 0.998683795 | -9.57952 | 25.77641 | 3289.348 | 6.91302E-05 | 1.56514E+11 |
| GCST003877-Abdominal aortic aneurysm                                                                                                                                                  | Inverse variance weighted | 7    | -0.03733 | 0.041684 | 0.370469 | 0.998683795 | -0.11903 | 0.044368 | 0.963356 | 0.887779484 | 1.045367384 |
| GCST006921-Regular attendance at a pub or social club                                                                                                                                 | Inverse variance weighted | 7    | 1.154771 | 1.290342 | 0.370822 | 0.998683795 | -1.3743  | 3.68384  | 3.173296 | 0.253016959 | 39.79894803 |
| GCST000287-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 8    | -0.04242 | 0.047672 | 0.373509 | 0.998683795 | -0.13586 | 0.051013 | 0.958463 | 0.872963243 | 1.052336578 |
| GCST002446-Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)                                                                                                           | Inverse variance weighted | 3    | -0.00916 | 0.010304 | 0.373909 | 0.998683795 | -0.02936 | 0.011033 | 0.99088  | 0.9710698   | 1.01109452  |
| GCST000503-Mean corpuscular volume                                                                                                                                                    | Inverse variance weighted | 3    | -0.99207 | 1.11767  | 0.374745 | 0.998683795 | -3.1827  | 1.198567 | 0.370809 | 0.04147348  | 3.315360991 |
| GCST004365-Blood protein levels                                                                                                                                                       | Inverse variance weighted | 298  | -0.00199 | 0.00224  | 0.375324 | 0.998683795 | -0.00638 | 0.002405 | 0.998016 | 0.993642613 | 1.00240797  |
| GCST000731-Resting heart rate                                                                                                                                                         | Inverse variance weighted | 5    | -0.00096 | 0.001084 | 0.377131 | 0.998683795 | -0.00308 | 0.001167 | 0.999043 | 0.996923237 | 1.001167742 |
| GCST007933-Medication use (immunosuppressants)                                                                                                                                        | Inverse variance weighted | 2    | -0.1239  | 0.140321 | 0.377244 | 0.998683795 | -0.39893 | 0.151128 | 0.883467 | 0.671036923 | 1.163145293 |
| GCST003598-QRS duration                                                                                                                                                               | Inverse variance weighted | 15   | -0.00723 | 0.008187 | 0.377453 | 0.998683795 | -0.02327 | 0.008821 | 0.9928   | 0.976995279 | 1.008860122 |
| GCST007432-FEV1                                                                                                                                                                       | Inverse variance weighted | 109  | 0.076144 | 0.086351 | 0.37789  | 0.998683795 | -0.0931  | 0.245392 | 1.079118 | 0.9110981   | 1.278122581 |
| GCST005951-Body mass index                                                                                                                                                            | Inverse variance weighted | 123  | -0.26049 | 0.295896 | 0.378674 | 0.998683795 | -0.84045 | 0.319467 | 0.770674 | 0.431517545 | 1.376393457 |
| GCST004504-Waist circumference adjusted for BMI in non-smokers                                                                                                                        | Inverse variance weighted | 25   | -0.1262  | 0.143467 | 0.37906  | 0.998683795 | -0.40739 | 0.154997 | 0.881441 | 0.665383446 | 1.167654607 |
| GCST003643-Nose morphology                                                                                                                                                            | Inverse variance weighted | 2    | 0.041981 | 0.047761 | 0.379408 | 0.998683795 | -0.05163 | 0.135593 | 1.042875 | 0.949680096 | 1.145215298 |
| GCST006110-Nose morphology                                                                                                                                                            | Inverse variance weighted | 4    | 0.848561 | 0.965457 | 0.379444 | 0.998683795 | -1.04374 | 2.740858 | 2.336283 | 0.352136948 | 15.50027741 |
| GCST001363-Atopic dermatitis                                                                                                                                                          | Inverse variance weighted | 2    | 0.081507 | 0.092785 | 0.379699 | 0.998683795 | -0.10035 | 0.263365 | 1.08492  | 0.904519681 | 1.301301073 |
| GCST002546-Osteoprotegerin levels                                                                                                                                                     | Inverse variance weighted | 2    | -0.34075 | 0.388414 | 0.380329 | 0.998683795 | -1.10204 | 0.420539 | 0.711235 | 0.332191811 | 1.522782503 |
| GCST008086-LDL cholesterol levels in current drinkers                                                                                                                                 | Inverse variance weighted | 24   | 0.003289 | 0.003751 | 0.380535 | 0.998683795 | -0.00406 | 0.010641 | 1.003295 | 0.995945513 | 1.01069823  |
| GCST007985-Snoring                                                                                                                                                                    | Inverse variance weighted | 21   | 0.107539 | 0.12267  | 0.380674 | 0.998683795 | -0.13289 | 0.347971 | 1.113534 | 0.875558192 | 1.41619186  |
| GCST003123-Severe influenza A (H1N1) infection                                                                                                                                        | Inverse variance weighted | 3    | -0.00872 | 0.009952 | 0.38094  | 0.998683795 | -0.02822 | 0.010786 | 0.991319 | 0.972170217 | 1.010844256 |
| GCST003524-Endometrial cancer                                                                                                                                                         | Inverse variance weighted | 4    | 0.051038 | 0.058319 | 0.381492 | 0.998683795 | -0.06327 | 0.165344 | 1.052363 | 0.938692069 | 1.17979912  |
| GCST004137-Optic cup area                                                                                                                                                             | Inverse variance weighted | 13   | -0.37638 | 0.431611 | 0.383195 | 0.998683795 | -1.22233 | 0.469582 | 0.686344 | 0.294541936 | 1.599325583 |
| GCST004480-High-grade serous ovarian cancer                                                                                                                                           | Inverse variance weighted | 5    | -0.04854 | 0.055783 | 0.384222 | 0.998683795 | -0.15787 | 0.060796 | 0.95262  | 0.853956755 | 1.062681878 |
| GCST001614-Central corneal thickness                                                                                                                                                  | Inverse variance weighted | 2    | 0.066827 | 0.07681  | 0.384287 | 0.998683795 | -0.08372 | 0.217374 | 1.06911  | 0.919687789 | 1.242809294 |
| GCST001148-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 4    | 0.190933 | 0.21973  | 0.384876 | 0.998683795 | -0.23974 | 0.621604 | 1.210379 | 0.786834961 | 1.861911298 |
| GCST004478-Serous invasive ovarian cancer                                                                                                                                             | Inverse variance weighted | 5    | -0.04901 | 0.056425 | 0.385109 | 0.998683795 | -0.1596  | 0.061587 | 0.952175 | 0.852484463 | 1.063523118 |
| GCST007323-Risk-taking tendency (4-domain principal component model)                                                                                                                  | Inverse variance weighted | 52   | -0.17048 | 0.196318 | 0.385188 | 0.998683795 | -0.55526 | 0.214305 | 0.843262 | 0.573922681 | 1.239000382 |
| GCST001779-Hematology traits                                                                                                                                                          | Inverse variance weighted | 3    | -0.21521 | 0.248103 | 0.385712 | 0.998683795 | -0.70149 | 0.271073 | 0.806372 | 0.495844964 | 1.311370635 |
| GCST003043-Inflammatory bowel disease                                                                                                                                                 | Inverse variance weighted | 35   | -0.02786 | 0.032125 | 0.385766 | 0.998683795 | -0.09083 | 0.035103 | 0.972522 | 0.91317462  | 1.035725866 |
| GCST002702-Height                                                                                                                                                                     | Inverse variance weighted | 60   | -0.04488 | 0.051804 | 0.386307 | 0.998683795 | -0.14642 | 0.056657 | 0.956112 | 0.863797793 | 1.058292503 |
| GCST003875-Gut microbiota (bacterial taxa)                                                                                                                                            | Inverse variance weighted | 28   | -0.00579 | 0.006691 | 0.386795 | 0.998683795 | -0.0189  | 0.007323 | 0.994226 | 0.981273818 | 1.007350044 |
| GCST005656-IgG glycosylation patterns                                                                                                                                                 | Inverse variance weighted | 31   | 0.008964 | 0.010369 | 0.387331 | 0.998683795 | -0.01136 | 0.029288 | 1.009004 | 0.988704377 | 1.029720879 |
| GCST004180-Pediatric bone mineral content (hip)                                                                                                                                       | Inverse variance weighted | 2    | -0.07959 | 0.092962 | 0.391925 | 0.998683795 | -0.26179 | 0.102618 | 0.923497 | 0.769669382 | 1.108068216 |
| GCST002783-Body mass index                                                                                                                                                            | Inverse variance weighted | 74   | -0.36166 | 0.422877 | 0.392425 | 0.998683795 | -1.1905  | 0.467183 | 0.696522 | 0.304070575 | 1.595493779 |
| GCST002925-Sex hormone levels                                                                                                                                                         | Inverse variance weighted | 4    | -0.06634 | 0.077862 | 0.394235 | 0.998683795 | -0.21894 | 0.086274 | 0.935817 | 0.803366123 | 1.090104923 |
| GCST004616-Platelet distribution width                                                                                                                                                | Inverse variance weighted | 89   | -0.04037 | 0.047426 | 0.394601 | 0.998683795 | -0.13333 | 0.052581 | 0.96043  | 0.875176471 | 1.053988309 |
| GCST004863-Mosquito bite size                                                                                                                                                         | Inverse variance weighted | 14   | -0.14636 | 0.172201 | 0.39535  | 0.998683795 | -0.48388 | 0.191151 | 0.863844 | 0.616389009 | 1.210641909 |
| GCST001047-Soluble ICAM-1                                                                                                                                                             | Inverse variance weighted | 2    | 0.00067  | 0.00079  | 0.396158 | 0.998683795 | -0.00088 | 0.002219 | 1.000671 | 0.999122196 | 1.002221452 |
| GCST007994-Asthma (age of onset)                                                                                                                                                      | Inverse variance weighted | 8    | 0.004143 | 0.004884 | 0.396362 | 0.998683795 | -0.00543 | 0.013716 | 1.004151 | 0.994584096 | 1.013810155 |
| GCST004206-Fasting plasma glucose                                                                                                                                                     | Inverse variance weighted | 5    | 0.066306 | 0.078243 | 0.396747 | 0.998683795 | -0.08705 | 0.219662 | 1.068554 | 0.916632102 | 1.245655333 |
| GCST001942-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 14   | -0.04537 | 0.053565 | 0.396953 | 0.998683795 | -0.15036 | 0.059614 | 0.95564  | 0.860397344 | 1.061426488 |
| GCST000439-Glioma                                                                                                                                                                     | Inverse variance weighted | 3    | -0.07225 | 0.085338 | 0.397186 | 0.998683795 | -0.23951 | 0.09501  | 0.930296 | 0.787010045 | 1.099670235 |
| GCST001862-Sickle cell anemia (haemolysis)                                                                                                                                            | Inverse variance weighted | 2    | -0.02426 | 0.028676 | 0.397585 | 0.998683795 | -0.08046 | 0.031947 | 0.976034 | 0.922689272 | 1.032462282 |
| GCST000805-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 3    | 0.26289  | 0.31087  | 0.397744 | 0.998683795 | -0.34642 | 0.872196 | 1.300683 | 0.707218174 | 2.39215762  |
| GCST001666-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 6    | 0.043617 | 0.051594 | 0.397896 | 0.998683795 | -0.05751 | 0.144741 | 1.044582 | 0.944114913 | 1.155739997 |
| GCST000494-Bone mineral density (spine)                                                                                                                                               | Inverse variance weighted | 7    | -0.05998 | 0.071015 | 0.398357 | 0.998683795 | -0.19916 | 0.079213 | 0.941787 | 0.819414728 | 1.082434484 |
| GCST006020-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 16   | -0.02594 | 0.03074  | 0.398716 | 0.998683795 | -0.08619 | 0.034308 | 0.974392 | 0.91741832  | 1.034903428 |
| GCST004176-Pediatric areal bone mineral density (radius)                                                                                                                              | Inverse variance weighted | 2    | -0.0361  | 0.042798 | 0.398967 | 0.998683795 | -0.11998 | 0.047785 | 0.964545 | 0.886935773 | 1.048945479 |
| GCST008302-Number of decayed, missing and filled tooth surfaces                                                                                                                       | Inverse variance weighted | 2    | 0.271982 | 0.323161 | 0.399995 | 0.998683795 | -0.36141 | 0.905377 | 1.312563 | 0.696690796 | 2.472864206 |
| GCST007429-Lung function (FVC)                                                                                                                                                        | Inverse variance weighted | 85   | 0.093817 | 0.111606 | 0.400564 | 0.998683795 | -0.12493 | 0.312565 | 1.098359 | 0.882558543 | 1.366926832 |
| GCST003766-Subjective well-being                                                                                                                                                      | Inverse variance weighted | 4    | 0.420123 | 0.500178 | 0.400938 | 0.998683795 | -0.56023 | 1.400472 | 1.522149 | 0.571079749 | 4.057116175 |
| GCST004352-Early onset atrial fibrillation                                                                                                                                            | Inverse variance weighted | 3    | -0.02111 | 0.025171 | 0.401593 | 0.998683795 | -0.07045 | 0.028222 | 0.979109 | 0.931977086 | 1.028623814 |
| GCST001550-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 5    | 0.041508 | 0.049492 | 0.401647 | 0.998683795 | -0.0555  | 0.138511 | 1.042381 | 0.946016106 | 1.148562534 |
| GCST007877-Creatinine levels                                                                                                                                                          | Inverse variance weighted | 13   | -0.08868 | 0.105759 | 0.401739 | 0.998683795 | -0.29597 | 0.118607 | 0.915137 | 0.743809976 | 1.125927293 |
| GCST005850-Heart rate response to recovery post exercise (30 sec)                                                                                                                     | Inverse variance weighted | 9    | -0.10099 | 0.120563 | 0.402234 | 0.998683795 | -0.33729 | 0.135316 | 0.903944 | 0.713700225 | 1.144897987 |
| GCST002352-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 21   | 0.043932 | 0.052615 | 0.403732 | 0.998683795 | -0.05919 | 0.147057 | 1.044911 | 0.942524798 | 1.158420194 |
| GCST000649-Chronic kidney disease                                                                                                                                                     | Inverse variance weighted | 14   | -0.01278 | 0.01532  | 0.404065 | 0.998683795 | -0.04281 | 0.017244 | 0.987299 | 0.958094724 | 1.017393447 |
| GCST002897-Triglycerides                                                                                                                                                              | Inverse variance weighted | 23   | -0.0516  | 0.061939 | 0.404774 | 0.998683795 | -0.173   | 0.069798 | 0.949706 | 0.841134454 | 1.072291208 |
| GCST007431-Lung function (FEV1/FVC)                                                                                                                                                   | Inverse variance weighted | 96   | 0.054918 | 0.06614  | 0.406359 | 0.998683795 | -0.07472 | 0.184553 | 1.056453 | 0.92800563  | 1.202680155 |
| GCST001228-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 6    | -0.01899 | 0.02289  | 0.406718 | 0.998683795 | -0.06386 | 0.025873 | 0.981188 | 0.938139536 | 1.026210882 |
| GCST005848-Heart rate response to recovery post exercise (50 sec)                                                                                                                     | Inverse variance weighted | 13   | -0.08635 | 0.1044   | 0.408173 | 0.998683795 | -0.29098 | 0.118274 | 0.917272 | 0.747533769 | 1.125552389 |
| GCST004519-Body mass index (adult)                                                                                                                                                    | Inverse variance weighted | 6    | -0.14594 | 0.176545 | 0.408433 | 0.998683795 | -0.49197 | 0.200086 | 0.864208 | 0.611420968 | 1.221508049 |
| GCST007464-Smoking cessation (MTAG)                                                                                                                                                   | Inverse variance weighted | 46   | -0.17738 | 0.21501  | 0.409392 | 0.998683795 | -0.59879 | 0.244044 | 0.837466 | 0.549473895 | 1.276400027 |
| GCST004064-Waist-hip ratio                                                                                                                                                            | Inverse variance weighted | 28   | -0.89006 | 1.079717 | 0.409743 | 0.998683795 | -3.0063  | 1.226185 | 0.410631 | 0.0494742   | 3.408202529 |
| GCST003360-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 3    | 0.017972 | 0.021815 | 0.410043 | 0.998683795 | -0.02479 | 0.06073  | 1.018134 | 0.975518343 | 1.06261214  |
| GCST001526-Fasting blood insulin (BMI interaction)                                                                                                                                    | Inverse variance weighted | 7    | -3.50422 | 4.261746 | 0.410935 | 0.998683795 | -11.8572 | 4.848806 | 0.03007  | 7.08707E-06 | 127.5879394 |
| GCST004276-Plasma thyroid-stimulating hormone levels                                                                                                                                  | Inverse variance weighted | 2    | 0.048963 | 0.059563 | 0.411058 | 0.998683795 | -0.06778 | 0.165706 | 1.050181 | 0.934465646 | 1.180225507 |
| GCST004864-Perceived unattractiveness to mosquitoes                                                                                                                                   | Inverse variance weighted | 4    | -0.03848 | 0.046814 | 0.411131 | 0.998683795 | -0.13023 | 0.053278 | 0.962254 | 0.877892283 | 1.054723326 |
| GCST004651-Aortic root size                                                                                                                                                           | Inverse variance weighted | 5    | 0.393232 | 0.479324 | 0.411994 | 0.998683795 | -0.54624 | 1.332707 | 1.481763 | 0.579121993 | 3.791292881 |
| GCST004620-Sum basophil neutrophil counts                                                                                                                                             | Inverse variance weighted | 64   | -0.07059 | 0.086069 | 0.412143 | 0.998683795 | -0.23928 | 0.098107 | 0.931846 | 0.787192476 | 1.103081355 |
| GCST004279-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 18   | 0.013295 | 0.016221 | 0.412412 | 0.998683795 | -0.0185  | 0.045088 | 1.013384 | 0.981672814 | 1.046119965 |
| GCST001887-Monocyte count                                                                                                                                                             | Inverse variance weighted | 3    | -0.08625 | 0.105257 | 0.412522 | 0.998683795 | -0.29256 | 0.120049 | 0.917361 | 0.746352932 | 1.127552059 |
| GCST004865-Itch intensity from mosquito bite adjusted by bite size                                                                                                                    | Inverse variance weighted | 12   | 0.146883 | 0.179495 | 0.413181 | 0.998683795 | -0.20493 | 0.498693 | 1.158218 | 0.81470606  | 1.646567831 |
| GCST005905-Global electrical heterogeneity phenotypes                                                                                                                                 | Inverse variance weighted | 7    | -0.0581  | 0.071029 | 0.413351 | 0.998683795 | -0.19732 | 0.081115 | 0.943553 | 0.820927389 | 1.084495526 |
| GCST007468-Smoking initiation (ever regular vs never regular) (MTAG)                                                                                                                  | Inverse variance weighted | 391  | -0.09687 | 0.118452 | 0.413473 | 0.998683795 | -0.32903 | 0.135296 | 0.907675 | 0.71961814  | 1.14487552  |
| GCST002636-Diffuse large B cell lymphoma                                                                                                                                              | Inverse variance weighted | 3    | -0.04426 | 0.054301 | 0.415064 | 0.998683795 | -0.15069 | 0.062174 | 0.956709 | 0.860117619 | 1.064147409 |
| GCST004748-Lung cancer                                                                                                                                                                | Inverse variance weighted | 21   | -0.03454 | 0.042385 | 0.415094 | 0.998683795 | -0.11762 | 0.048533 | 0.966047 | 0.889035585 | 1.04973     |
| GCST001884-Age-related macular degeneration                                                                                                                                           | Inverse variance weighted | 9    | 0.011071 | 0.013641 | 0.417002 | 0.998683795 | -0.01566 | 0.037808 | 1.011133 | 0.98445723  | 1.038531562 |
| GCST006228-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 6    | -0.01733 | 0.021357 | 0.417065 | 0.998683795 | -0.05919 | 0.024528 | 0.982818 | 0.942527064 | 1.024830958 |
| GCST001500-Wilms tumor                                                                                                                                                                | Inverse variance weighted | 5    | 0.027938 | 0.034503 | 0.418088 | 0.998683795 | -0.03969 | 0.095564 | 1.028332 | 0.961090114 | 1.100279191 |
| GCST001740-Lung cancer                                                                                                                                                                | Inverse variance weighted | 4    | -0.07381 | 0.091583 | 0.42031  | 0.998683795 | -0.25331 | 0.105698 | 0.928853 | 0.776228483 | 1.111485857 |
| GCST004895-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 2    | 0.060257 | 0.074849 | 0.420794 | 0.998683795 | -0.08645 | 0.20696  | 1.062109 | 0.9171841   | 1.229933928 |
| GCST001236-Blood pressure                                                                                                                                                             | Inverse variance weighted | 13   | -0.01204 | 0.01496  | 0.421045 | 0.998683795 | -0.04136 | 0.017285 | 0.988035 | 0.959483713 | 1.017435463 |
| GCST004184-Lung function (FVC)                                                                                                                                                        | Inverse variance weighted | 8    | -0.20912 | 0.260224 | 0.421626 | 0.998683795 | -0.71915 | 0.300922 | 0.811301 | 0.487163804 | 1.351103456 |
| GCST005337-Headache                                                                                                                                                                   | Inverse variance weighted | 18   | -0.29644 | 0.369035 | 0.421816 | 0.998683795 | -1.01975 | 0.426872 | 0.743463 | 0.360686607 | 1.532456902 |
| GCST006290-Myopia (age of diagnosis)                                                                                                                                                  | Inverse variance weighted | 42   | 0.034991 | 0.043626 | 0.422512 | 0.998683795 | -0.05052 | 0.120498 | 1.035611 | 0.950738794 | 1.12805882  |
| GCST000569-Two-hour glucose challenge                                                                                                                                                 | Inverse variance weighted | 2    | 0.122793 | 0.153266 | 0.423031 | 0.998683795 | -0.17761 | 0.423194 | 1.13065  | 0.837270165 | 1.526830395 |
| GCST004904-Body mass index                                                                                                                                                            | Inverse variance weighted | 164  | -0.03625 | 0.045317 | 0.423807 | 0.998683795 | -0.12507 | 0.052575 | 0.964403 | 0.882438479 | 1.053981296 |
| GCST004749-Lung cancer in ever smokers                                                                                                                                                | Inverse variance weighted | 11   | -0.03753 | 0.046966 | 0.424294 | 0.998683795 | -0.12958 | 0.054528 | 0.96317  | 0.878465834 | 1.056041527 |
| GCST004415-Invasive epithelial ovarian cancer                                                                                                                                         | Inverse variance weighted | 3    | -0.0744  | 0.093148 | 0.424438 | 0.998683795 | -0.25697 | 0.108168 | 0.928299 | 0.773390971 | 1.114234932 |
| GCST007441-Total cholesterol levels                                                                                                                                                   | Inverse variance weighted | 4    | -0.00206 | 0.002577 | 0.424762 | 0.998683795 | -0.00711 | 0.002994 | 0.997945 | 0.992916706 | 1.002998756 |
| GCST002201-Calcium levels                                                                                                                                                             | Inverse variance weighted | 6    | -0.22551 | 0.282572 | 0.424845 | 0.998683795 | -0.77935 | 0.328336 | 0.798113 | 0.458705467 | 1.388656111 |
| GCST007400-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 15   | 0.019707 | 0.024746 | 0.425805 | 0.998683795 | -0.02879 | 0.068209 | 1.019903 | 0.971616403 | 1.070588563 |
| GCST004510-Sporadic neuroblastoma                                                                                                                                                     | Inverse variance weighted | 6    | -0.02338 | 0.029412 | 0.426563 | 0.998683795 | -0.08103 | 0.034262 | 0.976886 | 0.92216419  | 1.034855872 |
| GCST001706-Stroke (ischemic)                                                                                                                                                          | Inverse variance weighted | 2    | -0.04201 | 0.052884 | 0.427013 | 0.998683795 | -0.14566 | 0.061646 | 0.958864 | 0.864452886 | 1.063585696 |
| GCST002544-Parkinson's disease                                                                                                                                                        | Inverse variance weighted | 18   | -0.03929 | 0.04963  | 0.428518 | 0.998683795 | -0.13657 | 0.057981 | 0.961469 | 0.872347033 | 1.059694942 |
| GCST007437-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 3    | 2.953403 | 3.731085 | 0.428613 | 0.998683795 | -4.35952 | 10.26633 | 19.17107 | 0.012784473 | 28748.16054 |
| GCST000646-Intracranial aneurysm                                                                                                                                                      | Inverse variance weighted | 4    | -0.03545 | 0.044792 | 0.428711 | 0.998683795 | -0.12324 | 0.052344 | 0.965172 | 0.88405003  | 1.053738533 |
| GCST007614-C-reactive protein levels                                                                                                                                                  | Inverse variance weighted | 31   | -0.08288 | 0.104834 | 0.429168 | 0.998683795 | -0.28836 | 0.122592 | 0.920458 | 0.749492354 | 1.130422752 |
| GCST005145-Glycated hemoglobin levels                                                                                                                                                 | Inverse variance weighted | 3    | -0.23701 | 0.300415 | 0.430139 | 0.998683795 | -0.82583 | 0.3518   | 0.78898  | 0.437872714 | 1.421623501 |
| GCST002899-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 17   | -0.67917 | 0.860956 | 0.430194 | 0.998683795 | -2.36665 | 1.008301 | 0.507036 | 0.093794663 | 2.740940568 |
| GCST005185-Fasting blood insulin                                                                                                                                                      | Inverse variance weighted | 3    | 0.403554 | 0.511651 | 0.430271 | 0.998683795 | -0.59928 | 1.406389 | 1.497135 | 0.549205626 | 4.081193342 |
| GCST005288-Extrinsic epigenetic age acceleration                                                                                                                                      | Inverse variance weighted | 2    | 0.02548  | 0.03233  | 0.430623 | 0.998683795 | -0.03789 | 0.088848 | 1.025808 | 0.962821698 | 1.092914219 |
| GCST007354-Intracranial aneurysm                                                                                                                                                      | Inverse variance weighted | 11   | -0.00851 | 0.010799 | 0.430706 | 0.998683795 | -0.02968 | 0.012657 | 0.991526 | 0.970759233 | 1.012737608 |
| GCST000935-Iron status biomarkers                                                                                                                                                     | Inverse variance weighted | 2    | -0.00051 | 0.000645 | 0.432103 | 0.998683795 | -0.00177 | 0.000757 | 0.999494 | 0.998231425 | 1.000757447 |
| GCST001746-QT interval                                                                                                                                                                | Inverse variance weighted | 2    | -0.00409 | 0.005217 | 0.432939 | 0.998683795 | -0.01432 | 0.006134 | 0.995917 | 0.985785598 | 1.006153165 |
| GCST002346-Breast cancer (early onset)                                                                                                                                                | Inverse variance weighted | 10   | -0.0256  | 0.032678 | 0.433465 | 0.998683795 | -0.08964 | 0.038453 | 0.974729 | 0.914256604 | 1.039201511 |
| GCST008059-Estimated glomerular filtration rate                                                                                                                                       | Inverse variance weighted | 150  | -0.4128  | 0.528191 | 0.434483 | 0.998683795 | -1.44806 | 0.62245  | 0.661792 | 0.235026511 | 1.863487682 |
| GCST002559-Vitamin B levels in ischemic stroke                                                                                                                                        | Inverse variance weighted | 2    | 0.05356  | 0.06867  | 0.435418 | 0.998683795 | -0.08103 | 0.188153 | 1.05502  | 0.92216221  | 1.207018757 |
| GCST002318-Rheumatoid arthritis                                                                                                                                                       | Inverse variance weighted | 47   | 0.020781 | 0.026646 | 0.435456 | 0.998683795 | -0.03144 | 0.073006 | 1.020998 | 0.969044422 | 1.075737194 |
| GCST001273-Lipoprotein-associated phospholipase A2 activity and mass                                                                                                                  | Inverse variance weighted | 4    | 0.24298  | 0.311797 | 0.43581  | 0.998683795 | -0.36814 | 0.854102 | 1.275043 | 0.692018297 | 2.349264171 |
| GCST007389-Suicidality                                                                                                                                                                | Inverse variance weighted | 2    | 0.180107 | 0.231415 | 0.436402 | 0.998683795 | -0.27347 | 0.63368  | 1.197345 | 0.76073733  | 1.884533705 |
| GCST000925-N-glycan levels                                                                                                                                                            | Inverse variance weighted | 4    | 0.040302 | 0.05181  | 0.43664  | 0.998683795 | -0.06125 | 0.141849 | 1.041125 | 0.940592559 | 1.152402158 |
| GCST002961-Acylcarnitine levels                                                                                                                                                       | Inverse variance weighted | 8    | -0.05137 | 0.066086 | 0.437011 | 0.998683795 | -0.18089 | 0.078163 | 0.949932 | 0.834524758 | 1.081298683 |
| GCST001474-Hypothyroidism                                                                                                                                                             | Inverse variance weighted | 3    | 0.0443   | 0.057011 | 0.437135 | 0.998683795 | -0.06744 | 0.156041 | 1.045296 | 0.934782327 | 1.168874262 |
| GCST004295-Atrial fibrillation                                                                                                                                                        | Inverse variance weighted | 2    | 0.086293 | 0.111075 | 0.437222 | 0.998683795 | -0.13141 | 0.303999 | 1.090126 | 0.876855458 | 1.355267992 |
| GCST001790-Gout                                                                                                                                                                       | Inverse variance weighted | 2    | 0.023334 | 0.030053 | 0.437487 | 0.998683795 | -0.03557 | 0.082238 | 1.023609 | 0.96505598  | 1.085713857 |
| GCST000154-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 4    | -0.04716 | 0.060749 | 0.437537 | 0.998683795 | -0.16623 | 0.071905 | 0.953932 | 0.846851086 | 1.074552914 |
| GCST005750-Digit length ratio                                                                                                                                                         | Inverse variance weighted | 7    | 0.018277 | 0.023593 | 0.438545 | 0.998683795 | -0.02797 | 0.06452  | 1.018445 | 0.97242094  | 1.066646892 |
| GCST003214-Cholesterol, total                                                                                                                                                         | Inverse variance weighted | 5    | -0.00281 | 0.003627 | 0.438564 | 0.998683795 | -0.00992 | 0.004299 | 0.997195 | 0.990131182 | 1.004308349 |
| GCST002481-Acne (severe)                                                                                                                                                              | Inverse variance weighted | 3    | 0.070344 | 0.090867 | 0.438845 | 0.998683795 | -0.10775 | 0.248443 | 1.072877 | 0.897847829 | 1.282027592 |
| GCST008258-Alcohol use disorder (consumption score)                                                                                                                                   | Inverse variance weighted | 14   | -0.00098 | 0.001267 | 0.438851 | 0.998683795 | -0.00346 | 0.001502 | 0.99902  | 0.996542677 | 1.001503257 |
| GCST000999-Coronary heart disease                                                                                                                                                     | Inverse variance weighted | 5    | -0.07076 | 0.091553 | 0.439608 | 0.998683795 | -0.2502  | 0.108687 | 0.931688 | 0.778644359 | 1.114812912 |
| GCST003298-NT-proBNP levels in acute coronary syndrome                                                                                                                                | Inverse variance weighted | 2    | 0.056274 | 0.072845 | 0.439812 | 0.998683795 | -0.0865  | 0.19905  | 1.057887 | 0.917132826 | 1.220243472 |
| GCST006919-Ability to confide in someone                                                                                                                                              | Inverse variance weighted | 2    | 1.394197 | 1.805798 | 0.440075 | 0.998683795 | -2.14517 | 4.933562 | 4.031736 | 0.117048411 | 138.8732425 |
| GCST004602-Mean corpuscular volume                                                                                                                                                    | Inverse variance weighted | 134  | 0.026476 | 0.034301 | 0.440189 | 0.998683795 | -0.04075 | 0.093705 | 1.026829 | 0.960065655 | 1.098236152 |
| GCST001814-Age-related macular degeneration                                                                                                                                           | Inverse variance weighted | 2    | 0.02557  | 0.033168 | 0.440759 | 0.998683795 | -0.03944 | 0.09058  | 1.0259   | 0.961327399 | 1.094809292 |
| GCST000214-Restless legs syndrome                                                                                                                                                     | Inverse variance weighted | 2    | 0.036789 | 0.047917 | 0.442619 | 0.998683795 | -0.05713 | 0.130707 | 1.037475 | 0.944473588 | 1.139633301 |
| GCST005748-Digit length ratio (right hand)                                                                                                                                            | Inverse variance weighted | 6    | 0.020337 | 0.026528 | 0.443304 | 0.998683795 | -0.03166 | 0.072332 | 1.020545 | 0.968837857 | 1.075012518 |
| GCST006395-Glaucoma                                                                                                                                                                   | Inverse variance weighted | 15   | -0.02577 | 0.03369  | 0.444323 | 0.998683795 | -0.0918  | 0.040263 | 0.974559 | 0.912284318 | 1.041084523 |
| GCST001454-Rheumatoid arthritis                                                                                                                                                       | Inverse variance weighted | 8    | 0.045248 | 0.059213 | 0.44477  | 0.998683795 | -0.07081 | 0.161305 | 1.046287 | 0.931640245 | 1.175042862 |
| GCST007944-Medication use (antiglaucoma preparations and miotics)                                                                                                                     | Inverse variance weighted | 11   | 0.026187 | 0.034288 | 0.445022 | 0.998683795 | -0.04102 | 0.093392 | 1.026533 | 0.959812323 | 1.097891906 |
| GCST000952-Breast cancer                                                                                                                                                              | Inverse variance weighted | 5    | 0.038349 | 0.050271 | 0.445557 | 0.998683795 | -0.06018 | 0.13688  | 1.039094 | 0.941592754 | 1.146690931 |
| GCST000580-Platelet count                                                                                                                                                             | Inverse variance weighted | 4    | 0.002881 | 0.003787 | 0.44668  | 0.998683795 | -0.00454 | 0.010303 | 1.002886 | 0.99547003  | 1.010356406 |
| GCST003180-Atopic march                                                                                                                                                               | Inverse variance weighted | 5    | 0.023191 | 0.030644 | 0.449188 | 0.998683795 | -0.03687 | 0.083254 | 1.023462 | 0.963799134 | 1.086817826 |
| GCST000420-Rheumatoid arthritis                                                                                                                                                       | Inverse variance weighted | 3    | -0.06491 | 0.085854 | 0.449648 | 0.998683795 | -0.23318 | 0.103368 | 0.937155 | 0.792010588 | 1.108899795 |
| GCST007704-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 49   | -0.00611 | 0.008089 | 0.449749 | 0.998683795 | -0.02197 | 0.00974  | 0.993905 | 0.97827159  | 1.009787912 |
| GCST004457-Growth-regulated protein alpha levels                                                                                                                                      | Inverse variance weighted | 5    | 0.019181 | 0.025406 | 0.450252 | 0.998683795 | -0.03061 | 0.068977 | 1.019366 | 0.969849761 | 1.071411179 |
| GCST000038-Type 1 diabetes                                                                                                                                                            | Inverse variance weighted | 7    | 0.017255 | 0.022867 | 0.450507 | 0.998683795 | -0.02756 | 0.062074 | 1.017404 | 0.972811822 | 1.064041233 |
| GCST002250-Blood pressure measurement (low sodium intervention)                                                                                                                       | Inverse variance weighted | 3    | 0.002114 | 0.002802 | 0.450662 | 0.998683795 | -0.00338 | 0.007606 | 1.002116 | 0.996626949 | 1.007635439 |
| GCST002964-Sphingolipid levels                                                                                                                                                        | Inverse variance weighted | 3    | 0.17535  | 0.232541 | 0.450812 | 0.998683795 | -0.28043 | 0.631131 | 1.191664 | 0.755458823 | 1.879735047 |
| GCST001247-Cardiovascular disease risk factors                                                                                                                                        | Inverse variance weighted | 15   | 0.235322 | 0.312697 | 0.451717 | 0.998683795 | -0.37756 | 0.848208 | 1.265316 | 0.685528881 | 2.335458863 |
| GCST007295-Body fat distribution (leg fat ratio)                                                                                                                                      | Inverse variance weighted | 39   | -0.09473 | 0.126041 | 0.452291 | 0.998683795 | -0.34177 | 0.152308 | 0.909616 | 0.710509337 | 1.16451884  |
| GCST004066-Hip circumference                                                                                                                                                          | Inverse variance weighted | 47   | -0.07922 | 0.105458 | 0.452547 | 0.998683795 | -0.28591 | 0.12748  | 0.923839 | 0.751327103 | 1.135961815 |
| GCST003228-Glioma                                                                                                                                                                     | Inverse variance weighted | 2    | -0.06386 | 0.085042 | 0.452715 | 0.998683795 | -0.23054 | 0.102824 | 0.938139 | 0.794105    | 1.10829667  |
| GCST006952-Feeling tense                                                                                                                                                              | Inverse variance weighted | 14   | 0.000693 | 0.000923 | 0.452784 | 0.998683795 | -0.00112 | 0.002501 | 1.000693 | 0.998885103 | 1.002503858 |
| GCST004065-Waist circumference                                                                                                                                                        | Inverse variance weighted | 35   | -0.64863 | 0.864599 | 0.453132 | 0.998683795 | -2.34324 | 1.045989 | 0.522764 | 0.096015959 | 2.846211962 |
| GCST008158-Body mass index                                                                                                                                                            | Inverse variance weighted | 8    | -0.22876 | 0.305071 | 0.453331 | 0.998683795 | -0.8267  | 0.369175 | 0.795516 | 0.437488649 | 1.446540369 |
| GCST000152-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 5    | -0.03895 | 0.052037 | 0.454102 | 0.998683795 | -0.14095 | 0.063038 | 0.961795 | 0.868535714 | 1.065067056 |
| GCST003017-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 5    | -0.05367 | 0.071775 | 0.454625 | 0.998683795 | -0.19435 | 0.087011 | 0.947746 | 0.823371437 | 1.090908971 |
| GCST002940-Sporadic pituitary adenoma                                                                                                                                                 | Inverse variance weighted | 3    | 0.026197 | 0.035054 | 0.454868 | 0.998683795 | -0.04251 | 0.094902 | 1.026543 | 0.958381899 | 1.099551214 |
| GCST006670-Primary sclerosing cholangitis                                                                                                                                             | Inverse variance weighted | 10   | -0.01932 | 0.025916 | 0.455937 | 0.998683795 | -0.07012 | 0.031473 | 0.980864 | 0.932285706 | 1.031973546 |
| GCST001481-Brain structure                                                                                                                                                            | Inverse variance weighted | 2    | -2.8E-06 | 3.7E-06  | 0.456625 | 0.998683795 | -1E-05   | 4.5E-06  | 0.999997 | 0.999989996 | 1.000004497 |
| GCST003304-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 5    | -0.12391 | 0.16658  | 0.456968 | 0.998683795 | -0.45041 | 0.202586 | 0.883459 | 0.637368814 | 1.224565908 |
| GCST004412-Craniofacial microsomia                                                                                                                                                    | Inverse variance weighted | 6    | -0.0099  | 0.013324 | 0.457453 | 0.998683795 | -0.03602 | 0.016215 | 0.990148 | 0.964624672 | 1.016347195 |
| GCST002449-Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid)                                                                                                        | Inverse variance weighted | 3    | 0.005365 | 0.007223 | 0.45763  | 0.998683795 | -0.00879 | 0.019523 | 1.00538  | 0.99124595  | 1.019714793 |
| GCST006959-Rheumatoid arthritis                                                                                                                                                       | Inverse variance weighted | 35   | -0.01597 | 0.021523 | 0.457959 | 0.998683795 | -0.05816 | 0.02621  | 0.984153 | 0.943500249 | 1.026556477 |
| GCST002186-Platelet count                                                                                                                                                             | Inverse variance weighted | 3    | 0.001117 | 0.001506 | 0.458214 | 0.998683795 | -0.00183 | 0.00407  | 1.001118 | 0.998166685 | 1.004078021 |
| GCST007990-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 11   | -0.04246 | 0.057398 | 0.459445 | 0.998683795 | -0.15496 | 0.07004  | 0.958428 | 0.856447663 | 1.072550899 |
| GCST004145-Primary biliary cholangitis                                                                                                                                                | Inverse variance weighted | 4    | 0.018578 | 0.025159 | 0.460259 | 0.998683795 | -0.03073 | 0.06789  | 1.018752 | 0.969733739 | 1.070247104 |
| GCST001142-Vitamin E levels                                                                                                                                                           | Inverse variance weighted | 2    | -0.42374 | 0.573972 | 0.460359 | 0.998683795 | -1.54872 | 0.701247 | 0.654595 | 0.212519099 | 2.0162655   |
| GCST003453-Chronotype                                                                                                                                                                 | Inverse variance weighted | 4    | -0.21893 | 0.297537 | 0.461854 | 0.998683795 | -0.8021  | 0.364246 | 0.80338  | 0.44838614  | 1.439427951 |
| GCST007133-Triglycerides                                                                                                                                                              | Inverse variance weighted | 10   | 0.215351 | 0.293475 | 0.463072 | 0.998683795 | -0.35986 | 0.790561 | 1.240297 | 0.697774373 | 2.204633117 |
| GCST005215-Corrected insulin response                                                                                                                                                 | Inverse variance weighted | 4    | 0.070775 | 0.096499 | 0.463298 | 0.998683795 | -0.11836 | 0.259912 | 1.07334  | 0.888373718 | 1.296816567 |
| GCST000914-Polycystic ovary syndrome                                                                                                                                                  | Inverse variance weighted | 5    | 0.021067 | 0.028797 | 0.464431 | 0.998683795 | -0.03537 | 0.077508 | 1.02129  | 0.965243798 | 1.080590894 |
| GCST004161-Vitamin B12 levels                                                                                                                                                         | Inverse variance weighted | 3    | -0.0901  | 0.123421 | 0.46539  | 0.998683795 | -0.332   | 0.151808 | 0.913842 | 0.717484901 | 1.163936885 |
| GCST000584-Triglycerides                                                                                                                                                              | Inverse variance weighted | 3    | -0.05836 | 0.08012  | 0.466342 | 0.998683795 | -0.2154  | 0.098673 | 0.943307 | 0.8062195   | 1.103705142 |
| GCST004297-Atrial fibrillation                                                                                                                                                        | Inverse variance weighted | 11   | 0.038192 | 0.052431 | 0.466355 | 0.998683795 | -0.06457 | 0.140957 | 1.038931 | 0.937467816 | 1.151374822 |
| GCST000050-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 2    | 0.084747 | 0.116587 | 0.467288 | 0.998683795 | -0.14376 | 0.313257 | 1.088442 | 0.866092416 | 1.367873703 |
| GCST002494-Bone mineral density (paediatric, total body less head)                                                                                                                    | Inverse variance weighted | 5    | 0.054054 | 0.074482 | 0.468002 | 0.998683795 | -0.09193 | 0.200039 | 1.055542 | 0.912168304 | 1.221450581 |
| GCST006983-Attention deficit hyperactivity disorder or cannabis use                                                                                                                   | Inverse variance weighted | 11   | -0.05237 | 0.072191 | 0.46819  | 0.998683795 | -0.19386 | 0.089125 | 0.948978 | 0.823770036 | 1.093217366 |
| GCST001762-Obesity-related traits                                                                                                                                                     | Inverse variance weighted | 6    | 0.090305 | 0.124583 | 0.468537 | 0.998683795 | -0.15388 | 0.334487 | 1.094508 | 0.85737763  | 1.397223958 |
| GCST001496-Non-albumin protein levels                                                                                                                                                 | Inverse variance weighted | 3    | -0.08347 | 0.115325 | 0.469201 | 0.998683795 | -0.30951 | 0.142567 | 0.919919 | 0.733808322 | 1.153230806 |
| GCST006186-Systolic blood pressure x smoking status (current vs non-current) interaction (1df test)                                                                                   | Inverse variance weighted | 2    | 0.003908 | 0.005404 | 0.469622 | 0.998683795 | -0.00668 | 0.0145   | 1.003915 | 0.993337839 | 1.01460553  |
| GCST001159-Restless legs syndrome                                                                                                                                                     | Inverse variance weighted | 6    | 0.014949 | 0.020793 | 0.472182 | 0.998683795 | -0.02581 | 0.055703 | 1.015061 | 0.974524707 | 1.057283459 |
| GCST002081-Migraine                                                                                                                                                                   | Inverse variance weighted | 5    | 0.084581 | 0.117651 | 0.472197 | 0.998683795 | -0.14602 | 0.315177 | 1.088261 | 0.864143911 | 1.370502206 |
| GCST000174-Height                                                                                                                                                                     | Inverse variance weighted | 12   | -0.05412 | 0.075286 | 0.472204 | 0.998683795 | -0.20168 | 0.093438 | 0.947316 | 0.817353444 | 1.097942129 |
| GCST000169-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 2    | -0.12394 | 0.173093 | 0.473965 | 0.998683795 | -0.4632  | 0.21532  | 0.883431 | 0.629264119 | 1.240258903 |
| GCST005651-Urinary metabolite concentrations in chronic kidney disease                                                                                                                | Inverse variance weighted | 4    | -0.02315 | 0.032401 | 0.474899 | 0.998683795 | -0.08666 | 0.040355 | 0.977114 | 0.916990506 | 1.04118005  |
| GCST003258-Ischemic stroke                                                                                                                                                            | Inverse variance weighted | 2    | 0.137003 | 0.192404 | 0.47643  | 0.998683795 | -0.24011 | 0.514116 | 1.146831 | 0.786541543 | 1.672158826 |
| GCST004576-Waist-to-hip ratio adjusted for body mass index                                                                                                                            | Inverse variance weighted | 40   | 0.055746 | 0.078497 | 0.477602 | 0.998683795 | -0.09811 | 0.209601 | 1.057329 | 0.906550144 | 1.233186116 |
| GCST002217-Sj?gren's syndrome                                                                                                                                                         | Inverse variance weighted | 2    | 0.053032 | 0.074736 | 0.47796  | 0.998683795 | -0.09345 | 0.199516 | 1.054464 | 0.910782267 | 1.220811301 |
| GCST000442-Aortic root size                                                                                                                                                           | Inverse variance weighted | 3    | -0.23605 | 0.332818 | 0.478163 | 0.998683795 | -0.88838 | 0.416269 | 0.789737 | 0.411322035 | 1.516293881 |
| GCST002461-Body mass index                                                                                                                                                            | Inverse variance weighted | 10   | 0.107611 | 0.151753 | 0.47825  | 0.998683795 | -0.18983 | 0.405048 | 1.113615 | 0.827103828 | 1.499374223 |
| GCST002012-Venous thromboembolism                                                                                                                                                     | Inverse variance weighted | 2    | -0.03761 | 0.053085 | 0.478626 | 0.998683795 | -0.14166 | 0.066435 | 0.963087 | 0.867917737 | 1.068691756 |
| GCST000428-Adiposity                                                                                                                                                                  | Inverse variance weighted | 2    | -0.3966  | 0.56218  | 0.480524 | 0.998683795 | -1.49847 | 0.705277 | 0.672606 | 0.223472333 | 2.024407219 |
| GCST007134-Total cholesterol levels                                                                                                                                                   | Inverse variance weighted | 8    | 0.331014 | 0.470513 | 0.481733 | 0.998683795 | -0.59119 | 1.25322  | 1.39238  | 0.5536674   | 3.501599933 |
| GCST001267-Melanoma                                                                                                                                                                   | Inverse variance weighted | 4    | 0.044682 | 0.063581 | 0.482205 | 0.998683795 | -0.07994 | 0.1693   | 1.045695 | 0.923175193 | 1.184475758 |
| GCST007293-Body fat distribution (arm fat ratio)                                                                                                                                      | Inverse variance weighted | 21   | 0.135671 | 0.193752 | 0.483782 | 0.998683795 | -0.24408 | 0.515425 | 1.145305 | 0.783422993 | 1.674350332 |
| GCST007098-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 12   | 0.020585 | 0.029436 | 0.484371 | 0.998683795 | -0.03711 | 0.07828  | 1.020798 | 0.963569498 | 1.081425119 |
| GCST000157-Celiac disease                                                                                                                                                             | Inverse variance weighted | 4    | 0.023615 | 0.03379  | 0.484626 | 0.998683795 | -0.04261 | 0.089844 | 1.023896 | 0.958281576 | 1.09400411  |
| GCST004607-Plateletcrit                                                                                                                                                               | Inverse variance weighted | 128  | -0.02613 | 0.037432 | 0.485219 | 0.998683795 | -0.09949 | 0.047242 | 0.974213 | 0.905297293 | 1.048375394 |
| GCST006700-Parental longevity (father's age at death)                                                                                                                                 | Inverse variance weighted | 2    | -17.9067 | 25.7031  | 0.486007 | 0.998683795 | -68.2848 | 32.47139 | 1.67E-08 | 2.20956E-30 | 1.26516E+14 |
| GCST003666-Metabolite levels (small molecules and protein measures)                                                                                                                   | Inverse variance weighted | 22   | -0.02356 | 0.033837 | 0.486201 | 0.998683795 | -0.08988 | 0.042757 | 0.976713 | 0.914038284 | 1.04368465  |
| GCST007707-Hypertension                                                                                                                                                               | Inverse variance weighted | 40   | 0.025039 | 0.036029 | 0.487077 | 0.998683795 | -0.04558 | 0.095656 | 1.025355 | 0.955445119 | 1.100380267 |
| GCST005896-Non-melanoma skin cancer                                                                                                                                                   | Inverse variance weighted | 23   | 0.021328 | 0.03069  | 0.487091 | 0.998683795 | -0.03882 | 0.08148  | 1.021557 | 0.961919416 | 1.084891752 |
| GCST000810-Lung adenocarcinoma                                                                                                                                                        | Inverse variance weighted | 2    | -0.0808  | 0.116689 | 0.488654 | 0.998683795 | -0.30951 | 0.147909 | 0.922377 | 0.733805528 | 1.159407107 |
| GCST007340-Depressive symptoms                                                                                                                                                        | Inverse variance weighted | 154  | -0.16058 | 0.232087 | 0.489001 | 0.998683795 | -0.61547 | 0.294309 | 0.851649 | 0.540386532 | 1.342199051 |
| GCST005273-Polycystic ovary syndrome                                                                                                                                                  | Inverse variance weighted | 2    | -0.02712 | 0.039209 | 0.489115 | 0.998683795 | -0.10397 | 0.049728 | 0.973243 | 0.90125164  | 1.05098505  |
| GCST004329-Mean corpuscular hemoglobin concentration                                                                                                                                  | Inverse variance weighted | 2    | 0.13997  | 0.202477 | 0.489385 | 0.998683795 | -0.25688 | 0.536824 | 1.150239 | 0.773457335 | 1.710566178 |
| GCST000499-Hemoglobin                                                                                                                                                                 | Inverse variance weighted | 5    | -0.08332 | 0.120674 | 0.48989  | 0.998683795 | -0.31984 | 0.153198 | 0.920053 | 0.726261895 | 1.16555534  |
| GCST000358-Folate pathway vitamin levels                                                                                                                                              | Inverse variance weighted | 2    | -0.00047 | 0.000677 | 0.489994 | 0.998683795 | -0.00179 | 0.00086  | 0.999533 | 0.998207345 | 1.000859943 |
| GCST004623-Neutrophil percentage of granulocytes                                                                                                                                      | Inverse variance weighted | 92   | 0.039342 | 0.056995 | 0.49002  | 0.998683795 | -0.07237 | 0.151052 | 1.040126 | 0.93018901  | 1.163056749 |
| GCST004171-Macular telangiectasia type 2                                                                                                                                              | Inverse variance weighted | 2    | 0.014837 | 0.021497 | 0.490076 | 0.998683795 | -0.0273  | 0.056972 | 1.014948 | 0.973071804 | 1.058625719 |
| GCST007350-Focal epilepsy (with hippocampal sclerosis)                                                                                                                                | Inverse variance weighted | 2    | -0.00259 | 0.00376  | 0.49058  | 0.998683795 | -0.00996 | 0.004777 | 0.997411 | 0.990088625 | 1.004788516 |
| GCST001810-Menopause (age at onset)                                                                                                                                                   | Inverse variance weighted | 2    | 0.030122 | 0.043917 | 0.492778 | 0.998683795 | -0.05595 | 0.116199 | 1.030581 | 0.945582297 | 1.123219416 |
| GCST001276-Liver enzyme levels (alkaline phosphatase)                                                                                                                                 | Inverse variance weighted | 9    | 0.001466 | 0.002137 | 0.492798 | 0.998683795 | -0.00272 | 0.005655 | 1.001467 | 0.997280489 | 1.00567104  |
| GCST003177-Childhood body mass index                                                                                                                                                  | Inverse variance weighted | 13   | -0.05774 | 0.084488 | 0.494381 | 0.998683795 | -0.22333 | 0.107861 | 0.943899 | 0.799848615 | 1.113893312 |
| GCST004207-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 10   | -0.10856 | 0.159052 | 0.494906 | 0.998683795 | -0.4203  | 0.203184 | 0.897128 | 0.656850859 | 1.225298345 |
| GCST000679-Rheumatoid arthritis                                                                                                                                                       | Inverse variance weighted | 3    | 0.024789 | 0.036367 | 0.495467 | 0.998683795 | -0.04649 | 0.09607  | 1.025099 | 0.954573486 | 1.100835666 |
| GCST001702-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 2    | -0.03466 | 0.05098  | 0.496613 | 0.998683795 | -0.13458 | 0.065263 | 0.965936 | 0.874084225 | 1.067439882 |
| GCST004696-Chronotype                                                                                                                                                                 | Inverse variance weighted | 3    | -0.22967 | 0.340595 | 0.500108 | 0.998683795 | -0.89724 | 0.437897 | 0.794796 | 0.4076948   | 1.54944487  |
| GCST000290-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 11   | -0.04416 | 0.065566 | 0.500593 | 0.998683795 | -0.17267 | 0.084347 | 0.956798 | 0.841413181 | 1.088006614 |
| GCST005891-Glomerular filtration rate in diabetes                                                                                                                                     | Inverse variance weighted | 2    | -0.01254 | 0.018633 | 0.500926 | 0.998683795 | -0.04906 | 0.02398  | 0.987538 | 0.952122962 | 1.024269779 |
| GCST002477-Alcohol dependence (age at onset)                                                                                                                                          | Inverse variance weighted | 3    | 0.028535 | 0.042468 | 0.501643 | 0.998683795 | -0.0547  | 0.111773 | 1.028946 | 0.946766111 | 1.118258634 |
| GCST007463-Cigarettes smoked per day (MTAG)                                                                                                                                           | Inverse variance weighted | 52   | -0.09789 | 0.145794 | 0.501944 | 0.998683795 | -0.38365 | 0.187866 | 0.906747 | 0.681371073 | 1.206671383 |
| GCST004278-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 35   | -0.01676 | 0.025009 | 0.502645 | 0.998683795 | -0.06578 | 0.032253 | 0.983376 | 0.936335729 | 1.032778599 |
| GCST002861-Breast cancer (survival)                                                                                                                                                   | Inverse variance weighted | 2    | 0.034058 | 0.050867 | 0.503145 | 0.998683795 | -0.06564 | 0.133757 | 1.034645 | 0.936466594 | 1.143115548 |
| GCST004234-HDL cholesterol levels                                                                                                                                                     | Inverse variance weighted | 8    | -0.06102 | 0.091165 | 0.503266 | 0.998683795 | -0.2397  | 0.117661 | 0.940803 | 0.786860233 | 1.124862493 |
| GCST000289-Triglycerides                                                                                                                                                              | Inverse variance weighted | 7    | 0.326676 | 0.488286 | 0.503478 | 0.998683795 | -0.63036 | 1.283717 | 1.386353 | 0.532398035 | 3.610031742 |
| GCST000488-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 2    | -0.07013 | 0.104902 | 0.503798 | 0.998683795 | -0.27574 | 0.135478 | 0.932273 | 0.759012277 | 1.145083968 |
| GCST006424-Severe diabetic retinopathy in type 2 diabetes                                                                                                                             | Inverse variance weighted | 2    | 0.019197 | 0.028759 | 0.504441 | 0.998683795 | -0.03717 | 0.075566 | 1.019383 | 0.963511532 | 1.078493878 |
| GCST002797-Pulmonary artery enlargement in chronic obstructive pulmonary disease                                                                                                      | Inverse variance weighted | 2    | -0.07684 | 0.115122 | 0.504462 | 0.998683795 | -0.30248 | 0.148797 | 0.926036 | 0.738981406 | 1.160437836 |
| GCST004422-Vascular endothelial growth factor levels                                                                                                                                  | Inverse variance weighted | 3    | 0.052779 | 0.079104 | 0.504638 | 0.998683795 | -0.10227 | 0.207824 | 1.054197 | 0.902789934 | 1.230996217 |
| GCST004508-Waist-to-hip ratio adjusted for BMI in non-smokers                                                                                                                         | Inverse variance weighted | 10   | -0.17115 | 0.256546 | 0.50469  | 0.998683795 | -0.67398 | 0.33168  | 0.842696 | 0.509676954 | 1.393307441 |
| GCST002233-Adiponectin levels                                                                                                                                                         | Inverse variance weighted | 3    | -0.07336 | 0.109997 | 0.504811 | 0.998683795 | -0.28896 | 0.142233 | 0.929265 | 0.749045876 | 1.15284477  |
| GCST000297-Bone mineral density (hip)                                                                                                                                                 | Inverse variance weighted | 3    | -0.06438 | 0.09669  | 0.505546 | 0.998683795 | -0.25389 | 0.125138 | 0.937653 | 0.775778784 | 1.133304315 |
| GCST008171-Platelet aggregation                                                                                                                                                       | Inverse variance weighted | 3    | -0.05741 | 0.086457 | 0.506654 | 0.998683795 | -0.22687 | 0.112044 | 0.944204 | 0.797024995 | 1.118561955 |
| GCST001140-Lung cancer                                                                                                                                                                | Inverse variance weighted | 4    | -0.04484 | 0.067549 | 0.506854 | 0.998683795 | -0.17723 | 0.087561 | 0.956155 | 0.837586292 | 1.091508449 |
| GCST003853-Hip minimal joint space width                                                                                                                                              | Inverse variance weighted | 4    | -0.07402 | 0.111668 | 0.507428 | 0.998683795 | -0.29289 | 0.14485  | 0.928654 | 0.746106502 | 1.155865992 |
| GCST007099-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 104  | -0.00439 | 0.006652 | 0.509096 | 0.998683795 | -0.01743 | 0.008646 | 0.995618 | 0.982720731 | 1.008683666 |
| GCST002223-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 39   | -0.06281 | 0.095139 | 0.509122 | 0.998683795 | -0.24928 | 0.123661 | 0.939121 | 0.779358504 | 1.13163255  |
| GCST004619-Reticulocyte fraction of red cells                                                                                                                                         | Inverse variance weighted | 99   | 0.038947 | 0.059151 | 0.510261 | 0.998683795 | -0.07699 | 0.154883 | 1.039715 | 0.925899796 | 1.167521452 |
| GCST001506-Intraocular pressure                                                                                                                                                       | Inverse variance weighted | 2    | -0.05703 | 0.086726 | 0.510813 | 0.998683795 | -0.22701 | 0.112954 | 0.944567 | 0.796911878 | 1.119580486 |
| GCST000589-White blood cell count                                                                                                                                                     | Inverse variance weighted | 4    | -0.07549 | 0.115028 | 0.511665 | 0.998683795 | -0.30094 | 0.149968 | 0.927292 | 0.740120529 | 1.161797407 |
| GCST001826-Lymphoma                                                                                                                                                                   | Inverse variance weighted | 2    | 0.114694 | 0.175188 | 0.512669 | 0.998683795 | -0.22868 | 0.458063 | 1.12153  | 0.795586567 | 1.581008183 |
| GCST007939-Medication use (antimigraine preparations)                                                                                                                                 | Inverse variance weighted | 10   | 0.029238 | 0.04469  | 0.512962 | 0.998683795 | -0.05835 | 0.11683  | 1.029669 | 0.943315295 | 1.123928216 |
| GCST007701-High density lipoprotein cholesterol levels                                                                                                                                | Inverse variance weighted | 7    | 0.001963 | 0.003001 | 0.513096 | 0.998683795 | -0.00392 | 0.007844 | 1.001965 | 0.996088707 | 1.007874991 |
| GCST004332-Red blood cell count                                                                                                                                                       | Inverse variance weighted | 3    | -0.17404 | 0.266723 | 0.514071 | 0.998683795 | -0.69682 | 0.348737 | 0.840263 | 0.498168714 | 1.417275944 |
| GCST007438-High density lipoprotein cholesterol levels                                                                                                                                | Inverse variance weighted | 6    | -2.34696 | 3.607184 | 0.515283 | 0.998683795 | -9.41704 | 4.723125 | 0.09566  | 8.13267E-05 | 112.5193356 |
| GCST002239-Symmetrical dimethylarginine levels                                                                                                                                        | Inverse variance weighted | 3    | 0.044987 | 0.069164 | 0.51541  | 0.998683795 | -0.09057 | 0.180548 | 1.046014 | 0.913406061 | 1.197874167 |
| GCST003720-Migraine                                                                                                                                                                   | Inverse variance weighted | 19   | -0.04606 | 0.070973 | 0.516337 | 0.998683795 | -0.18517 | 0.093045 | 0.954983 | 0.830964559 | 1.097511338 |
| GCST004713-Testicular germ cell tumor                                                                                                                                                 | Inverse variance weighted | 21   | 0.011436 | 0.017623 | 0.516387 | 0.998683795 | -0.0231  | 0.045976 | 1.011501 | 0.977160281 | 1.047049382 |
| GCST001688-Type 1 diabetes nephropathy                                                                                                                                                | Inverse variance weighted | 2    | 0.040063 | 0.061797 | 0.516785 | 0.998683795 | -0.08106 | 0.161184 | 1.040877 | 0.922140319 | 1.174901647 |
| GCST002047-Educational attainment                                                                                                                                                     | Inverse variance weighted | 2    | 0.095817 | 0.147987 | 0.517328 | 0.998683795 | -0.19424 | 0.385872 | 1.100558 | 0.823462338 | 1.470895685 |
| GCST001011-Oral cavity and pharyngeal cancer                                                                                                                                          | Inverse variance weighted | 3    | 0.076991 | 0.119019 | 0.517713 | 0.998683795 | -0.15629 | 0.310269 | 1.080032 | 0.855313347 | 1.363791847 |
| GCST000139-Triglycerides                                                                                                                                                              | Inverse variance weighted | 6    | -0.00054 | 0.000828 | 0.518095 | 0.998683795 | -0.00216 | 0.001088 | 0.999465 | 0.997843068 | 1.001088983 |
| GCST006867-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 92   | 0.021816 | 0.033851 | 0.51927  | 0.998683795 | -0.04453 | 0.088165 | 1.022056 | 0.956444525 | 1.092168219 |
| GCST004605-Mean corpuscular hemoglobin concentration                                                                                                                                  | Inverse variance weighted | 34   | -0.05308 | 0.08244  | 0.519628 | 0.998683795 | -0.21467 | 0.108498 | 0.9483   | 0.806810002 | 1.114602328 |
| GCST004074-Intraocular pressure                                                                                                                                                       | Inverse variance weighted | 8    | -0.02239 | 0.034785 | 0.51974  | 0.998683795 | -0.09057 | 0.045786 | 0.977856 | 0.91340914  | 1.046850264 |
| GCST002073-Chronic lymphocytic leukemia                                                                                                                                               | Inverse variance weighted | 5    | -0.02052 | 0.031897 | 0.519962 | 0.998683795 | -0.08304 | 0.041995 | 0.979687 | 0.92031365  | 1.042889714 |
| GCST000945-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 2    | 0.035892 | 0.055853 | 0.520474 | 0.998683795 | -0.07358 | 0.145363 | 1.036544 | 0.929062093 | 1.156459819 |
| GCST006947-Feeling fed-up                                                                                                                                                             | Inverse variance weighted | 30   | 0.000348 | 0.000541 | 0.520617 | 0.998683795 | -0.00071 | 0.001409 | 1.000348 | 0.999287048 | 1.001409641 |
| GCST002748-Epithelial ovarian cancer                                                                                                                                                  | Inverse variance weighted | 6    | -0.03546 | 0.055291 | 0.521314 | 0.998683795 | -0.14383 | 0.072911 | 0.965162 | 0.866034781 | 1.075635196 |
| GCST003128-Adolescent idiopathic scoliosis                                                                                                                                            | Inverse variance weighted | 2    | -0.0249  | 0.038855 | 0.521652 | 0.998683795 | -0.10105 | 0.051258 | 0.975409 | 0.903883459 | 1.052594219 |
| GCST006925-Knee osteoarthritis                                                                                                                                                        | Inverse variance weighted | 4    | 0.140116 | 0.218792 | 0.521907 | 0.998683795 | -0.28872 | 0.568948 | 1.150407 | 0.749225298 | 1.766407706 |
| GCST006045-Age at first birth                                                                                                                                                         | Inverse variance weighted | 5    | -0.06868 | 0.107359 | 0.52234  | 0.998683795 | -0.27911 | 0.141742 | 0.933623 | 0.756459824 | 1.152278855 |
| GCST002553-Pancreatic cancer                                                                                                                                                          | Inverse variance weighted | 5    | 0.033421 | 0.052298 | 0.522785 | 0.998683795 | -0.06908 | 0.135924 | 1.033986 | 0.933250179 | 1.145595168 |
| GCST003238-Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid)                                                                                                    | Inverse variance weighted | 3    | 0.013362 | 0.02094  | 0.523401 | 0.998683795 | -0.02768 | 0.054404 | 1.013452 | 0.972699384 | 1.055911265 |
| GCST007998-Intraocular pressure                                                                                                                                                       | Inverse variance weighted | 8    | 0.000761 | 0.001193 | 0.523413 | 0.998683795 | -0.00158 | 0.003099 | 1.000761 | 0.998424367 | 1.003104022 |
| GCST000796-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 2    | 0.057787 | 0.090727 | 0.524168 | 0.998683795 | -0.12004 | 0.235613 | 1.05949  | 0.886886585 | 1.2656841   |
| GCST004629-Neutrophil count                                                                                                                                                           | Inverse variance weighted | 65   | -0.05299 | 0.083246 | 0.524402 | 0.998683795 | -0.21616 | 0.11017  | 0.948387 | 0.805610172 | 1.116468232 |
| GCST002030-Primary tooth development (time to first tooth eruption)                                                                                                                   | Inverse variance weighted | 5    | 0.022886 | 0.036009 | 0.525067 | 0.998683795 | -0.04769 | 0.093463 | 1.023149 | 0.953427621 | 1.09796983  |
| GCST007094-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 104  | -0.00748 | 0.011782 | 0.5256   | 0.998683795 | -0.03057 | 0.015614 | 0.992549 | 0.96989164  | 1.01573665  |
| GCST003274-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 3    | -0.01455 | 0.023022 | 0.52727  | 0.998683795 | -0.05968 | 0.03057  | 0.985551 | 0.942067512 | 1.031041744 |
| GCST004292-Glomerular filtration rate (creatinine)                                                                                                                                    | Inverse variance weighted | 35   | 0.226967 | 0.359029 | 0.527277 | 0.998683795 | -0.47673 | 0.930664 | 1.254788 | 0.620809498 | 2.536193789 |
| GCST002568-Esophageal squamous cell carcinoma                                                                                                                                         | Inverse variance weighted | 4    | 0.023844 | 0.037755 | 0.527689 | 0.998683795 | -0.05016 | 0.097844 | 1.02413  | 0.951080711 | 1.102790707 |
| GCST000599-Soluble levels of adhesion molecules                                                                                                                                       | Inverse variance weighted | 3    | 0.000566 | 0.000899 | 0.528817 | 0.998683795 | -0.0012  | 0.002327 | 1.000566 | 0.998805538 | 1.00232966  |
| GCST002390-Glycated hemoglobin levels                                                                                                                                                 | Inverse variance weighted | 8    | -0.05446 | 0.086473 | 0.528826 | 0.998683795 | -0.22395 | 0.115026 | 0.946996 | 0.799357671 | 1.121902637 |
| GCST005327-Neuroticism                                                                                                                                                                | Inverse variance weighted | 2    | -0.33769 | 0.536485 | 0.529052 | 0.998683795 | -1.3892  | 0.713818 | 0.713415 | 0.249273891 | 2.04177154  |
| GCST007337-Life satisfaction                                                                                                                                                          | Inverse variance weighted | 92   | 0.151137 | 0.24082  | 0.530269 | 0.998683795 | -0.32087 | 0.623145 | 1.163156 | 0.725517674 | 1.864782814 |
| GCST000673-Cleft lip                                                                                                                                                                  | Inverse variance weighted | 2    | -0.01942 | 0.031002 | 0.530982 | 0.998683795 | -0.08019 | 0.041341 | 0.980764 | 0.922943417 | 1.042207586 |
| GCST001787-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 2    | 0.149981 | 0.240054 | 0.532115 | 0.998683795 | -0.32052 | 0.620487 | 1.161812 | 0.725768325 | 1.859833072 |
| GCST003301-Triglycerides                                                                                                                                                              | Inverse variance weighted | 2    | 0.084797 | 0.13577  | 0.532257 | 0.998683795 | -0.18131 | 0.350906 | 1.088496 | 0.834175288 | 1.420353158 |
| GCST000025-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 5    | 0.023961 | 0.038431 | 0.532965 | 0.998683795 | -0.05136 | 0.099287 | 1.024251 | 0.949932874 | 1.104382992 |
| GCST002843-Sitting height ratio                                                                                                                                                       | Inverse variance weighted | 5    | -0.06285 | 0.101257 | 0.534775 | 0.998683795 | -0.26132 | 0.13561  | 0.939081 | 0.770036311 | 1.145235366 |
| GCST007388-Insomnia symptoms (never/rarely vs. usually)                                                                                                                               | Inverse variance weighted | 27   | 0.073453 | 0.118716 | 0.536093 | 0.998683795 | -0.15923 | 0.306136 | 1.076218 | 0.852800482 | 1.358167458 |
| GCST004231-Total cholesterol levels                                                                                                                                                   | Inverse variance weighted | 11   | 0.089514 | 0.144787 | 0.536413 | 0.998683795 | -0.19427 | 0.373296 | 1.093642 | 0.823437119 | 1.45251371  |
| GCST004559-Body mass index in physically active individuals                                                                                                                           | Inverse variance weighted | 37   | -0.06894 | 0.111594 | 0.536712 | 0.998683795 | -0.28767 | 0.149783 | 0.933381 | 0.750011296 | 1.161581739 |
| GCST007934-Medication use (anti-inflammatory and antirheumatic products, non-steroids)                                                                                                | Inverse variance weighted | 3    | 0.124134 | 0.201128 | 0.537112 | 0.998683795 | -0.27008 | 0.518345 | 1.132167 | 0.763320338 | 1.679245623 |
| GCST002378-Thyroid peroxidase antibody positivity                                                                                                                                     | Inverse variance weighted | 3    | -0.04123 | 0.066953 | 0.538068 | 0.998683795 | -0.17245 | 0.090003 | 0.959613 | 0.841597179 | 1.094177279 |
| GCST007856-Colorectal cancer or advanced adenoma                                                                                                                                      | Inverse variance weighted | 65   | 0.018641 | 0.030353 | 0.539116 | 0.998683795 | -0.04085 | 0.078133 | 1.018816 | 0.959972508 | 1.081266709 |
| GCST000024-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 4    | 0.036099 | 0.058865 | 0.539706 | 0.998683795 | -0.07928 | 0.151475 | 1.036759 | 0.923784952 | 1.16354895  |
| GCST004413-Spontaneous dizygotic twinning                                                                                                                                             | Inverse variance weighted | 2    | -0.06475 | 0.105603 | 0.53976  | 0.998683795 | -0.27174 | 0.142229 | 0.937299 | 0.762055734 | 1.152840386 |
| GCST004549-Endometriosis                                                                                                                                                              | Inverse variance weighted | 7    | -0.04316 | 0.070477 | 0.540256 | 0.998683795 | -0.1813  | 0.094972 | 0.957757 | 0.834188615 | 1.099628429 |
| GCST000035-Breast cancer                                                                                                                                                              | Inverse variance weighted | 5    | -0.03014 | 0.049288 | 0.540898 | 0.998683795 | -0.12674 | 0.066467 | 0.970312 | 0.880961102 | 1.068725702 |
| GCST001069-Thyroid volume                                                                                                                                                             | Inverse variance weighted | 5    | 0.017017 | 0.02785  | 0.541197 | 0.998683795 | -0.03757 | 0.071603 | 1.017162 | 0.963127054 | 1.074229027 |
| GCST006896-Free thyroxine concentration                                                                                                                                               | Inverse variance weighted | 9    | -0.09796 | 0.160403 | 0.541405 | 0.998683795 | -0.41235 | 0.216434 | 0.906688 | 0.662094536 | 1.241640654 |
| GCST003790-Glomerular filtration rate                                                                                                                                                 | Inverse variance weighted | 11   | 0.003126 | 0.005119 | 0.541429 | 0.998683795 | -0.00691 | 0.013158 | 1.003131 | 0.993117094 | 1.013244977 |
| GCST002444-Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid)                                                                                             | Inverse variance weighted | 3    | -0.02201 | 0.036126 | 0.542322 | 0.998683795 | -0.09282 | 0.048795 | 0.978229 | 0.91135944  | 1.050004867 |
| GCST007710-Anxiety/tension (special factor of neuroticism)                                                                                                                            | Inverse variance weighted | 13   | -0.30612 | 0.5036   | 0.543284 | 0.998683795 | -1.29317 | 0.68094  | 0.736301 | 0.274399065 | 1.975734508 |
| GCST004631-Basophil percentage of white cells                                                                                                                                         | Inverse variance weighted | 26   | -0.06268 | 0.10319  | 0.543573 | 0.998683795 | -0.26493 | 0.139573 | 0.939244 | 0.767258172 | 1.149782522 |
| GCST005287-Intrinsic epigenetic age acceleration                                                                                                                                      | Inverse variance weighted | 5    | -0.01213 | 0.019987 | 0.543803 | 0.998683795 | -0.05131 | 0.027041 | 0.98794  | 0.949986003 | 1.027409888 |
| GCST003842-Breast cancer (estrogen-receptor negative)                                                                                                                                 | Inverse variance weighted | 7    | -0.03518 | 0.057982 | 0.544078 | 0.998683795 | -0.14882 | 0.07847  | 0.965436 | 0.861723515 | 1.081630774 |
| GCST001436-Metabolic syndrome                                                                                                                                                         | Inverse variance weighted | 12   | 0.321715 | 0.530817 | 0.544466 | 0.998683795 | -0.71869 | 1.362117 | 1.379491 | 0.487391488 | 3.904450205 |
| GCST003619-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 8    | -0.49103 | 0.81246  | 0.545596 | 0.998683795 | -2.08345 | 1.101392 | 0.611996 | 0.124499935 | 3.008351247 |
| GCST004867-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 10   | 0.022827 | 0.037804 | 0.545954 | 0.998683795 | -0.05127 | 0.096923 | 1.02309  | 0.950023438 | 1.101776002 |
| GCST000175-Height                                                                                                                                                                     | Inverse variance weighted | 17   | -0.00041 | 0.000688 | 0.547318 | 0.998683795 | -0.00176 | 0.000935 | 0.999586 | 0.998238112 | 1.000935386 |
| GCST007513-Prostate-specific antigen levels                                                                                                                                           | Inverse variance weighted | 4    | -0.14708 | 0.244597 | 0.547621 | 0.998683795 | -0.62649 | 0.332326 | 0.863222 | 0.534462927 | 1.394207839 |
| GCST002087-Homocysteine levels                                                                                                                                                        | Inverse variance weighted | 11   | 0.040031 | 0.06662  | 0.547922 | 0.998683795 | -0.09055 | 0.170606 | 1.040843 | 0.913433071 | 1.186023779 |
| GCST003520-Breast cancer                                                                                                                                                              | Inverse variance weighted | 4    | -0.02991 | 0.04991  | 0.548945 | 0.998683795 | -0.12774 | 0.06791  | 0.97053  | 0.880085197 | 1.070269341 |
| GCST005187-Matrix metalloproteinase-8 levels                                                                                                                                          | Inverse variance weighted | 2    | 0.047788 | 0.079808 | 0.549309 | 0.998683795 | -0.10863 | 0.204212 | 1.048949 | 0.897058129 | 1.22655759  |
| GCST007442-Low density lipoprotein cholesterol levels                                                                                                                                 | Inverse variance weighted | 3    | -0.23945 | 0.401156 | 0.550579 | 0.998683795 | -1.02571 | 0.546819 | 0.787063 | 0.358540951 | 1.72774778  |
| GCST002965-Glycerophospholipid levels                                                                                                                                                 | Inverse variance weighted | 15   | 0.034269 | 0.057494 | 0.551142 | 0.998683795 | -0.07842 | 0.146957 | 1.034863 | 0.924577285 | 1.158304016 |
| GCST001235-Blood pressure                                                                                                                                                             | Inverse variance weighted | 7    | -0.0118  | 0.019795 | 0.551152 | 0.998683795 | -0.0506  | 0.026999 | 0.988271 | 0.950662584 | 1.027367156 |
| GCST008154-Trunk fat mass                                                                                                                                                             | Inverse variance weighted | 2    | 0.075326 | 0.126888 | 0.552753 | 0.998683795 | -0.17338 | 0.324027 | 1.078236 | 0.840822002 | 1.38268503  |
| GCST000190-Black vs. blond hair color                                                                                                                                                 | Inverse variance weighted | 4    | -0.02076 | 0.035056 | 0.553802 | 0.998683795 | -0.08947 | 0.047954 | 0.979458 | 0.914419889 | 1.049122453 |
| GCST006627-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 69   | 0.01136  | 0.019226 | 0.554607 | 0.998683795 | -0.02632 | 0.049044 | 1.011425 | 0.974020188 | 1.050266295 |
| GCST002756-Subcortical brain region volumes                                                                                                                                           | Inverse variance weighted | 3    | 0.000359 | 0.000609 | 0.555118 | 0.998683795 | -0.00083 | 0.001552 | 1.000359 | 0.999166474 | 1.001553494 |
| GCST007128-Blood protein levels                                                                                                                                                       | Inverse variance weighted | 7    | 0.044417 | 0.075338 | 0.55548  | 0.998683795 | -0.10325 | 0.192079 | 1.045418 | 0.901905722 | 1.211765999 |
| GCST002227-Body mass index                                                                                                                                                            | Inverse variance weighted | 2    | -0.14267 | 0.242147 | 0.55573  | 0.998683795 | -0.61728 | 0.331936 | 0.867038 | 0.53940953  | 1.393664047 |
| GCST000178-C-reactive protein                                                                                                                                                         | Inverse variance weighted | 3    | -0.03798 | 0.064546 | 0.55629  | 0.998683795 | -0.16449 | 0.088534 | 0.962735 | 0.848328404 | 1.092571675 |
| GCST005308-Nonalcoholic fatty liver disease                                                                                                                                           | Inverse variance weighted | 5    | -0.01235 | 0.021042 | 0.557191 | 0.998683795 | -0.05359 | 0.02889  | 0.987724 | 0.947816611 | 1.02931157  |
| GCST006096-Age spots                                                                                                                                                                  | Inverse variance weighted | 2    | 0.057265 | 0.097621 | 0.557468 | 0.998683795 | -0.13407 | 0.248602 | 1.058936 | 0.874527017 | 1.282231915 |
| GCST001709-Atopic dermatitis                                                                                                                                                          | Inverse variance weighted | 7    | 0.018408 | 0.031409 | 0.557823 | 0.998683795 | -0.04315 | 0.079969 | 1.018578 | 0.957764833 | 1.083253348 |
| GCST005796-Lumbar spine bone mineral density                                                                                                                                          | Inverse variance weighted | 17   | 0.049195 | 0.084009 | 0.558147 | 0.998683795 | -0.11546 | 0.213853 | 1.050425 | 0.89095441  | 1.238439981 |
| GCST002145-Infantile hypertrophic pyloric stenosis                                                                                                                                    | Inverse variance weighted | 3    | -0.02335 | 0.040126 | 0.560697 | 0.998683795 | -0.10199 | 0.055301 | 0.976925 | 0.903036709 | 1.056858866 |
| GCST001027-Uterine fibroids                                                                                                                                                           | Inverse variance weighted | 3    | -0.03891 | 0.066941 | 0.561076 | 0.998683795 | -0.17011 | 0.092296 | 0.961838 | 0.8435683   | 1.096689167 |
| GCST004440-Interferon gamma-induced protein 10 levels                                                                                                                                 | Inverse variance weighted | 2    | -0.07544 | 0.129793 | 0.561077 | 0.998683795 | -0.32983 | 0.178952 | 0.927334 | 0.719042793 | 1.195963772 |
| GCST006897-Hyperthyroidism                                                                                                                                                            | Inverse variance weighted | 6    | 0.023523 | 0.040514 | 0.561498 | 0.998683795 | -0.05588 | 0.102931 | 1.023802 | 0.945648171 | 1.108415245 |
| GCST006412-Intraocular pressure                                                                                                                                                       | Inverse variance weighted | 78   | 0.011534 | 0.019915 | 0.562485 | 0.998683795 | -0.0275  | 0.050567 | 1.011601 | 0.972875037 | 1.051867823 |
| GCST000232-Rheumatoid arthritis                                                                                                                                                       | Inverse variance weighted | 2    | 0.03217  | 0.055799 | 0.564254 | 0.998683795 | -0.0772  | 0.141535 | 1.032693 | 0.925708849 | 1.15204102  |
| GCST005195-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 93   | -0.0317  | 0.055008 | 0.564433 | 0.998683795 | -0.13952 | 0.076117 | 0.968798 | 0.86977906  | 1.079088523 |
| GCST005666-Fractional excretion of metabolites in chronic kidney disease                                                                                                              | Inverse variance weighted | 2    | -0.03029 | 0.052808 | 0.566222 | 0.998683795 | -0.1338  | 0.073212 | 0.970162 | 0.874768062 | 1.075958841 |
| GCST000965-C-reactive protein levels                                                                                                                                                  | Inverse variance weighted | 14   | 0.041588 | 0.072715 | 0.567371 | 0.998683795 | -0.10093 | 0.184108 | 1.042464 | 0.903993474 | 1.202145846 |
| GCST001230-Triglycerides                                                                                                                                                              | Inverse variance weighted | 4    | 0.108196 | 0.189183 | 0.56738  | 0.998683795 | -0.2626  | 0.478995 | 1.114267 | 0.769047543 | 1.614451623 |
| GCST001745-Sagittal craniosynostosis                                                                                                                                                  | Inverse variance weighted | 2    | 0.005241 | 0.009178 | 0.567997 | 0.998683795 | -0.01275 | 0.023229 | 1.005254 | 0.98733294  | 1.02350104  |
| GCST000662-Vitiligo                                                                                                                                                                   | Inverse variance weighted | 5    | 0.01953  | 0.034281 | 0.568877 | 0.998683795 | -0.04766 | 0.08672  | 1.019722 | 0.953457859 | 1.090591013 |
| GCST003144-Polycystic ovary syndrome                                                                                                                                                  | Inverse variance weighted | 3    | -0.04746 | 0.083368 | 0.56919  | 0.998683795 | -0.21086 | 0.115945 | 0.953651 | 0.809888308 | 1.122934066 |
| GCST000539-Type 1 diabetes                                                                                                                                                            | Inverse variance weighted | 2    | 0.083081 | 0.145997 | 0.569317 | 0.998683795 | -0.20307 | 0.369236 | 1.08663  | 0.816218062 | 1.446628391 |
| GCST008163-Height                                                                                                                                                                     | Inverse variance weighted | 73   | -0.02883 | 0.050989 | 0.571743 | 0.998683795 | -0.12877 | 0.071105 | 0.971578 | 0.879174365 | 1.07369379  |
| GCST001735-PR interval                                                                                                                                                                | Inverse variance weighted | 5    | 0.001326 | 0.002346 | 0.571841 | 0.998683795 | -0.00327 | 0.005924 | 1.001327 | 0.996733734 | 1.005941574 |
| GCST005208-B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio                                                                                              | Inverse variance weighted | 2    | -0.04274 | 0.075961 | 0.573663 | 0.998683795 | -0.19162 | 0.106143 | 0.95816  | 0.825616591 | 1.111981291 |
| GCST002680-Iron status biomarkers (transferrin saturation)                                                                                                                            | Inverse variance weighted | 3    | -0.0378  | 0.067191 | 0.57376  | 0.998683795 | -0.16949 | 0.093897 | 0.962909 | 0.844095361 | 1.098446954 |
| GCST002782-Waist-to-hip ratio adjusted for body mass index                                                                                                                            | Inverse variance weighted | 45   | 0.056825 | 0.10115  | 0.574259 | 0.998683795 | -0.14143 | 0.255079 | 1.058471 | 0.868117029 | 1.290563325 |
| GCST000504-Mean corpuscular hemoglobin                                                                                                                                                | Inverse variance weighted | 3    | -0.57244 | 1.01903  | 0.574284 | 0.998683795 | -2.56974 | 1.424855 | 0.564145 | 0.076555257 | 4.157254505 |
| GCST002996-Folding of antihelix                                                                                                                                                       | Inverse variance weighted | 2    | -0.17009 | 0.302963 | 0.574505 | 0.998683795 | -0.7639  | 0.423714 | 0.843587 | 0.465846601 | 1.527625365 |
| GCST003155-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 33   | 0.011687 | 0.020829 | 0.574716 | 0.998683795 | -0.02914 | 0.052512 | 1.011756 | 0.971283566 | 1.05391473  |
| GCST003854-Gut microbiota (functional units)                                                                                                                                          | Inverse variance weighted | 17   | -0.00061 | 0.001094 | 0.576519 | 0.998683795 | -0.00276 | 0.001533 | 0.999389 | 0.997248212 | 1.001534649 |
| GCST000971-PR interval                                                                                                                                                                | Inverse variance weighted | 5    | 0.001154 | 0.002072 | 0.577589 | 0.998683795 | -0.00291 | 0.005215 | 1.001155 | 0.997096858 | 1.005228955 |
| GCST000363-QT interval                                                                                                                                                                | Inverse variance weighted | 10   | -0.00218 | 0.003908 | 0.577841 | 0.998683795 | -0.00984 | 0.005485 | 0.997827 | 0.990212439 | 1.005500419 |
| GCST000587-Mean corpuscular hemoglobin                                                                                                                                                | Inverse variance weighted | 9    | -0.04068 | 0.073194 | 0.578339 | 0.998683795 | -0.18414 | 0.102778 | 0.960134 | 0.831816926 | 1.108245781 |
| GCST000919-Serum prostate-specific antigen levels                                                                                                                                     | Inverse variance weighted | 6    | -0.00034 | 0.000622 | 0.579812 | 0.998683795 | -0.00156 | 0.000875 | 0.999656 | 0.998437224 | 1.000875409 |
| GCST002221-Cholesterol, total                                                                                                                                                         | Inverse variance weighted | 48   | 0.015283 | 0.027699 | 0.581115 | 0.998683795 | -0.03901 | 0.069573 | 1.0154   | 0.961744067 | 1.072050386 |
| GCST002555-Monocyte count                                                                                                                                                             | Inverse variance weighted | 3    | -0.00426 | 0.007727 | 0.581186 | 0.998683795 | -0.01941 | 0.010882 | 0.995746 | 0.980779251 | 1.010941914 |
| GCST006048-Rheumatoid arthritis (ACPA-positive)                                                                                                                                       | Inverse variance weighted | 34   | -0.01373 | 0.024918 | 0.581544 | 0.998683795 | -0.06257 | 0.035106 | 0.986361 | 0.939344911 | 1.035729805 |
| GCST004030-Primary sclerosing cholangitis                                                                                                                                             | Inverse variance weighted | 15   | -0.01719 | 0.031219 | 0.581812 | 0.998683795 | -0.07838 | 0.043995 | 0.982954 | 0.924611107 | 1.044977418 |
| GCST007983-Morningness                                                                                                                                                                | Inverse variance weighted | 165  | 0.054368 | 0.099117 | 0.583335 | 0.998683795 | -0.1399  | 0.248637 | 1.055873 | 0.869443735 | 1.282276596 |
| GCST002547-Epilepsy                                                                                                                                                                   | Inverse variance weighted | 2    | -0.05546 | 0.101597 | 0.58515  | 0.998683795 | -0.25459 | 0.14367  | 0.94605  | 0.775235028 | 1.154503399 |
| GCST002373-Thyroid peroxidase antibody levels                                                                                                                                         | Inverse variance weighted | 2    | -0.34188 | 0.627055 | 0.5856   | 0.998683795 | -1.57091 | 0.887143 | 0.71043  | 0.207855672 | 2.428181662 |
| GCST001968-Interstitial lung disease                                                                                                                                                  | Inverse variance weighted | 7    | -0.02509 | 0.046076 | 0.586023 | 0.998683795 | -0.1154  | 0.065216 | 0.975219 | 0.891007449 | 1.067389231 |
| GCST003045-Ulcerative colitis                                                                                                                                                         | Inverse variance weighted | 30   | 0.019967 | 0.036701 | 0.586405 | 0.998683795 | -0.05197 | 0.091901 | 1.020168 | 0.949360673 | 1.096256237 |
| GCST004948-Breast cancer                                                                                                                                                              | Inverse variance weighted | 2    | 0.076512 | 0.140851 | 0.586986 | 0.998683795 | -0.19956 | 0.35258  | 1.079515 | 0.819093831 | 1.422733541 |
| GCST007443-Nasal polyps                                                                                                                                                               | Inverse variance weighted | 5    | -0.02163 | 0.039818 | 0.587011 | 0.998683795 | -0.09967 | 0.056415 | 0.978604 | 0.905135366 | 1.058036635 |
| GCST008157-Body fat mass                                                                                                                                                              | Inverse variance weighted | 2    | -0.17483 | 0.322273 | 0.587483 | 0.998683795 | -0.80648 | 0.456826 | 0.839601 | 0.446425091 | 1.579053621 |
| GCST004643-1,5-anhydroglucitol levels                                                                                                                                                 | Inverse variance weighted | 5    | -0.00043 | 0.000801 | 0.587944 | 0.998683795 | -0.002   | 0.001136 | 0.999566 | 0.997998405 | 1.001136407 |
| GCST002677-Iron status biomarkers (ferritin levels)                                                                                                                                   | Inverse variance weighted | 2    | -0.07341 | 0.136014 | 0.589409 | 0.998683795 | -0.33999 | 0.193182 | 0.929223 | 0.711774374 | 1.213103956 |
| GCST006066-Glaucoma (primary open-angle)                                                                                                                                              | Inverse variance weighted | 4    | 0.039589 | 0.07357  | 0.590497 | 0.998683795 | -0.10461 | 0.183786 | 1.040383 | 0.90067777  | 1.201758629 |
| GCST004733-Heart rate variability traits (RMSSD)                                                                                                                                      | Inverse variance weighted | 10   | 0.067925 | 0.126449 | 0.591148 | 0.998683795 | -0.17991 | 0.315764 | 1.070285 | 0.835341714 | 1.371306503 |
| GCST007842-Glioma                                                                                                                                                                     | Inverse variance weighted | 2    | -0.04688 | 0.087297 | 0.591266 | 0.998683795 | -0.21798 | 0.124224 | 0.954203 | 0.804140601 | 1.132269028 |
| GCST002391-Plasma homocysteine levels (post-methionine load test)                                                                                                                     | Inverse variance weighted | 4    | -0.01542 | 0.028718 | 0.591334 | 0.998683795 | -0.07171 | 0.040868 | 0.984699 | 0.930804437 | 1.041715051 |
| GCST000701-Testicular germ cell cancer                                                                                                                                                | Inverse variance weighted | 2    | 0.060133 | 0.112072 | 0.591571 | 0.998683795 | -0.15953 | 0.279794 | 1.061978 | 0.852546764 | 1.322857193 |
| GCST003119-Urinary metabolites                                                                                                                                                        | Inverse variance weighted | 8    | -0.00719 | 0.013414 | 0.591985 | 0.998683795 | -0.03348 | 0.019102 | 0.992836 | 0.96707363  | 1.019285566 |
| GCST004697-Ease of getting up in the morning                                                                                                                                          | Inverse variance weighted | 2    | 0.24603  | 0.460378 | 0.593059 | 0.998683795 | -0.65631 | 1.14837  | 1.278937 | 0.51876167  | 3.153049141 |
| GCST001320-Acute lymphoblastic leukemia (childhood)                                                                                                                                   | Inverse variance weighted | 5    | -0.01751 | 0.032785 | 0.593387 | 0.998683795 | -0.08176 | 0.046754 | 0.982647 | 0.921488819 | 1.04786438  |
| GCST005650-Serum metabolite ratios in chronic kidney disease                                                                                                                          | Inverse variance weighted | 32   | -0.00407 | 0.007649 | 0.594585 | 0.998683795 | -0.01906 | 0.010921 | 0.995937 | 0.981117857 | 1.01098097  |
| GCST000755-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 26   | -0.00242 | 0.004576 | 0.596538 | 0.998683795 | -0.01139 | 0.006546 | 0.997581 | 0.988673592 | 1.006567741 |
| GCST001302-White blood cell count                                                                                                                                                     | Inverse variance weighted | 3    | -0.00659 | 0.012449 | 0.596547 | 0.998683795 | -0.03099 | 0.01781  | 0.993432 | 0.969485128 | 1.017969393 |
| GCST007458-Age of smoking initiation                                                                                                                                                  | Inverse variance weighted | 5    | -0.25044 | 0.473381 | 0.596777 | 0.998683795 | -1.17826 | 0.677389 | 0.77846  | 0.307812575 | 1.968730567 |
| GCST000531-Inflammatory bowel disease (early onset)                                                                                                                                   | Inverse variance weighted | 2    | 0.041229 | 0.077942 | 0.596823 | 0.998683795 | -0.11154 | 0.193995 | 1.042091 | 0.894458825 | 1.214089716 |
| GCST000248-Liver enzyme levels                                                                                                                                                        | Inverse variance weighted | 7    | -0.12176 | 0.230804 | 0.597811 | 0.998683795 | -0.57414 | 0.330615 | 0.88536  | 0.563190753 | 1.391823552 |
| GCST000037-Breast cancer                                                                                                                                                              | Inverse variance weighted | 2    | -0.03152 | 0.059758 | 0.597894 | 0.998683795 | -0.14864 | 0.085608 | 0.968973 | 0.861875786 | 1.089378709 |
| GCST005349-Total body bone mineral density (age over 60)                                                                                                                              | Inverse variance weighted | 8    | -0.04833 | 0.091643 | 0.597971 | 0.998683795 | -0.22794 | 0.131295 | 0.952824 | 0.796168071 | 1.140303709 |
| GCST007552-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 20   | 0.024708 | 0.046858 | 0.597987 | 0.998683795 | -0.06713 | 0.116549 | 1.025016 | 0.935070511 | 1.123613028 |
| GCST005586-Breast milk fatty acid composition (maternal genotype effect)                                                                                                              | Inverse variance weighted | 4    | -0.00294 | 0.005569 | 0.598046 | 0.998683795 | -0.01385 | 0.007979 | 0.997068 | 0.986244767 | 1.008010782 |
| GCST002894-Body mass index                                                                                                                                                            | Inverse variance weighted | 2    | 0.51353  | 0.976139 | 0.598831 | 0.998683795 | -1.3997  | 2.426762 | 1.67118  | 0.246670499 | 11.322156   |
| GCST003525-Endometrial endometrioid carcinoma                                                                                                                                         | Inverse variance weighted | 3    | 0.035989 | 0.068609 | 0.599901 | 0.998683795 | -0.09849 | 0.170463 | 1.036644 | 0.90620867  | 1.185853416 |
| GCST001904-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 3    | 0.029917 | 0.057118 | 0.600432 | 0.998683795 | -0.08203 | 0.141868 | 1.030369 | 0.921240965 | 1.152424358 |
| GCST005580-Intraocular pressure                                                                                                                                                       | Inverse variance weighted | 189  | 0.00664  | 0.012679 | 0.60051  | 0.998683795 | -0.01821 | 0.03149  | 1.006662 | 0.981953534 | 1.031991522 |
| GCST006247-Pediatric areal bone mineral density (radius vs spine & hip discordant skeletal phenotype)                                                                                 | Inverse variance weighted | 2    | -0.01951 | 0.037297 | 0.600869 | 0.998683795 | -0.09261 | 0.05359  | 0.980677 | 0.911544804 | 1.055052326 |
| GCST002881-ADAMTS13 activity                                                                                                                                                          | Inverse variance weighted | 2    | 0.001591 | 0.003042 | 0.600915 | 0.998683795 | -0.00437 | 0.007554 | 1.001592 | 0.995638466 | 1.007582104 |
| GCST002943-IgA nephropathy                                                                                                                                                            | Inverse variance weighted | 6    | -0.03    | 0.0581   | 0.605655 | 0.998683795 | -0.14387 | 0.08388  | 0.970449 | 0.865998486 | 1.087498077 |
| GCST003216-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 2    | 0.002652 | 0.005137 | 0.605673 | 0.998683795 | -0.00742 | 0.01272  | 1.002655 | 0.99261108  | 1.012801556 |
| GCST001606-Renal function-related traits (sCR)                                                                                                                                        | Inverse variance weighted | 5    | -0.89588 | 1.735854 | 0.605781 | 0.998683795 | -4.29816 | 2.50639  | 0.408246 | 0.013593572 | 12.26058478 |
| GCST000424-Multiple sclerosis                                                                                                                                                         | Inverse variance weighted | 3    | 0.034094 | 0.066093 | 0.605962 | 0.998683795 | -0.09545 | 0.163637 | 1.034682 | 0.908964912 | 1.177786138 |
| GCST004710-Renal cell carcinoma                                                                                                                                                       | Inverse variance weighted | 5    | -0.04754 | 0.092239 | 0.606248 | 0.998683795 | -0.22833 | 0.133245 | 0.953569 | 0.79586022  | 1.142530023 |
| GCST006227-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 6    | 0.017038 | 0.033146 | 0.607244 | 0.998683795 | -0.04793 | 0.082004 | 1.017184 | 0.953201476 | 1.085460223 |
| GCST007988-Insomnia                                                                                                                                                                   | Inverse variance weighted | 189  | -0.05456 | 0.106345 | 0.607911 | 0.998683795 | -0.263   | 0.153875 | 0.946901 | 0.768744561 | 1.16634476  |
| GCST005003-Mumps                                                                                                                                                                      | Inverse variance weighted | 2    | -0.13925 | 0.27147  | 0.607976 | 0.998683795 | -0.67134 | 0.392826 | 0.870007 | 0.51102581  | 1.481161305 |
| GCST005581-Primary biliary cirrhosis                                                                                                                                                  | Inverse variance weighted | 17   | -0.00835 | 0.016284 | 0.608062 | 0.998683795 | -0.04027 | 0.023566 | 0.991684 | 0.960531603 | 1.023845771 |
| GCST002468-Triglycerides                                                                                                                                                              | Inverse variance weighted | 2    | 0.037341 | 0.073025 | 0.609112 | 0.998683795 | -0.10579 | 0.18047  | 1.038047 | 0.899614842 | 1.197780224 |
| GCST007941-Medication use (adrenergics, inhalants)                                                                                                                                    | Inverse variance weighted | 38   | -0.0242  | 0.047543 | 0.610743 | 0.998683795 | -0.11738 | 0.068984 | 0.976091 | 0.889243996 | 1.071418952 |
| GCST000601-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 2    | 0.019974 | 0.03939  | 0.612097 | 0.998683795 | -0.05723 | 0.097178 | 1.020175 | 0.944376554 | 1.10205665  |
| GCST001607-Renal function-related traits (eGRFcrea)                                                                                                                                   | Inverse variance weighted | 5    | 0.79256  | 1.564685 | 0.612485 | 0.998683795 | -2.27422 | 3.859342 | 2.209044 | 0.102876841 | 47.43414602 |
| GCST001852-Metabolite levels                                                                                                                                                          | Inverse variance weighted | 3    | -0.01289 | 0.025462 | 0.612718 | 0.998683795 | -0.06279 | 0.037017 | 0.987194 | 0.939136376 | 1.037710536 |
| GCST002094-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 3    | -0.02856 | 0.056477 | 0.613062 | 0.998683795 | -0.13926 | 0.082134 | 0.971843 | 0.87000599  | 1.085600993 |
| GCST006946-Worry too long after an embarrassing experience                                                                                                                            | Inverse variance weighted | 20   | -0.00054 | 0.001067 | 0.613893 | 0.998683795 | -0.00263 | 0.001553 | 0.999462 | 0.997373646 | 1.001554296 |
| GCST001415-Body mass index                                                                                                                                                            | Inverse variance weighted | 4    | 0.001219 | 0.002417 | 0.61406  | 0.998683795 | -0.00352 | 0.005956 | 1.00122  | 0.996487589 | 1.005974179 |
| GCST005956-Waist-to-hip ratio adjusted for BMI                                                                                                                                        | Inverse variance weighted | 43   | 0.049737 | 0.098754 | 0.614513 | 0.998683795 | -0.14382 | 0.243295 | 1.050994 | 0.866042628 | 1.275444318 |
| GCST000340-Myocardial infarction (early onset)                                                                                                                                        | Inverse variance weighted | 5    | -0.0396  | 0.078635 | 0.614585 | 0.998683795 | -0.19372 | 0.114529 | 0.961178 | 0.823888266 | 1.121344784 |
| GCST004350-Bone ultrasound measurement (velocity of sound)                                                                                                                            | Inverse variance weighted | 5    | 0.034829 | 0.069172 | 0.614609 | 0.998683795 | -0.10075 | 0.170406 | 1.035442 | 0.904159909 | 1.185786414 |
| GCST003117-Myocardial infarction                                                                                                                                                      | Inverse variance weighted | 16   | 0.262522 | 0.522156 | 0.615129 | 0.998683795 | -0.7609  | 1.285948 | 1.300205 | 0.467243922 | 3.618098012 |
| GCST003215-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 4    | -0.00399 | 0.007939 | 0.615374 | 0.998683795 | -0.01955 | 0.011572 | 0.996019 | 0.980640916 | 1.011638832 |
| GCST001399-Infantile hypertrophic pyloric stenosis                                                                                                                                    | Inverse variance weighted | 2    | -0.02775 | 0.055315 | 0.615964 | 0.998683795 | -0.13616 | 0.080673 | 0.972636 | 0.872700337 | 1.084016401 |
| GCST006194-Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test)                                                                                  | Inverse variance weighted | 2    | 0.0017   | 0.00339  | 0.615983 | 0.998683795 | -0.00494 | 0.008344 | 1.001702 | 0.995068641 | 1.008378582 |
| GCST006977-Predicted suicide risk                                                                                                                                                     | Inverse variance weighted | 2    | -0.12756 | 0.254393 | 0.61607  | 0.998683795 | -0.62617 | 0.371051 | 0.880241 | 0.534635382 | 1.449256666 |
| GCST006403-Energy expenditure                                                                                                                                                         | Inverse variance weighted | 4    | -0.00013 | 0.000258 | 0.616786 | 0.998683795 | -0.00063 | 0.000376 | 0.999871 | 0.99936611  | 1.000376233 |
| GCST006862-Asthma                                                                                                                                                                     | Inverse variance weighted | 15   | -0.03119 | 0.06235  | 0.616949 | 0.998683795 | -0.15339 | 0.091021 | 0.969295 | 0.857792301 | 1.095291467 |
| GCST000368-Fibrinogen                                                                                                                                                                 | Inverse variance weighted | 2    | 0.000685 | 0.001371 | 0.617147 | 0.998683795 | -0.002   | 0.003372 | 1.000686 | 0.998000448 | 1.003377797 |
| GCST000339-Eosinophil counts                                                                                                                                                          | Inverse variance weighted | 4    | 0.000644 | 0.001289 | 0.617576 | 0.998683795 | -0.00188 | 0.003171 | 1.000644 | 0.998118351 | 1.003176009 |
| GCST001007-Metabolic syndrome (bivariate traits)                                                                                                                                      | Inverse variance weighted | 10   | 0.01241  | 0.024875 | 0.617865 | 0.998683795 | -0.03635 | 0.061166 | 1.012487 | 0.964306558 | 1.063075021 |
| GCST004481-Low-grade serous and serous borderline ovarian cancer                                                                                                                      | Inverse variance weighted | 3    | -0.02791 | 0.055989 | 0.61814  | 0.998683795 | -0.13765 | 0.081829 | 0.972476 | 0.871404207 | 1.085270432 |
| GCST007339-Neuroticism                                                                                                                                                                | Inverse variance weighted | 167  | 0.067775 | 0.136627 | 0.619851 | 0.998683795 | -0.20001 | 0.335564 | 1.070125 | 0.818719796 | 1.398729134 |
| GCST005528-Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular)                                                                                 | Inverse variance weighted | 9    | -0.01858 | 0.037477 | 0.620024 | 0.998683795 | -0.09204 | 0.054873 | 0.98159  | 0.912072159 | 1.05640639  |
| GCST005038-Allergic disease (asthma, hay fever or eczema)                                                                                                                             | Inverse variance weighted | 80   | -0.02617 | 0.052876 | 0.620591 | 0.998683795 | -0.12981 | 0.077463 | 0.974165 | 0.87826042  | 1.080542488 |
| GCST005001-Shingles                                                                                                                                                                   | Inverse variance weighted | 2    | 0.086937 | 0.175829 | 0.620997 | 0.998683795 | -0.25769 | 0.431562 | 1.090828 | 0.772835592 | 1.539661268 |
| GCST000564-Electrocardiographic traits                                                                                                                                                | Inverse variance weighted | 2    | -0.00189 | 0.003821 | 0.62104  | 0.998683795 | -0.00938 | 0.0056   | 0.998113 | 0.990666027 | 1.005615634 |
| GCST005315-Acute lymphoblastic leukemia (childhood)                                                                                                                                   | Inverse variance weighted | 2    | -0.03466 | 0.070164 | 0.621292 | 0.998683795 | -0.17218 | 0.102859 | 0.965931 | 0.841824426 | 1.108335159 |
| GCST007302-Breast cancer in BRCA2 mutation carriers                                                                                                                                   | Inverse variance weighted | 3    | -0.02274 | 0.046243 | 0.622861 | 0.998683795 | -0.11338 | 0.067894 | 0.977514 | 0.892813108 | 1.07025147  |
| GCST001557-Venous thromboembolism                                                                                                                                                     | Inverse variance weighted | 3    | 0.011515 | 0.023443 | 0.623302 | 0.998683795 | -0.03443 | 0.057464 | 1.011581 | 0.966151773 | 1.059147251 |
| GCST004603-Platelet count                                                                                                                                                             | Inverse variance weighted | 128  | -0.08002 | 0.163287 | 0.624074 | 0.998683795 | -0.40007 | 0.240018 | 0.923094 | 0.670275595 | 1.27127163  |
| GCST002036-Congenital heart malformation                                                                                                                                              | Inverse variance weighted | 2    | 0.023037 | 0.047165 | 0.625239 | 0.998683795 | -0.06941 | 0.115481 | 1.023305 | 0.932947467 | 1.122413129 |
| GCST004601-Red blood cell count                                                                                                                                                       | Inverse variance weighted | 101  | -0.02201 | 0.04509  | 0.625494 | 0.998683795 | -0.11038 | 0.066368 | 0.978233 | 0.895490978 | 1.068620426 |
| GCST007327-Smoking status (ever vs never smokers)                                                                                                                                     | Inverse variance weighted | 145  | -0.05459 | 0.111953 | 0.625844 | 0.998683795 | -0.27401 | 0.164842 | 0.946876 | 0.760320727 | 1.179206254 |
| GCST007294-Body fat distribution (trunk fat ratio)                                                                                                                                    | Inverse variance weighted | 45   | -0.05727 | 0.11778  | 0.62681  | 0.998683795 | -0.28812 | 0.173581 | 0.944342 | 0.749674865 | 1.189557631 |
| GCST000414-Testicular germ cell tumor                                                                                                                                                 | Inverse variance weighted | 3    | 0.008362 | 0.017222 | 0.627276 | 0.998683795 | -0.02539 | 0.042117 | 1.008397 | 0.974927421 | 1.043016192 |
| GCST005763-Blood glucose levels                                                                                                                                                       | Inverse variance weighted | 2    | 0.008023 | 0.01656  | 0.628046 | 0.998683795 | -0.02444 | 0.040481 | 1.008055 | 0.975861102 | 1.041311739 |
| GCST007234-Acne (severe)                                                                                                                                                              | Inverse variance weighted | 9    | 0.020888 | 0.04312  | 0.628082 | 0.998683795 | -0.06363 | 0.105403 | 1.021108 | 0.93835559  | 1.111158575 |
| GCST000719-Alopecia areata                                                                                                                                                            | Inverse variance weighted | 3    | -0.01211 | 0.025008 | 0.628166 | 0.998683795 | -0.06113 | 0.036904 | 0.987961 | 0.9407037   | 1.037593352 |
| GCST006461-Self-reported risk-taking behaviour                                                                                                                                        | Inverse variance weighted | 7    | -0.07569 | 0.157702 | 0.631238 | 0.998683795 | -0.38479 | 0.233401 | 0.927099 | 0.680593718 | 1.262887381 |
| GCST004075-Vertical cup-disc ratio                                                                                                                                                    | Inverse variance weighted | 12   | -0.31739 | 0.66223  | 0.631738 | 0.998683795 | -1.61537 | 0.980575 | 0.728043 | 0.198818076 | 2.665988972 |
| GCST002333-Bone properties (heel)                                                                                                                                                     | Inverse variance weighted | 5    | 0.039592 | 0.082726 | 0.632228 | 0.998683795 | -0.12255 | 0.201736 | 1.040387 | 0.884660299 | 1.223525203 |
| GCST000563-Ankylosing spondylitis                                                                                                                                                     | Inverse variance weighted | 2    | -0.01887 | 0.039452 | 0.632379 | 0.998683795 | -0.0962  | 0.058453 | 0.981304 | 0.908282796 | 1.060195312 |
| GCST005146-Birth weight                                                                                                                                                               | Inverse variance weighted | 39   | -0.05326 | 0.111344 | 0.632425 | 0.998683795 | -0.27149 | 0.164977 | 0.948135 | 0.762240524 | 1.179366237 |
| GCST002173-Lipid traits                                                                                                                                                               | Inverse variance weighted | 2    | 0.00115  | 0.002404 | 0.632491 | 0.998683795 | -0.00356 | 0.005862 | 1.00115  | 0.996443831 | 1.005879228 |
| GCST007104-QRS duration                                                                                                                                                               | Inverse variance weighted | 18   | 0.004517 | 0.009509 | 0.634767 | 0.998683795 | -0.01412 | 0.023154 | 1.004527 | 0.985979082 | 1.023424049 |
| GCST001660-Neuroblastoma                                                                                                                                                              | Inverse variance weighted | 2    | 0.025285 | 0.053291 | 0.635165 | 0.998683795 | -0.07917 | 0.129735 | 1.025607 | 0.923887453 | 1.138526405 |
| GCST006903-Hip shape (DXA scan)                                                                                                                                                       | Inverse variance weighted | 7    | -0.03256 | 0.069032 | 0.637137 | 0.998683795 | -0.16787 | 0.10274  | 0.967962 | 0.845467824 | 1.108203037 |
| GCST007154-Paediatric migraine                                                                                                                                                        | Inverse variance weighted | 2    | 0.00786  | 0.016736 | 0.638594 | 0.998683795 | -0.02494 | 0.040663 | 1.007891 | 0.975366222 | 1.041500994 |
| GCST007839-Mouth ulcers                                                                                                                                                               | Inverse variance weighted | 48   | -0.0214  | 0.045571 | 0.638686 | 0.998683795 | -0.11072 | 0.067922 | 0.97883  | 0.895192363 | 1.070281916 |
| GCST004624-Sum eosinophil basophil counts                                                                                                                                             | Inverse variance weighted | 100  | -0.02414 | 0.051519 | 0.639373 | 0.998683795 | -0.12512 | 0.076837 | 0.976148 | 0.882392321 | 1.079866192 |
| GCST008276-Corneal resistance factor                                                                                                                                                  | Inverse variance weighted | 2    | -0.03342 | 0.071474 | 0.640048 | 0.998683795 | -0.17351 | 0.106666 | 0.967129 | 0.840706152 | 1.112562501 |
| GCST006801-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 4    | 0.026869 | 0.057621 | 0.640998 | 0.998683795 | -0.08607 | 0.139805 | 1.027233 | 0.917531969 | 1.150049973 |
| GCST007692-Chronic obstructive pulmonary disease                                                                                                                                      | Inverse variance weighted | 37   | -0.01908 | 0.041014 | 0.641841 | 0.998683795 | -0.09946 | 0.061311 | 0.981104 | 0.905322474 | 1.063229241 |
| GCST004338-Oleic acid (18:1n-9) levels                                                                                                                                                | Inverse variance weighted | 2    | 0.020167 | 0.04346  | 0.642613 | 0.998683795 | -0.06501 | 0.105349 | 1.020372 | 0.937054609 | 1.111097815 |
| GCST008109-Fasting blood proinsulin levels                                                                                                                                            | Inverse variance weighted | 4    | -0.16445 | 0.354652 | 0.64287  | 0.998683795 | -0.85957 | 0.53067  | 0.848361 | 0.423345176 | 1.700071575 |
| GCST008280-Intertrochanteric region size                                                                                                                                              | Inverse variance weighted | 5    | 0.057832 | 0.124973 | 0.643539 | 0.998683795 | -0.18711 | 0.302779 | 1.059537 | 0.829348451 | 1.353615347 |
| GCST000395-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 2    | -0.01593 | 0.034453 | 0.643823 | 0.998683795 | -0.08346 | 0.051598 | 0.984196 | 0.919929798 | 1.052952783 |
| GCST006423-Fractures                                                                                                                                                                  | Inverse variance weighted | 9    | -0.05836 | 0.126538 | 0.644674 | 0.998683795 | -0.30637 | 0.189658 | 0.943314 | 0.736114771 | 1.208835909 |
| GCST007401-Factor VII activity                                                                                                                                                        | Inverse variance weighted | 13   | -0.11224 | 0.243587 | 0.644966 | 0.998683795 | -0.58967 | 0.365194 | 0.893833 | 0.554511874 | 1.44079309  |
| GCST001967-Body mass index                                                                                                                                                            | Inverse variance weighted | 6    | 0.104857 | 0.227927 | 0.645485 | 0.998683795 | -0.34188 | 0.551594 | 1.110551 | 0.710432712 | 1.73601853  |
| GCST007987-Daytime nap                                                                                                                                                                | Inverse variance weighted | 5    | 0.056055 | 0.12239  | 0.646952 | 0.998683795 | -0.18383 | 0.29594  | 1.057656 | 0.83207714  | 1.344389148 |
| GCST002455-Parkinson's disease                                                                                                                                                        | Inverse variance weighted | 2    | -0.01735 | 0.037903 | 0.647128 | 0.998683795 | -0.09164 | 0.05694  | 0.982799 | 0.912432995 | 1.058592119 |
| GCST003659-Modified Stumvoll Insulin Sensitivity Index (BMI interaction)                                                                                                              | Inverse variance weighted | 5    | 0.388607 | 0.84899  | 0.647147 | 0.998683795 | -1.27541 | 2.052627 | 1.474925 | 0.27931578  | 7.788335005 |
| GCST007799-Asthma (adult onset)                                                                                                                                                       | Inverse variance weighted | 4    | -0.16405 | 0.359492 | 0.648157 | 0.998683795 | -0.86865 | 0.54056  | 0.848704 | 0.419517455 | 1.716968189 |
| GCST003127-Lipoprotein (a) levels                                                                                                                                                     | Inverse variance weighted | 4    | -0.02425 | 0.053351 | 0.649404 | 0.998683795 | -0.12882 | 0.080315 | 0.976039 | 0.879132219 | 1.083627975 |
| GCST007995-Asthma (childhood onset)                                                                                                                                                   | Inverse variance weighted | 36   | -0.01324 | 0.029189 | 0.650071 | 0.998683795 | -0.07045 | 0.043969 | 0.986845 | 0.931971027 | 1.044950109 |
| GCST007778-Urinary sodium to creatinine ratio                                                                                                                                         | Inverse variance weighted | 2    | 0.19684  | 0.434115 | 0.65024  | 0.998683795 | -0.65403 | 1.047706 | 1.217549 | 0.51994831  | 2.85110379  |
| GCST007797-Asthma onset (childhood vs adult)                                                                                                                                          | Inverse variance weighted | 18   | -0.01901 | 0.042091 | 0.651607 | 0.998683795 | -0.1015  | 0.063494 | 0.981174 | 0.903476948 | 1.065552632 |
| GCST001364-IgA nephropathy                                                                                                                                                            | Inverse variance weighted | 5    | -0.03853 | 0.085434 | 0.651993 | 0.998683795 | -0.20598 | 0.128921 | 0.962202 | 0.8138482   | 1.137599708 |
| GCST004331-Hemoglobin                                                                                                                                                                 | Inverse variance weighted | 2    | -0.1055  | 0.234157 | 0.652307 | 0.998683795 | -0.56445 | 0.353445 | 0.899873 | 0.56867369  | 1.423965373 |
| GCST001021-Iron status biomarkers                                                                                                                                                     | Inverse variance weighted | 2    | 0.000239 | 0.000532 | 0.652345 | 0.998683795 | -0.0008  | 0.001281 | 1.00024  | 0.999197892 | 1.00128222  |
| GCST001099-Sudden cardiac arrest                                                                                                                                                      | Inverse variance weighted | 8    | 0.011072 | 0.024609 | 0.652758 | 0.998683795 | -0.03716 | 0.059306 | 1.011134 | 0.963521108 | 1.061099447 |
| GCST001628-Orofacial clefts                                                                                                                                                           | Inverse variance weighted | 9    | 0.007426 | 0.016516 | 0.652999 | 0.998683795 | -0.02495 | 0.039798 | 1.007453 | 0.975362419 | 1.040600121 |
| GCST001791-Urate levels                                                                                                                                                               | Inverse variance weighted | 21   | 0.018371 | 0.040863 | 0.653012 | 0.998683795 | -0.06172 | 0.098463 | 1.018541 | 0.940145691 | 1.103473706 |
| GCST002945-Emphysema imaging phenotypes                                                                                                                                               | Inverse variance weighted | 2    | -0.04546 | 0.101227 | 0.653392 | 0.998683795 | -0.24386 | 0.152948 | 0.955561 | 0.783596839 | 1.165264219 |
| GCST006621-Midgestational cytokine/chemokine levels (maternal genetic effect)                                                                                                         | Inverse variance weighted | 3    | -0.00929 | 0.020708 | 0.653694 | 0.998683795 | -0.04988 | 0.031297 | 0.990753 | 0.951345555 | 1.031792144 |
| GCST001350-Pancreatic cancer                                                                                                                                                          | Inverse variance weighted | 3    | -0.01817 | 0.040523 | 0.653882 | 0.998683795 | -0.09759 | 0.061256 | 0.981995 | 0.907016506 | 1.063170538 |
| GCST002463-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 7    | 0.010879 | 0.024379 | 0.655436 | 0.998683795 | -0.0369  | 0.058662 | 1.010938 | 0.963767961 | 1.060416614 |
| GCST000464-Acute lymphoblastic leukemia (childhood)                                                                                                                                   | Inverse variance weighted | 2    | -0.01453 | 0.032588 | 0.655761 | 0.998683795 | -0.0784  | 0.049345 | 0.985578 | 0.924595789 | 1.050582931 |
| GCST000657-Optic nerve measurement (disc area)                                                                                                                                        | Inverse variance weighted | 2    | 0.019706 | 0.044254 | 0.656117 | 0.998683795 | -0.06703 | 0.106444 | 1.019901 | 0.9351644   | 1.112315887 |
| GCST002140-Multiple myeloma                                                                                                                                                           | Inverse variance weighted | 3    | -0.02543 | 0.057358 | 0.657543 | 0.998683795 | -0.13785 | 0.086994 | 0.974893 | 0.871231065 | 1.090889927 |
| GCST007561-Sleep duration                                                                                                                                                             | Inverse variance weighted | 34   | -0.00158 | 0.003582 | 0.659332 | 0.998683795 | -0.0086  | 0.005442 | 0.998422 | 0.991436708 | 1.005456717 |
| GCST002149-Schizophrenia                                                                                                                                                              | Inverse variance weighted | 12   | 0.029127 | 0.066129 | 0.659606 | 0.998683795 | -0.10049 | 0.158741 | 1.029556 | 0.904397336 | 1.172034136 |
| GCST001126-Parkinson's disease                                                                                                                                                        | Inverse variance weighted | 2    | -0.02851 | 0.06477  | 0.65981  | 0.998683795 | -0.15546 | 0.098438 | 0.971893 | 0.856022824 | 1.10344633  |
| GCST003358-Betaine levels in individuals undergoing cardiac evaluation                                                                                                                | Inverse variance weighted | 2    | -0.16473 | 0.374741 | 0.660233 | 0.998683795 | -0.89923 | 0.569759 | 0.84812  | 0.406884735 | 1.767841798 |
| GCST000383-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 4    | -0.01752 | 0.039956 | 0.661123 | 0.998683795 | -0.09583 | 0.060799 | 0.982637 | 0.90861852  | 1.062685376 |
| GCST002535-PR interval                                                                                                                                                                | Inverse variance weighted | 2    | 0.002067 | 0.004724 | 0.661768 | 0.998683795 | -0.00719 | 0.011326 | 1.002069 | 0.992832969 | 1.011390711 |
| GCST002842-Basal cell carcinoma                                                                                                                                                       | Inverse variance weighted | 2    | 0.025115 | 0.057427 | 0.661864 | 0.998683795 | -0.08744 | 0.137672 | 1.025433 | 0.916272102 | 1.147599418 |
| GCST000730-Bilirubin levels                                                                                                                                                           | Inverse variance weighted | 2    | 0.041096 | 0.094096 | 0.662295 | 0.998683795 | -0.14333 | 0.225524 | 1.041952 | 0.86646645  | 1.252979005 |
| GCST000561-Electrocardiographic traits                                                                                                                                                | Inverse variance weighted | 8    | -0.00029 | 0.00066  | 0.663165 | 0.998683795 | -0.00158 | 0.001006 | 0.999713 | 0.998420891 | 1.001006196 |
| GCST000295-Bone mineral density (spine)                                                                                                                                               | Inverse variance weighted | 2    | 0.044928 | 0.103204 | 0.66332  | 0.998683795 | -0.15735 | 0.247207 | 1.045953 | 0.854403905 | 1.280444521 |
| GCST001674-Esophageal cancer (squamous cell)                                                                                                                                          | Inverse variance weighted | 6    | 0.016549 | 0.038121 | 0.664201 | 0.998683795 | -0.05817 | 0.091266 | 1.016687 | 0.943491621 | 1.0955603   |
| GCST002763-Optic disc area                                                                                                                                                            | Inverse variance weighted | 8    | 0.086443 | 0.199467 | 0.664744 | 0.998683795 | -0.30451 | 0.477399 | 1.09029  | 0.737483459 | 1.611875825 |
| GCST000707-Hair color                                                                                                                                                                 | Inverse variance weighted | 4    | -0.00749 | 0.017289 | 0.664868 | 0.998683795 | -0.04138 | 0.026397 | 0.992538 | 0.959467554 | 1.026748743 |
| GCST003664-Metabolite levels (lipid measures)                                                                                                                                         | Inverse variance weighted | 3    | 0.018731 | 0.043397 | 0.666019 | 0.998683795 | -0.06633 | 0.10379  | 1.018908 | 0.935824203 | 1.109367113 |
| GCST000651-Creatinine levels                                                                                                                                                          | Inverse variance weighted | 2    | -0.01206 | 0.028089 | 0.667637 | 0.998683795 | -0.06712 | 0.042993 | 0.988011 | 0.935087048 | 1.0439308   |
| GCST007089-Polycystic ovary syndrome                                                                                                                                                  | Inverse variance weighted | 6    | -0.02595 | 0.060547 | 0.668258 | 0.998683795 | -0.14462 | 0.092725 | 0.974387 | 0.865352462 | 1.097159923 |
| GCST007954-Glycated hemoglobin levels                                                                                                                                                 | Inverse variance weighted | 28   | -0.09275 | 0.216469 | 0.668324 | 0.998683795 | -0.51703 | 0.331533 | 0.911425 | 0.596291705 | 1.393102385 |
| GCST002083-Self-reported allergy                                                                                                                                                      | Inverse variance weighted | 11   | -0.02616 | 0.061321 | 0.669702 | 0.998683795 | -0.14635 | 0.094032 | 0.974182 | 0.863859316 | 1.098594698 |
| GCST007847-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 51   | -0.01319 | 0.030954 | 0.669951 | 0.998683795 | -0.07386 | 0.047477 | 0.986894 | 0.928798782 | 1.048622026 |
| GCST005013-Childhood ear infection                                                                                                                                                    | Inverse variance weighted | 6    | -0.04284 | 0.100816 | 0.670851 | 0.998683795 | -0.24044 | 0.154754 | 0.95806  | 0.786279288 | 1.167370634 |
| GCST001010-Primary biliary cholangitis                                                                                                                                                | Inverse variance weighted | 15   | -0.00774 | 0.01823  | 0.671347 | 0.998683795 | -0.04347 | 0.027996 | 0.992295 | 0.957464483 | 1.028391961 |
| GCST004899-Gestational age at birth (maternal effect)                                                                                                                                 | Inverse variance weighted | 2    | -0.006   | 0.014194 | 0.672257 | 0.998683795 | -0.03382 | 0.021815 | 0.994013 | 0.966741701 | 1.022054409 |
| GCST007708-Worry/vulnerability (special factor of neuroticism)                                                                                                                        | Inverse variance weighted | 10   | 0.277211 | 0.65689  | 0.673021 | 0.998683795 | -1.01029 | 1.564715 | 1.319445 | 0.364112342 | 4.78131254  |
| GCST000804-Asthma                                                                                                                                                                     | Inverse variance weighted | 3    | -0.02794 | 0.06628  | 0.673341 | 0.998683795 | -0.15785 | 0.101968 | 0.972445 | 0.853976792 | 1.107348005 |
| GCST002496-Bone mineral density (paediatric, upper limb)                                                                                                                              | Inverse variance weighted | 4    | 0.026621 | 0.063259 | 0.673886 | 0.998683795 | -0.09737 | 0.150609 | 1.026978 | 0.907222735 | 1.162541961 |
| GCST004635-Testicular germ cell tumor                                                                                                                                                 | Inverse variance weighted | 24   | 0.007687 | 0.018364 | 0.675507 | 0.998683795 | -0.02831 | 0.043681 | 1.007717 | 0.972090228 | 1.044649349 |
| GCST001038-Dehydroepiandrosterone sulphate levels                                                                                                                                     | Inverse variance weighted | 6    | -0.07959 | 0.190288 | 0.675771 | 0.998683795 | -0.45255 | 0.293378 | 0.923498 | 0.636003586 | 1.340950102 |
| GCST005077-Breast cancer                                                                                                                                                              | Inverse variance weighted | 4    | 0.061466 | 0.147062 | 0.675976 | 0.998683795 | -0.22678 | 0.349708 | 1.063395 | 0.797099719 | 1.418653126 |
| GCST003429-Morning vs. evening chronotype                                                                                                                                             | Inverse variance weighted | 5    | -0.06061 | 0.145039 | 0.676048 | 0.998683795 | -0.34488 | 0.223671 | 0.941194 | 0.708302997 | 1.250658965 |
| GCST003586-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 3    | 0.014022 | 0.033606 | 0.676501 | 0.998683795 | -0.05185 | 0.079889 | 1.01412  | 0.949475706 | 1.083166508 |
| GCST001796-Prostate-specific antigen levels                                                                                                                                           | Inverse variance weighted | 2    | -0.05313 | 0.12745  | 0.676767 | 0.998683795 | -0.30293 | 0.196671 | 0.948256 | 0.738648182 | 1.217343515 |
| GCST000683-Central corneal thickness                                                                                                                                                  | Inverse variance weighted | 2    | 0.032323 | 0.078091 | 0.678935 | 0.998683795 | -0.12073 | 0.185381 | 1.032851 | 0.886269184 | 1.203676513 |
| GCST001807-Tetralogy of Fallot                                                                                                                                                        | Inverse variance weighted | 2    | -0.01731 | 0.041885 | 0.679467 | 0.998683795 | -0.0994  | 0.064787 | 0.982843 | 0.905380551 | 1.066932129 |
| GCST000498-Hematological parameters                                                                                                                                                   | Inverse variance weighted | 6    | 0.000855 | 0.002078 | 0.680747 | 0.998683795 | -0.00322 | 0.004927 | 1.000855 | 0.996787734 | 1.004939313 |
| GCST007114-Cholesterol efflux capacity                                                                                                                                                | Inverse variance weighted | 3    | 0.029107 | 0.071025 | 0.681939 | 0.998683795 | -0.1101  | 0.168317 | 1.029535 | 0.895742898 | 1.183311198 |
| GCST000317-Obesity                                                                                                                                                                    | Inverse variance weighted | 3    | -0.01965 | 0.048324 | 0.684281 | 0.998683795 | -0.11436 | 0.075065 | 0.980542 | 0.891932772 | 1.077954018 |
| GCST001527-Fasting blood glucose (BMI interaction)                                                                                                                                    | Inverse variance weighted | 18   | 2.816583 | 6.933952 | 0.684594 | 0.998683795 | -10.774  | 16.40713 | 16.71962 | 2.09376E-05 | 13351349.21 |
| GCST006414-Atrial fibrillation                                                                                                                                                        | Inverse variance weighted | 89   | 0.012384 | 0.030494 | 0.684653 | 0.998683795 | -0.04738 | 0.072152 | 1.012461 | 0.953721577 | 1.074818478 |
| GCST004634-Basophil percentage of granulocytes                                                                                                                                        | Inverse variance weighted | 25   | -0.03991 | 0.098713 | 0.685971 | 0.998683795 | -0.23339 | 0.153565 | 0.960873 | 0.791844256 | 1.165983891 |
| GCST001234-Gamma glutamyl transpeptidase                                                                                                                                              | Inverse variance weighted | 4    | 0.681962 | 1.68756  | 0.686131 | 0.998683795 | -2.62565 | 3.989579 | 1.977755 | 0.072392354 | 54.03216343 |
| GCST002255-Inflammatory biomarkers                                                                                                                                                    | Inverse variance weighted | 3    | -0.05987 | 0.148384 | 0.686571 | 0.998683795 | -0.35071 | 0.230958 | 0.941882 | 0.704189688 | 1.259805884 |
| GCST002450-Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid)                                                                                                    | Inverse variance weighted | 2    | 0.292189 | 0.727143 | 0.687808 | 0.998683795 | -1.13301 | 1.717389 | 1.339357 | 0.322062292 | 5.569965464 |
| GCST003818-Resting heart rate                                                                                                                                                         | Inverse variance weighted | 49   | 0.00293  | 0.0073   | 0.688181 | 0.998683795 | -0.01138 | 0.017238 | 1.002934 | 0.988686032 | 1.017387297 |
| GCST000775-Central corneal thickness                                                                                                                                                  | Inverse variance weighted | 3    | 0.029405 | 0.0736   | 0.689507 | 0.998683795 | -0.11485 | 0.173662 | 1.029842 | 0.891498306 | 1.18965361  |
| GCST005434-Pancreatic cancer                                                                                                                                                          | Inverse variance weighted | 11   | 0.019489 | 0.049005 | 0.690861 | 0.998683795 | -0.07656 | 0.115539 | 1.01968  | 0.926295877 | 1.122478453 |
| GCST000191-Black vs. red hair color                                                                                                                                                   | Inverse variance weighted | 3    | -0.01849 | 0.046587 | 0.691527 | 0.998683795 | -0.1098  | 0.072826 | 0.981685 | 0.896017198 | 1.075543009 |
| GCST007462-Age of smoking initiation (MTAG)                                                                                                                                           | Inverse variance weighted | 99   | -0.07376 | 0.185953 | 0.691599 | 0.998683795 | -0.43823 | 0.290702 | 0.92889  | 0.645175902 | 1.337366567 |
| GCST003641-Cranial base width                                                                                                                                                         | Inverse variance weighted | 2    | -0.01032 | 0.02607  | 0.692219 | 0.998683795 | -0.06142 | 0.040777 | 0.989734 | 0.940431987 | 1.041619673 |
| GCST002882-Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor                                                                                     | Inverse variance weighted | 2    | 0.069996 | 0.176954 | 0.69243  | 0.998683795 | -0.27683 | 0.416825 | 1.072504 | 0.758180643 | 1.517137301 |
| GCST001416-Body mass index (SNP x SNP interaction)                                                                                                                                    | Inverse variance weighted | 7    | 0.053536 | 0.13581  | 0.693434 | 0.998683795 | -0.21265 | 0.319725 | 1.054995 | 0.808437306 | 1.376748678 |
| GCST004627-Lymphocyte counts                                                                                                                                                          | Inverse variance weighted | 86   | 0.024291 | 0.061749 | 0.694032 | 0.998683795 | -0.09674 | 0.14532  | 1.024589 | 0.907794885 | 1.15640922  |
| GCST003170-Subcutaneous adipose tissue                                                                                                                                                | Inverse variance weighted | 2    | 5.71E-05 | 0.000145 | 0.694059 | 0.998683795 | -0.00023 | 0.000341 | 1.000057 | 0.999772695 | 1.000341545 |
| GCST000134-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 4    | 0.025294 | 0.064367 | 0.694342 | 0.998683795 | -0.10086 | 0.151453 | 1.025617 | 0.904055144 | 1.163524127 |
| GCST004525-Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan)                                                             | Inverse variance weighted | 2    | 0.164005 | 0.419991 | 0.696169 | 0.998683795 | -0.65918 | 0.987187 | 1.178221 | 0.517277039 | 2.683675961 |
| GCST006479-Diverticular disease                                                                                                                                                       | Inverse variance weighted | 27   | 0.347449 | 0.89059  | 0.696438 | 0.998683795 | -1.39811 | 2.093005 | 1.415451 | 0.247063961 | 8.109247354 |
| GCST004630-Mean corpuscular hemoglobin                                                                                                                                                | Inverse variance weighted | 112  | 0.013575 | 0.034809 | 0.69655  | 0.998683795 | -0.05465 | 0.081801 | 1.013668 | 0.946815211 | 1.085240235 |
| GCST002764-Optic cup area                                                                                                                                                             | Inverse variance weighted | 4    | 0.362863 | 0.93053  | 0.696571 | 0.998683795 | -1.46098 | 2.186702 | 1.437439 | 0.232009702 | 8.905794081 |
| GCST004335-Mean corpuscular volume                                                                                                                                                    | Inverse variance weighted | 3    | -0.0085  | 0.021807 | 0.696833 | 0.998683795 | -0.05124 | 0.034246 | 0.99154  | 0.95005176  | 1.034839612 |
| GCST001653-Androgen levels                                                                                                                                                            | Inverse variance weighted | 2    | 0.044711 | 0.11529  | 0.698156 | 0.998683795 | -0.18126 | 0.27068  | 1.045725 | 0.834220132 | 1.310854939 |
| GCST004076-Optic disc area                                                                                                                                                            | Inverse variance weighted | 8    | -0.08748 | 0.225928 | 0.698602 | 0.998683795 | -0.5303  | 0.355337 | 0.916236 | 0.588428581 | 1.426661954 |
| GCST001780-Mean corpuscular hemoglobin                                                                                                                                                | Inverse variance weighted | 3    | -0.01946 | 0.050477 | 0.699784 | 0.998683795 | -0.1184  | 0.07947  | 0.980724 | 0.888341369 | 1.082713252 |
| GCST006951-Feeling hurt                                                                                                                                                               | Inverse variance weighted | 20   | -0.00026 | 0.000687 | 0.700082 | 0.998683795 | -0.00161 | 0.001082 | 0.999735 | 0.998389857 | 1.001082656 |
| GCST001456-Kawasaki disease                                                                                                                                                           | Inverse variance weighted | 2    | -0.01263 | 0.032807 | 0.700201 | 0.998683795 | -0.07693 | 0.051669 | 0.987447 | 0.925951421 | 1.053027237 |
| GCST000364-QT interval                                                                                                                                                                | Inverse variance weighted | 9    | 0.001397 | 0.003635 | 0.700653 | 0.998683795 | -0.00573 | 0.008522 | 1.001398 | 0.994289221 | 1.008558422 |
| GCST001158-Fibrinogen                                                                                                                                                                 | Inverse variance weighted | 3    | 0.020652 | 0.054078 | 0.702535 | 0.998683795 | -0.08534 | 0.126645 | 1.020867 | 0.918199895 | 1.135013818 |
| GCST002350-Chronic obstructive pulmonary disease (severe)                                                                                                                             | Inverse variance weighted | 2    | -0.01325 | 0.034728 | 0.702712 | 0.998683795 | -0.08132 | 0.054812 | 0.986833 | 0.921897847 | 1.056342297 |
| GCST006284-Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease                                                                              | Inverse variance weighted | 3    | 0.0725   | 0.189995 | 0.702768 | 0.998683795 | -0.29989 | 0.44489  | 1.075192 | 0.740899321 | 1.560317933 |
| GCST001198-Multiple sclerosis                                                                                                                                                         | Inverse variance weighted | 39   | -0.0091  | 0.023916 | 0.703651 | 0.998683795 | -0.05597 | 0.037778 | 0.990944 | 0.945564203 | 1.03850086  |
| GCST006625-Neonatal cytokine/chemokine levels (maternal genetic effect)                                                                                                               | Inverse variance weighted | 2    | -0.01085 | 0.02857  | 0.704045 | 0.998683795 | -0.06685 | 0.045145 | 0.989206 | 0.935335219 | 1.046179204 |
| GCST000051-Atrial fibrillation/atrial flutter                                                                                                                                         | Inverse variance weighted | 2    | -0.01486 | 0.039134 | 0.704104 | 0.998683795 | -0.09156 | 0.06184  | 0.985247 | 0.912502181 | 1.063791907 |
| GCST006366-Central corneal thickness                                                                                                                                                  | Inverse variance weighted | 6    | 0.001332 | 0.003507 | 0.704189 | 0.998683795 | -0.00554 | 0.008206 | 1.001333 | 0.994472609 | 1.008239752 |
| GCST004861-Itch intensity from mosquito bite                                                                                                                                          | Inverse variance weighted | 26   | 0.048019 | 0.127093 | 0.70556  | 0.998683795 | -0.20108 | 0.29712  | 1.04919  | 0.817845014 | 1.345977137 |
| GCST003389-Bone mineral density (hip)                                                                                                                                                 | Inverse variance weighted | 3    | -0.05424 | 0.143561 | 0.705577 | 0.998683795 | -0.33562 | 0.227142 | 0.947207 | 0.714895848 | 1.255008665 |
| GCST000056-Restless legs syndrome                                                                                                                                                     | Inverse variance weighted | 3    | 0.00794  | 0.021075 | 0.706379 | 0.998683795 | -0.03337 | 0.049247 | 1.007971 | 0.967182474 | 1.050480049 |
| GCST004565-Waist circumference adjusted for BMI in inactive individuals                                                                                                               | Inverse variance weighted | 2    | -0.13448 | 0.357242 | 0.706595 | 0.998683795 | -0.83467 | 0.565717 | 0.874172 | 0.434016438 | 1.760709723 |
| GCST007932-Medication use (thyroid preparations)                                                                                                                                      | Inverse variance weighted | 86   | -0.00807 | 0.021465 | 0.706991 | 0.998683795 | -0.05014 | 0.034003 | 0.991964 | 0.951095644 | 1.034587809 |
| GCST006075-Hair color                                                                                                                                                                 | Inverse variance weighted | 15   | 0.012421 | 0.033049 | 0.70704  | 0.998683795 | -0.05235 | 0.077196 | 1.012498 | 0.948992483 | 1.080253759 |
| GCST001870-Bone mineral density                                                                                                                                                       | Inverse variance weighted | 4    | -0.02588 | 0.069128 | 0.708119 | 0.998683795 | -0.16137 | 0.10961  | 0.974452 | 0.850976165 | 1.115843232 |
| GCST002667-Mammographic density (dense area)                                                                                                                                          | Inverse variance weighted | 6    | 0.020197 | 0.0541   | 0.708899 | 0.998683795 | -0.08584 | 0.126233 | 1.020403 | 0.917742617 | 1.134546625 |
| GCST002305-Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)                                            | Inverse variance weighted | 2    | -0.02032 | 0.054784 | 0.710727 | 0.998683795 | -0.1277  | 0.087059 | 0.979887 | 0.880121316 | 1.090960783 |
| GCST002840-Myeloproliferative neoplasms                                                                                                                                               | Inverse variance weighted | 2    | 0.02515  | 0.06794  | 0.711242 | 0.998683795 | -0.10801 | 0.158312 | 1.025469 | 0.897617439 | 1.171531957 |
| GCST003838-Morning vs. evening chronotype                                                                                                                                             | Inverse variance weighted | 3    | 0.08024  | 0.217233 | 0.711852 | 0.998683795 | -0.34554 | 0.506017 | 1.083547 | 0.70783959  | 1.658671363 |
| GCST006279-Cerebrospinal fluid α-synuclein levels                                                                                                                                     | Inverse variance weighted | 2    | -0.04245 | 0.11546  | 0.713116 | 0.998683795 | -0.26875 | 0.183849 | 0.958437 | 0.764332416 | 1.201834851 |
| GCST001806-Corneal structure                                                                                                                                                          | Inverse variance weighted | 20   | 0.015693 | 0.042739 | 0.713476 | 0.998683795 | -0.06808 | 0.099462 | 1.015817 | 0.934190117 | 1.10457682  |
| GCST000288-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 6    | 0.026527 | 0.072595 | 0.71481  | 0.998683795 | -0.11576 | 0.168813 | 1.026881 | 0.890689223 | 1.183898408 |
| GCST005561-Aortic valve stenosis                                                                                                                                                      | Inverse variance weighted | 3    | -0.02087 | 0.057156 | 0.715016 | 0.998683795 | -0.1329  | 0.091157 | 0.979347 | 0.875556041 | 1.09544123  |
| GCST000829-Waist-hip ratio                                                                                                                                                            | Inverse variance weighted | 8    | 0.076304 | 0.209027 | 0.715078 | 0.998683795 | -0.33339 | 0.485998 | 1.079291 | 0.71649108  | 1.625797219 |
| GCST001217-Metabolic traits                                                                                                                                                           | Inverse variance weighted | 27   | -0.01069 | 0.029322 | 0.715507 | 0.998683795 | -0.06816 | 0.046783 | 0.98937  | 0.934113602 | 1.047895101 |
| GCST004562-Waist circumference adjusted for body mass index                                                                                                                           | Inverse variance weighted | 78   | -0.02829 | 0.077783 | 0.716089 | 0.998683795 | -0.18074 | 0.124166 | 0.972107 | 0.834649259 | 1.132203481 |
| GCST006613-Triglycerides                                                                                                                                                              | Inverse variance weighted | 82   | 0.0203   | 0.055962 | 0.716798 | 0.998683795 | -0.08939 | 0.129985 | 1.020507 | 0.91449265  | 1.138811794 |
| GCST007576-Chronotype                                                                                                                                                                 | Inverse variance weighted | 41   | -0.09667 | 0.266854 | 0.717168 | 0.998683795 | -0.6197  | 0.426366 | 0.907858 | 0.538105914 | 1.531681813 |
| GCST000915-Primary sclerosing cholangitis                                                                                                                                             | Inverse variance weighted | 2    | -0.01647 | 0.045458 | 0.717178 | 0.998683795 | -0.10556 | 0.072631 | 0.983669 | 0.899817639 | 1.075333263 |
| GCST001072-Blood pressure                                                                                                                                                             | Inverse variance weighted | 4    | 0.003973 | 0.010998 | 0.717949 | 0.998683795 | -0.01758 | 0.025529 | 1.00398  | 0.982569697 | 1.025857813 |
| GCST005845-Heart rate increase in response to exercise                                                                                                                                | Inverse variance weighted | 8    | -0.04672 | 0.129484 | 0.718239 | 0.998683795 | -0.30051 | 0.207069 | 0.954355 | 0.740441738 | 1.23006771  |
| GCST006065-Glaucoma (primary open-angle)                                                                                                                                              | Inverse variance weighted | 29   | 0.010539 | 0.029229 | 0.718417 | 0.998683795 | -0.04675 | 0.067827 | 1.010595 | 0.954326969 | 1.070180262 |
| GCST007664-Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer                                                                           | Inverse variance weighted | 2    | -0.01594 | 0.044319 | 0.719026 | 0.998683795 | -0.10281 | 0.070921 | 0.984182 | 0.902298511 | 1.073496752 |
| GCST007837-Glycine levels                                                                                                                                                             | Inverse variance weighted | 4    | -0.01152 | 0.032092 | 0.719545 | 0.998683795 | -0.07442 | 0.051377 | 0.988543 | 0.928278833 | 1.052719569 |
| GCST001579-Age-related macular degeneration (choroidal neovascularisation)                                                                                                            | Inverse variance weighted | 2    | -0.0095  | 0.026502 | 0.71993  | 0.998683795 | -0.06145 | 0.042441 | 0.990543 | 0.940404039 | 1.043354641 |
| GCST000286-Triglycerides                                                                                                                                                              | Inverse variance weighted | 7    | 0.022014 | 0.061691 | 0.721205 | 0.998683795 | -0.0989  | 0.142929 | 1.022258 | 0.905833205 | 1.153647665 |
| GCST000181-Bone mineral density (hip)                                                                                                                                                 | Inverse variance weighted | 4    | -0.0288  | 0.08077  | 0.721402 | 0.998683795 | -0.18711 | 0.129509 | 0.971609 | 0.829351039 | 1.138268832 |
| GCST003566-Multiple sclerosis                                                                                                                                                         | Inverse variance weighted | 3    | 0.025092 | 0.070387 | 0.721482 | 0.998683795 | -0.11287 | 0.16305  | 1.025409 | 0.893269077 | 1.177096111 |
| GCST007241-Obesity (extreme)                                                                                                                                                          | Inverse variance weighted | 6    | -0.0138  | 0.038781 | 0.722048 | 0.998683795 | -0.08981 | 0.062216 | 0.986299 | 0.91410751  | 1.064192398 |
| GCST005672-Cholesteryl ester transfer protein levels                                                                                                                                  | Inverse variance weighted | 3    | -0.01293 | 0.03635  | 0.722104 | 0.998683795 | -0.08417 | 0.058318 | 0.987155 | 0.919271212 | 1.060052465 |
| GCST002643-Follicular lymphoma                                                                                                                                                        | Inverse variance weighted | 4    | 0.023874 | 0.067313 | 0.722837 | 0.998683795 | -0.10806 | 0.155808 | 1.024161 | 0.89757367  | 1.168601953 |
| GCST000117-Blue vs. green eyes                                                                                                                                                        | Inverse variance weighted | 2    | 0.007012 | 0.019849 | 0.723879 | 0.998683795 | -0.03189 | 0.045915 | 1.007037 | 0.968612158 | 1.046985575 |
| GCST004599-Mean platelet volume                                                                                                                                                       | Inverse variance weighted | 136  | 0.012462 | 0.035481 | 0.725412 | 0.998683795 | -0.05708 | 0.082004 | 1.01254  | 0.944518649 | 1.085460049 |
| GCST000283-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 2    | 0.030637 | 0.087384 | 0.725888 | 0.998683795 | -0.14064 | 0.201909 | 1.031111 | 0.868805683 | 1.223737241 |
| GCST002678-Iron status biomarkers (transferrin levels)                                                                                                                                | Inverse variance weighted | 7    | 0.018243 | 0.05204  | 0.725919 | 0.998683795 | -0.08375 | 0.120241 | 1.01841  | 0.919656748 | 1.127768365 |
| GCST000753-Metabolic syndrome                                                                                                                                                         | Inverse variance weighted | 2    | 0.072359 | 0.206416 | 0.725928 | 0.998683795 | -0.33222 | 0.476935 | 1.075041 | 0.717331481 | 1.611128453 |
| GCST002765-Optic disc area                                                                                                                                                            | Inverse variance weighted | 2    | -0.05831 | 0.166466 | 0.726127 | 0.998683795 | -0.38458 | 0.267964 | 0.943357 | 0.680733879 | 1.307299469 |
| GCST002697-Eosinophilic esophagitis                                                                                                                                                   | Inverse variance weighted | 3    | -0.01171 | 0.033499 | 0.726582 | 0.998683795 | -0.07737 | 0.053944 | 0.988355 | 0.92554627  | 1.055425231 |
| GCST006922-Regular attendance at a religious group                                                                                                                                    | Inverse variance weighted | 10   | -0.42154 | 1.211906 | 0.727968 | 0.998683795 | -2.79687 | 1.953799 | 0.656037 | 0.061000477 | 7.055439583 |
| GCST006482-Lung function (FEV1/FVC)                                                                                                                                                   | Inverse variance weighted | 11   | 0.789229 | 2.269799 | 0.728059 | 0.998683795 | -3.65958 | 5.238035 | 2.201697 | 0.025743372 | 188.2997527 |
| GCST006067-Glaucoma (primary open-angle)                                                                                                                                              | Inverse variance weighted | 5    | -0.01629 | 0.046876 | 0.72819  | 0.998683795 | -0.10817 | 0.075586 | 0.983841 | 0.897477064 | 1.07851567  |
| GCST006258-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 31   | -0.00599 | 0.01724  | 0.728193 | 0.998683795 | -0.03978 | 0.027799 | 0.994026 | 0.960998932 | 1.028189081 |
| GCST000542-Pulmonary function                                                                                                                                                         | Inverse variance weighted | 5    | 0.000177 | 0.000513 | 0.729728 | 0.998683795 | -0.00083 | 0.001183 | 1.000177 | 0.999172178 | 1.0011833   |
| GCST000631-Activated partial thromboplastin time                                                                                                                                      | Inverse variance weighted | 3    | -0.00969 | 0.028077 | 0.730081 | 0.998683795 | -0.06472 | 0.045343 | 0.99036  | 0.937332686 | 1.046386881 |
| GCST006101-Cardiometabolic and hematological traits                                                                                                                                   | Inverse variance weighted | 5    | -0.06475 | 0.187912 | 0.730396 | 0.998683795 | -0.43306 | 0.303554 | 0.937298 | 0.648519788 | 1.354664831 |
| GCST005211-Nodular sclerosis Hodgkin lymphoma                                                                                                                                         | Inverse variance weighted | 4    | 0.031981 | 0.092911 | 0.730686 | 0.998683795 | -0.15012 | 0.214087 | 1.032498 | 0.86060084  | 1.238730325 |
| GCST007928-Medication use (diuretics)                                                                                                                                                 | Inverse variance weighted | 54   | -0.0128  | 0.037205 | 0.730773 | 0.998683795 | -0.08572 | 0.060119 | 0.98728  | 0.917847986 | 1.061963281 |
| GCST003194-Fibrinogen levels                                                                                                                                                          | Inverse variance weighted | 26   | 0.132698 | 0.386489 | 0.731341 | 0.998683795 | -0.62482 | 0.890216 | 1.141905 | 0.535357706 | 2.435656849 |
| GCST006230-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 3    | -0.0166  | 0.04851  | 0.732163 | 0.998683795 | -0.11168 | 0.078477 | 0.983534 | 0.894327982 | 1.081639016 |
| GCST005171-QT interval                                                                                                                                                                | Inverse variance weighted | 8    | -0.00234 | 0.006845 | 0.732422 | 0.998683795 | -0.01576 | 0.011076 | 0.997662 | 0.984366856 | 1.011137482 |
| GCST002351-Chronic obstructive pulmonary disease (moderate to severe)                                                                                                                 | Inverse variance weighted | 2    | -0.01547 | 0.04555  | 0.734072 | 0.998683795 | -0.10475 | 0.073803 | 0.984645 | 0.900548693 | 1.076595121 |
| GCST003125-Influenza A (H1N1) infection                                                                                                                                               | Inverse variance weighted | 4    | 0.005213 | 0.015358 | 0.734306 | 0.998683795 | -0.02489 | 0.035314 | 1.005226 | 0.975417915 | 1.035945377 |
| GCST001207-Butyrylcholinesterase levels                                                                                                                                               | Inverse variance weighted | 3    | -0.00891 | 0.0263   | 0.734782 | 0.998683795 | -0.06046 | 0.042638 | 0.99113  | 0.941333818 | 1.043560238 |
| GCST004615-Hemoglobin concentration                                                                                                                                                   | Inverse variance weighted | 64   | 0.02488  | 0.073643 | 0.735483 | 0.998683795 | -0.11946 | 0.169219 | 1.025192 | 0.88739917  | 1.184380049 |
| GCST004419-Mucinous ovarian carcinoma                                                                                                                                                 | Inverse variance weighted | 2    | 0.018785 | 0.055913 | 0.736895 | 0.998683795 | -0.0908  | 0.128374 | 1.018962 | 0.913196692 | 1.136977898 |
| GCST005781-Total cholesterol levels                                                                                                                                                   | Inverse variance weighted | 2    | 0.003888 | 0.011598 | 0.737451 | 0.998683795 | -0.01884 | 0.026619 | 1.003895 | 0.981333155 | 1.026976387 |
| GCST001670-Vitiligo                                                                                                                                                                   | Inverse variance weighted | 2    | -0.02304 | 0.069562 | 0.740497 | 0.998683795 | -0.15938 | 0.113303 | 0.977225 | 0.852672537 | 1.119970838 |
| GCST001571-Age-related macular degeneration                                                                                                                                           | Inverse variance weighted | 3    | -0.00413 | 0.012492 | 0.741024 | 0.998683795 | -0.02861 | 0.020356 | 0.99588  | 0.97179174  | 1.020564973 |
| GCST008058-Estimated glomerular filtration rate                                                                                                                                       | Inverse variance weighted | 169  | 0.168861 | 0.511404 | 0.741255 | 0.998683795 | -0.83349 | 1.171213 | 1.183956 | 0.434530267 | 3.225901736 |
| GCST003367-circulating leptin levels                                                                                                                                                  | Inverse variance weighted | 2    | -0.12044 | 0.364894 | 0.741354 | 0.998683795 | -0.83563 | 0.594755 | 0.886533 | 0.433601213 | 1.812587479 |
| GCST002043-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 4    | -0.09014 | 0.273302 | 0.741541 | 0.998683795 | -0.62581 | 0.445533 | 0.913804 | 0.534827805 | 1.561322419 |
| GCST001718-Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma)                                                                                                | Inverse variance weighted | 2    | 0.035915 | 0.109388 | 0.742661 | 0.998683795 | -0.17848 | 0.250315 | 1.036568 | 0.836537121 | 1.28443011  |
| GCST002044-Triglycerides                                                                                                                                                              | Inverse variance weighted | 4    | 0.042161 | 0.128634 | 0.743094 | 0.998683795 | -0.20996 | 0.294283 | 1.043062 | 0.810615598 | 1.342163936 |
| GCST006626-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 22   | 0.008686 | 0.026532 | 0.743369 | 0.998683795 | -0.04332 | 0.060689 | 1.008724 | 0.957608806 | 1.062568067 |
| GCST001965-Glycemic traits                                                                                                                                                            | Inverse variance weighted | 2    | 0.02264  | 0.069388 | 0.744209 | 0.998683795 | -0.11336 | 0.15864  | 1.022898 | 0.892829449 | 1.171915936 |
| GCST005787-Heart rate response to exercise                                                                                                                                            | Inverse variance weighted | 15   | 0.003116 | 0.009584 | 0.745124 | 0.998683795 | -0.01567 | 0.0219   | 1.00312  | 0.984452855 | 1.022141952 |
| GCST004342-Vaccenic acid (18:1n-7) levels                                                                                                                                             | Inverse variance weighted | 2    | 0.327802 | 1.009641 | 0.745429 | 0.998683795 | -1.65109 | 2.306699 | 1.387915 | 0.191839808 | 10.04122881 |
| GCST004008-Red blood cell count                                                                                                                                                       | Inverse variance weighted | 2    | 0.516329 | 1.590589 | 0.745473 | 0.998683795 | -2.60123 | 3.633884 | 1.675864 | 0.074182567 | 37.8595834  |
| GCST003378-Response to lithium treatment in bipolar disorder                                                                                                                          | Inverse variance weighted | 2    | 0.007042 | 0.021746 | 0.746069 | 0.998683795 | -0.03558 | 0.049664 | 1.007067 | 0.965045701 | 1.050917442 |
| GCST004622-Reticulocyte count                                                                                                                                                         | Inverse variance weighted | 96   | 0.020408 | 0.063287 | 0.747098 | 0.998683795 | -0.10363 | 0.144451 | 1.020618 | 0.901554712 | 1.155404641 |
| GCST006143-Bone mineral density (total hip)                                                                                                                                           | Inverse variance weighted | 2    | -0.02084 | 0.064713 | 0.747386 | 0.998683795 | -0.14768 | 0.105993 | 0.979373 | 0.862707282 | 1.111814647 |
| GCST007943-Medication use (antihistamines for systemic use)                                                                                                                           | Inverse variance weighted | 6    | -0.02704 | 0.084043 | 0.747676 | 0.998683795 | -0.19176 | 0.137687 | 0.973325 | 0.825503548 | 1.147616831 |
| GCST004610-White blood cell count                                                                                                                                                     | Inverse variance weighted | 74   | 0.026547 | 0.082644 | 0.748045 | 0.998683795 | -0.13544 | 0.188529 | 1.026902 | 0.873335546 | 1.207472105 |
| GCST000221-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 3    | 0.017498 | 0.054522 | 0.748265 | 0.998683795 | -0.08937 | 0.12436  | 1.017652 | 0.914511519 | 1.132423937 |
| GCST000028-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 3    | 0.023073 | 0.072576 | 0.750551 | 0.998683795 | -0.11918 | 0.165322 | 1.023341 | 0.887651105 | 1.179773377 |
| GCST008076-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 11   | 0.062043 | 0.195244 | 0.75066  | 0.998683795 | -0.32064 | 0.444721 | 1.064008 | 0.725687589 | 1.560054564 |
| GCST005827-Estrone levels                                                                                                                                                             | Inverse variance weighted | 3    | 0.002444 | 0.007698 | 0.7509   | 0.998683795 | -0.01264 | 0.017532 | 1.002447 | 0.987435266 | 1.017686437 |
| GCST001932-Hair color                                                                                                                                                                 | Inverse variance weighted | 4    | 0.012242 | 0.038577 | 0.750988 | 0.998683795 | -0.06337 | 0.087852 | 1.012317 | 0.938597638 | 1.091826491 |
| GCST000650-Systemic sclerosis                                                                                                                                                         | Inverse variance weighted | 2    | -0.01511 | 0.047802 | 0.751888 | 0.998683795 | -0.10881 | 0.07858  | 0.985001 | 0.89690512  | 1.081749586 |
| GCST003021-Brown vs. non-brown hair color                                                                                                                                             | Inverse variance weighted | 3    | 0.009605 | 0.030446 | 0.752391 | 0.998683795 | -0.05007 | 0.06928  | 1.009652 | 0.951163741 | 1.071736055 |
| GCST003022-Light vs. dark hair color                                                                                                                                                  | Inverse variance weighted | 3    | 0.008013 | 0.025442 | 0.752794 | 0.998683795 | -0.04185 | 0.05788  | 1.008045 | 0.959010455 | 1.059587458 |
| GCST003721-Migraine without aura                                                                                                                                                      | Inverse variance weighted | 3    | 0.022018 | 0.070166 | 0.753679 | 0.998683795 | -0.11551 | 0.159544 | 1.022262 | 0.890912879 | 1.172975915 |
| GCST007278-Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)                | Inverse variance weighted | 10   | 0.013829 | 0.044089 | 0.753785 | 0.998683795 | -0.07259 | 0.100243 | 1.013925 | 0.929985977 | 1.105439505 |
| GCST005538-Sarcoidosis                                                                                                                                                                | Inverse variance weighted | 5    | -0.01726 | 0.055028 | 0.753793 | 0.998683795 | -0.12511 | 0.090596 | 0.982889 | 0.882396095 | 1.094826537 |
| GCST006409-Allergic rhinitis                                                                                                                                                          | Inverse variance weighted | 21   | -0.02865 | 0.091443 | 0.754043 | 0.998683795 | -0.20788 | 0.150577 | 0.971756 | 0.812306433 | 1.162505343 |
| GCST001251-Pulmonary function                                                                                                                                                         | Inverse variance weighted | 3    | -0.1378  | 0.44171  | 0.755062 | 0.998683795 | -1.00355 | 0.727951 | 0.871272 | 0.366574882 | 2.070832667 |
| GCST000562-PR interval                                                                                                                                                                | Inverse variance weighted | 6    | -0.00093 | 0.00299  | 0.755401 | 0.998683795 | -0.00679 | 0.00493  | 0.999069 | 0.993230211 | 1.004941797 |
| GCST000974-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 4    | 0.021462 | 0.069486 | 0.757429 | 0.998683795 | -0.11473 | 0.157655 | 1.021693 | 0.8916053   | 1.170761902 |
| GCST003973-Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI                                                                                                 | Inverse variance weighted | 2    | -0.00064 | 0.002057 | 0.757457 | 0.998683795 | -0.00467 | 0.003397 | 0.999365 | 0.995343015 | 1.003402901 |
| GCST004604-Hematocrit                                                                                                                                                                 | Inverse variance weighted | 62   | 0.019507 | 0.063512 | 0.758732 | 0.998683795 | -0.10498 | 0.143991 | 1.019699 | 0.900346354 | 1.154873269 |
| GCST002110-Glycemic traits (pregnancy)                                                                                                                                                | Inverse variance weighted | 6    | 0.026365 | 0.08601  | 0.759195 | 0.998683795 | -0.14221 | 0.194946 | 1.026716 | 0.867434784 | 1.215245272 |
| GCST007838-Glycine levels                                                                                                                                                             | Inverse variance weighted | 5    | -0.01493 | 0.048747 | 0.759381 | 0.998683795 | -0.11047 | 0.080613 | 0.98518  | 0.895408764 | 1.083951538 |
| GCST006288-Heel bone mineral density                                                                                                                                                  | Inverse variance weighted | 151  | -0.01289 | 0.042158 | 0.75982  | 0.998683795 | -0.09552 | 0.069741 | 0.987194 | 0.908902419 | 1.072230227 |
| GCST002335-Bone properties (heel)                                                                                                                                                     | Inverse variance weighted | 7    | -0.02492 | 0.0817   | 0.760319 | 0.998683795 | -0.18506 | 0.135209 | 0.975384 | 0.831057981 | 1.144775509 |
| GCST007103-QRS duration                                                                                                                                                               | Inverse variance weighted | 18   | 0.002758 | 0.009075 | 0.761207 | 0.998683795 | -0.01503 | 0.020545 | 1.002762 | 0.985083367 | 1.020757151 |
| GCST004351-Bone ultrasound measurement (broadband ultrasound attenuation)                                                                                                             | Inverse variance weighted | 4    | 0.025035 | 0.082547 | 0.76167  | 0.998683795 | -0.13676 | 0.186827 | 1.025351 | 0.872183124 | 1.205418405 |
| GCST006701-Parental longevity (father's attained age)                                                                                                                                 | Inverse variance weighted | 6    | 0.168792 | 0.562072 | 0.763945 | 0.998683795 | -0.93287 | 1.270453 | 1.183874 | 0.393423881 | 3.562464687 |
| GCST002539-Schizophrenia                                                                                                                                                              | Inverse variance weighted | 55   | -0.01237 | 0.041311 | 0.764538 | 0.998683795 | -0.09334 | 0.068596 | 0.987702 | 0.910879943 | 1.071003914 |
| GCST007721-Urinary potassium to creatinine ratio                                                                                                                                      | Inverse variance weighted | 3    | 0.119369 | 0.398897 | 0.764751 | 0.998683795 | -0.66247 | 0.901208 | 1.126786 | 0.515576608 | 2.462576376 |
| GCST008161-Waist circumference adjusted for body mass index                                                                                                                           | Inverse variance weighted | 3    | 0.075716 | 0.253692 | 0.765354 | 0.998683795 | -0.42152 | 0.572952 | 1.078657 | 0.656049056 | 1.77349543  |
| GCST007554-Autism and educational attainment (MTAG)                                                                                                                                   | Inverse variance weighted | 3    | -0.08065 | 0.271131 | 0.766117 | 0.998683795 | -0.61207 | 0.450767 | 0.922517 | 0.542229236 | 1.569514789 |
| GCST003403-Vascular endothelial growth factor levels                                                                                                                                  | Inverse variance weighted | 4    | 0.045006 | 0.15147  | 0.766367 | 0.998683795 | -0.25188 | 0.341888 | 1.046035 | 0.777341789 | 1.407602778 |
| GCST007982-Sleep duration                                                                                                                                                             | Inverse variance weighted | 30   | -0.06756 | 0.227715 | 0.766716 | 0.998683795 | -0.51388 | 0.378765 | 0.934675 | 0.598171108 | 1.460479218 |
| GCST008110-Insulinogenic index                                                                                                                                                        | Inverse variance weighted | 3    | -0.08256 | 0.278509 | 0.766909 | 0.998683795 | -0.62843 | 0.463321 | 0.92076  | 0.53342717  | 1.589343862 |
| GCST003944-Hepcidin/ferritin ratio                                                                                                                                                    | Inverse variance weighted | 3    | 0.019783 | 0.066752 | 0.766945 | 0.998683795 | -0.11105 | 0.150616 | 1.01998  | 0.894894296 | 1.162550702 |
| GCST007878-Urea levels                                                                                                                                                                | Inverse variance weighted | 2    | 0.04874  | 0.165428 | 0.768277 | 0.998683795 | -0.2755  | 0.372979 | 1.049947 | 0.759192953 | 1.452054005 |
| GCST000463-Acute lymphoblastic leukemia (childhood)                                                                                                                                   | Inverse variance weighted | 2    | -0.01017 | 0.034551 | 0.768418 | 0.998683795 | -0.07789 | 0.057546 | 0.989878 | 0.925063672 | 1.059234157 |
| GCST002580-Intraocular pressure                                                                                                                                                       | Inverse variance weighted | 8    | 0.010633 | 0.036187 | 0.768873 | 0.998683795 | -0.06029 | 0.081559 | 1.01069  | 0.941489312 | 1.084977382 |
| GCST007581-Carpal tunnel syndrome                                                                                                                                                     | Inverse variance weighted | 6    | -0.02283 | 0.077852 | 0.769311 | 0.998683795 | -0.17542 | 0.129757 | 0.977427 | 0.839103671 | 1.138551774 |
| GCST001199-Iris characteristics                                                                                                                                                       | Inverse variance weighted | 2    | -0.02229 | 0.076027 | 0.769358 | 0.998683795 | -0.17131 | 0.126721 | 0.977954 | 0.842564478 | 1.135099835 |
| GCST000210-Soluble ICAM-1                                                                                                                                                             | Inverse variance weighted | 3    | -0.0002  | 0.000695 | 0.770454 | 0.998683795 | -0.00156 | 0.001159 | 0.999797 | 0.998436745 | 1.001159707 |
| GCST007387-Insomnia symptoms (never/rarely vs. sometimes/usually)                                                                                                                     | Inverse variance weighted | 15   | 0.044162 | 0.151589 | 0.7708   | 0.998683795 | -0.25295 | 0.341276 | 1.045152 | 0.776505587 | 1.406741035 |
| GCST007382-Plasma free amino acid levels (adjusted for twenty other PFAAs)                                                                                                            | Inverse variance weighted | 24   | 0.00449  | 0.015455 | 0.771404 | 0.998683795 | -0.0258  | 0.034781 | 1.0045   | 0.974529037 | 1.035393284 |
| GCST004772-Bone mineral density (paediatric, total body less head)                                                                                                                    | Inverse variance weighted | 5    | 0.025165 | 0.086624 | 0.771432 | 0.998683795 | -0.14462 | 0.194949 | 1.025484 | 0.865351563 | 1.215248444 |
| GCST007638-Glycine levels                                                                                                                                                             | Inverse variance weighted | 13   | -0.01689 | 0.058327 | 0.772173 | 0.998683795 | -0.13121 | 0.097433 | 0.983254 | 0.877034887 | 1.102337894 |
| GCST003770-Neuroticism                                                                                                                                                                | Inverse variance weighted | 5    | 0.097866 | 0.34343  | 0.77567  | 0.998683795 | -0.57526 | 0.770989 | 1.102815 | 0.562560633 | 2.161902282 |
| GCST004015-Extraversion                                                                                                                                                               | Inverse variance weighted | 3    | -0.12637 | 0.443762 | 0.775827 | 0.998683795 | -0.99614 | 0.743408 | 0.881292 | 0.369302199 | 2.103090028 |
| GCST003972-Visceral adipose tissue/subcutaneous adipose tissue ratio                                                                                                                  | Inverse variance weighted | 2    | -0.00055 | 0.001933 | 0.776103 | 0.998683795 | -0.00434 | 0.003239 | 0.99945  | 0.995671138 | 1.003244059 |
| GCST007157-Corneal astigmatism                                                                                                                                                        | Inverse variance weighted | 2    | 0.048889 | 0.17212  | 0.776378 | 0.998683795 | -0.28847 | 0.386244 | 1.050104 | 0.749412698 | 1.471443926 |
| GCST001220-Metabolite levels                                                                                                                                                          | Inverse variance weighted | 2    | 0.004836 | 0.017267 | 0.779429 | 0.998683795 | -0.02901 | 0.038678 | 1.004847 | 0.971409958 | 1.039435876 |
| GCST000959-Parkinson's disease                                                                                                                                                        | Inverse variance weighted | 6    | -0.02095 | 0.075553 | 0.781558 | 0.998683795 | -0.16903 | 0.127135 | 0.979268 | 0.844479472 | 1.135569785 |
| GCST007341-Well-being spectrum (multivariate analysis)                                                                                                                                | Inverse variance weighted | 152  | 0.063889 | 0.230688 | 0.781818 | 0.998683795 | -0.38826 | 0.516039 | 1.065974 | 0.678235987 | 1.675377757 |
| GCST002331-Basal cell carcinoma                                                                                                                                                       | Inverse variance weighted | 6    | -0.01446 | 0.052225 | 0.781885 | 0.998683795 | -0.11682 | 0.087902 | 0.985645 | 0.889745436 | 1.091880623 |
| GCST005306-Atrial fibrillation                                                                                                                                                        | Inverse variance weighted | 5    | 0.019235 | 0.069645 | 0.782408 | 0.998683795 | -0.11727 | 0.155738 | 1.019421 | 0.889346001 | 1.168520255 |
| GCST004613-Sum neutrophil eosinophil counts                                                                                                                                           | Inverse variance weighted | 68   | 0.023564 | 0.08535  | 0.782483 | 0.998683795 | -0.14372 | 0.190851 | 1.023844 | 0.866127661 | 1.210278968 |
| GCST002033-Malaria                                                                                                                                                                    | Inverse variance weighted | 2    | -0.00789 | 0.028794 | 0.784093 | 0.998683795 | -0.06433 | 0.048547 | 0.992142 | 0.937699111 | 1.049745209 |
| GCST002811-Nonsyndromic cleft lip with or without cleft palate                                                                                                                        | Inverse variance weighted | 4    | -0.00968 | 0.035323 | 0.784136 | 0.998683795 | -0.07891 | 0.059556 | 0.990371 | 0.924124388 | 1.061365722 |
| GCST005014-Tonsillectomy                                                                                                                                                              | Inverse variance weighted | 15   | -0.0197  | 0.072123 | 0.784704 | 0.998683795 | -0.16107 | 0.121658 | 0.980489 | 0.851236629 | 1.129367653 |
| GCST000975-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 3    | -0.02267 | 0.083067 | 0.784918 | 0.998683795 | -0.18548 | 0.140141 | 0.977585 | 0.830704219 | 1.150435876 |
| GCST004430-Interleukin-16 levels                                                                                                                                                      | Inverse variance weighted | 3    | -0.00945 | 0.034657 | 0.78515  | 0.998683795 | -0.07738 | 0.05848  | 0.990596 | 0.925541542 | 1.060223941 |
| GCST006920-Regular attendance at a gym or sports club                                                                                                                                 | Inverse variance weighted | 4    | 0.417114 | 1.531488 | 0.785346 | 0.998683795 | -2.5846  | 3.418831 | 1.517576 | 0.075426085 | 30.53369586 |
| GCST001905-Hypertriglyceridemia                                                                                                                                                       | Inverse variance weighted | 2    | -0.00822 | 0.030214 | 0.785665 | 0.998683795 | -0.06744 | 0.051004 | 0.991817 | 0.934786586 | 1.052326807 |
| GCST001785-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 3    | -0.00898 | 0.033238 | 0.787002 | 0.998683795 | -0.07413 | 0.056166 | 0.991059 | 0.928552839 | 1.057772969 |
| GCST007002-Cerebrospinal fluid t-tau levels in normal cognition                                                                                                                       | Inverse variance weighted | 2    | 0.006935 | 0.025678 | 0.787087 | 0.998683795 | -0.04339 | 0.057264 | 1.00696  | 0.957535185 | 1.058934941 |
| GCST005109-Progranulin levels                                                                                                                                                         | Inverse variance weighted | 2    | -0.07244 | 0.268217 | 0.787111 | 0.998683795 | -0.59814 | 0.453269 | 0.930126 | 0.549832888 | 1.573448025 |
| GCST007353-Generalized epilepsy                                                                                                                                                       | Inverse variance weighted | 6    | 0.00031  | 0.00115  | 0.787271 | 0.998683795 | -0.00194 | 0.002564 | 1.00031  | 0.998058842 | 1.002566802 |
| GCST004348-Non-glioblastoma glioma                                                                                                                                                    | Inverse variance weighted | 7    | -0.011   | 0.040931 | 0.788102 | 0.998683795 | -0.09123 | 0.069223 | 0.989059 | 0.912812031 | 1.071675089 |
| GCST002671-Toenail selenium levels                                                                                                                                                    | Inverse variance weighted | 3    | 0.092736 | 0.345136 | 0.788164 | 0.998683795 | -0.58373 | 0.769204 | 1.097173 | 0.557813296 | 2.158047643 |
| GCST003184-Atopic dermatitis                                                                                                                                                          | Inverse variance weighted | 6    | 0.023249 | 0.086527 | 0.788169 | 0.998683795 | -0.14634 | 0.192841 | 1.023521 | 0.863860877 | 1.212690011 |
| GCST004886-Alcohol consumption                                                                                                                                                        | Inverse variance weighted | 5    | -0.12149 | 0.452447 | 0.788303 | 0.998683795 | -1.00828 | 0.765307 | 0.885601 | 0.364844394 | 2.149653435 |
| GCST004063-Waist circumference adjusted for body mass index                                                                                                                           | Inverse variance weighted | 57   | -0.02408 | 0.090322 | 0.789792 | 0.998683795 | -0.20111 | 0.152953 | 0.976209 | 0.817822853 | 1.165270462 |
| GCST000495-Bone mineral density (hip)                                                                                                                                                 | Inverse variance weighted | 5    | -0.02455 | 0.092239 | 0.790159 | 0.998683795 | -0.20533 | 0.156243 | 0.975754 | 0.814375374 | 1.16911073  |
| GCST001792-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 3    | 0.02344  | 0.088707 | 0.791591 | 0.998683795 | -0.15043 | 0.197306 | 1.023717 | 0.860341896 | 1.218116986 |
| GCST000830-Body mass index                                                                                                                                                            | Inverse variance weighted | 23   | -0.0119  | 0.04508  | 0.791765 | 0.998683795 | -0.10026 | 0.076454 | 0.988169 | 0.904603777 | 1.079452976 |
| GCST004824-P wave terminal force                                                                                                                                                      | Inverse variance weighted | 6    | 1.62E-05 | 6.2E-05  | 0.794309 | 0.998683795 | -0.00011 | 0.000138 | 1.000016 | 0.999894583 | 1.000137782 |
| GCST007402-Factor VII activity or levels                                                                                                                                              | Inverse variance weighted | 3    | -0.43083 | 1.655016 | 0.794617 | 0.998683795 | -3.67467 | 2.812997 | 0.649967 | 0.025357891 | 16.65976492 |
| GCST002056-Osteosarcoma                                                                                                                                                               | Inverse variance weighted | 2    | -0.02402 | 0.092287 | 0.794627 | 0.998683795 | -0.2049  | 0.156859 | 0.976263 | 0.814724991 | 1.1698305   |
| GCST006463-Urinary albumin excretion (no hypertensive medication)                                                                                                                     | Inverse variance weighted | 12   | 0.108916 | 0.418546 | 0.79469  | 0.998683795 | -0.71143 | 0.929266 | 1.115069 | 0.490939568 | 2.532650454 |
| GCST004429-Stem cell factor levels                                                                                                                                                    | Inverse variance weighted | 2    | 0.065828 | 0.25314  | 0.794828 | 0.998683795 | -0.43033 | 0.561984 | 1.068043 | 0.650296402 | 1.754148729 |
| GCST000532-Beta thalassemia/hemoglobin E disease                                                                                                                                      | Inverse variance weighted | 2    | -0.00328 | 0.012705 | 0.796371 | 0.998683795 | -0.02818 | 0.021623 | 0.996727 | 0.972213785 | 1.021858237 |
| GCST001876-Pubertal anthropometrics                                                                                                                                                   | Inverse variance weighted | 2    | -0.0314  | 0.122593 | 0.797854 | 0.998683795 | -0.27168 | 0.208884 | 0.969089 | 0.762096309 | 1.232301759 |
| GCST005080-PR interval                                                                                                                                                                | Inverse variance weighted | 7    | 0.000653 | 0.002549 | 0.797859 | 0.998683795 | -0.00434 | 0.005649 | 1.000653 | 0.995666351 | 1.005664703 |
| GCST000538-Adiponectin levels                                                                                                                                                         | Inverse variance weighted | 3    | 0.005446 | 0.02128  | 0.798012 | 0.998683795 | -0.03626 | 0.047154 | 1.005461 | 0.96438741  | 1.048283421 |
| GCST004632-Lymphocyte percentage of white cells                                                                                                                                       | Inverse variance weighted | 58   | -0.02126 | 0.083204 | 0.798288 | 0.998683795 | -0.18434 | 0.141816 | 0.978961 | 0.831649604 | 1.152364837 |
| GCST007703-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 69   | -0.00103 | 0.004055 | 0.798647 | 0.998683795 | -0.00898 | 0.006914 | 0.998966 | 0.991057573 | 1.006937657 |
| GCST001006-Waist Circumference - Triglycerides (WC-TG)                                                                                                                                | Inverse variance weighted | 5    | 0.009873 | 0.03889  | 0.799595 | 0.998683795 | -0.06635 | 0.086097 | 1.009922 | 0.935802169 | 1.089912288 |
| GCST004259-Mean arterial pressure (long-term average)                                                                                                                                 | Inverse variance weighted | 3    | -0.0059  | 0.02336  | 0.800562 | 0.998683795 | -0.05169 | 0.039884 | 0.994116 | 0.94962715  | 1.040689714 |
| GCST005952-Body mass index (age>50)                                                                                                                                                   | Inverse variance weighted | 5    | 0.069029 | 0.275169 | 0.80192  | 0.998683795 | -0.4703  | 0.60836  | 1.071468 | 0.624814255 | 1.837415099 |
| GCST002483-Lung function (forced vital capacity)                                                                                                                                      | Inverse variance weighted | 4    | 0.000104 | 0.000417 | 0.802518 | 0.998683795 | -0.00071 | 0.000921 | 1.000104 | 0.999287891 | 1.000921165 |
| GCST005328-Subjective well-being                                                                                                                                                      | Inverse variance weighted | 8    | 0.104986 | 0.42018  | 0.802696 | 0.998683795 | -0.71857 | 0.92854  | 1.110695 | 0.487449999 | 2.53081047  |
| GCST003401-Glomerular filtration rate in non diabetics (creatinine)                                                                                                                   | Inverse variance weighted | 25   | 0.107918 | 0.431943 | 0.802708 | 0.998683795 | -0.73869 | 0.954527 | 1.113957 | 0.477739286 | 2.597441025 |
| GCST008281-Hip bone size                                                                                                                                                              | Inverse variance weighted | 5    | -0.03285 | 0.131814 | 0.803202 | 0.998683795 | -0.2912  | 0.225506 | 0.967685 | 0.747363289 | 1.252957046 |
| GCST005776-High density lipoprotein cholesterol levels                                                                                                                                | Inverse variance weighted | 6    | 0.000722 | 0.002915 | 0.804475 | 0.998683795 | -0.00499 | 0.006436 | 1.000722 | 0.995019998 | 1.006456665 |
| GCST007159-Corneal astigmatism                                                                                                                                                        | Inverse variance weighted | 2    | -0.13296 | 0.537993 | 0.804798 | 0.998683795 | -1.18743 | 0.921506 | 0.8755   | 0.305004952 | 2.513072284 |
| GCST002542-Electrocardiographic traits                                                                                                                                                | Inverse variance weighted | 2    | -0.00112 | 0.004555 | 0.806582 | 0.998683795 | -0.01004 | 0.007812 | 0.998885 | 0.990007862 | 1.007842657 |
| GCST004482-Peripheral arterial disease (traffic-related air pollution interaction)                                                                                                    | Inverse variance weighted | 3    | -0.00108 | 0.004426 | 0.806615 | 0.998683795 | -0.00976 | 0.007591 | 0.998917 | 0.990289095 | 1.007620338 |
| GCST001200-Graves' disease                                                                                                                                                            | Inverse variance weighted | 2    | -0.01838 | 0.075221 | 0.806921 | 0.998683795 | -0.16582 | 0.129049 | 0.981784 | 0.847201033 | 1.137746093 |
| GCST005350-Total body bone mineral density (age 45-60)                                                                                                                                | Inverse variance weighted | 10   | -0.01601 | 0.065823 | 0.807838 | 0.998683795 | -0.14502 | 0.113004 | 0.984118 | 0.865003282 | 1.119636063 |
| GCST006717-Alcohol use disorder (dependence and problematic use scores)                                                                                                               | Inverse variance weighted | 2    | 1.197688 | 4.931302 | 0.808103 | 0.998683795 | -8.46766 | 10.86304 | 3.312449 | 0.000210155 | 52210.55653 |
| GCST008087-Triglyceride levels in current drinkers                                                                                                                                    | Inverse variance weighted | 15   | 0.038553 | 0.159691 | 0.80923  | 0.998683795 | -0.27444 | 0.351548 | 1.039305 | 0.759995818 | 1.421265326 |
| GCST004571-Iron status biomarkers (total iron binding capacity)                                                                                                                       | Inverse variance weighted | 2    | 0.012807 | 0.053174 | 0.809674 | 0.998683795 | -0.09141 | 0.117027 | 1.012889 | 0.912639995 | 1.124150095 |
| GCST001147-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 6    | 0.018381 | 0.076425 | 0.809936 | 0.998683795 | -0.13141 | 0.168174 | 1.018551 | 0.876856217 | 1.183142439 |
| GCST000396-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 3    | -0.00855 | 0.035614 | 0.810168 | 0.998683795 | -0.07836 | 0.061249 | 0.991482 | 0.924632127 | 1.063164073 |
| GCST007706-Mean arterial pressure                                                                                                                                                     | Inverse variance weighted | 69   | -0.00139 | 0.005814 | 0.810551 | 0.998683795 | -0.01279 | 0.010003 | 0.998607 | 0.987291251 | 1.010052749 |
| GCST002652-Cotinine glucuronidation                                                                                                                                                   | Inverse variance weighted | 2    | -0.16384 | 0.68401  | 0.8107   | 0.998683795 | -1.5045  | 1.176823 | 0.848881 | 0.222129313 | 3.244050596 |
| GCST005958-Waist-to-hip ratio adjusted for BMI (age >50)                                                                                                                              | Inverse variance weighted | 5    | -0.07899 | 0.330749 | 0.811235 | 0.998683795 | -0.72726 | 0.569274 | 0.924046 | 0.483230357 | 1.766984015 |
| GCST002457-P wave duration                                                                                                                                                            | Inverse variance weighted | 2    | 0.002329 | 0.009794 | 0.812063 | 0.998683795 | -0.01687 | 0.021526 | 1.002331 | 0.983273279 | 1.021759071 |
| GCST000588-Red blood cell count                                                                                                                                                       | Inverse variance weighted | 6    | -0.03274 | 0.138203 | 0.812717 | 0.998683795 | -0.30362 | 0.238134 | 0.967787 | 0.738140749 | 1.268879339 |
| GCST002497-Blood pressure                                                                                                                                                             | Inverse variance weighted | 3    | 0.002305 | 0.009737 | 0.812874 | 0.998683795 | -0.01678 | 0.021389 | 1.002308 | 0.983360512 | 1.02161972  |
| GCST007460-Smoking cessation                                                                                                                                                          | Inverse variance weighted | 13   | -0.04907 | 0.207476 | 0.813045 | 0.998683795 | -0.45572 | 0.357585 | 0.952117 | 0.633990819 | 1.429872176 |
| GCST006483-Lung function (FVC)                                                                                                                                                        | Inverse variance weighted | 13   | -5.9E-05 | 0.000249 | 0.813573 | 0.998683795 | -0.00055 | 0.00043  | 0.999941 | 0.999452507 | 1.000430107 |
| GCST000262-Intracranial aneurysm                                                                                                                                                      | Inverse variance weighted | 3    | -0.00949 | 0.040418 | 0.814402 | 0.998683795 | -0.08871 | 0.069731 | 0.990557 | 0.915113168 | 1.072219907 |
| GCST004185-Lung function (FEV1/FVC)                                                                                                                                                   | Inverse variance weighted | 19   | 0.030259 | 0.130315 | 0.816386 | 0.998683795 | -0.22516 | 0.285676 | 1.030721 | 0.798389146 | 1.330661602 |
| GCST005524-Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis)                                                                                                    | Inverse variance weighted | 3    | 0.007923 | 0.034314 | 0.817382 | 0.998683795 | -0.05933 | 0.075178 | 1.007955 | 0.942394486 | 1.078076337 |
| GCST004986-Idiopathic pulmonary fibrosis                                                                                                                                              | Inverse variance weighted | 2    | -0.03645 | 0.15846  | 0.818068 | 0.998683795 | -0.34703 | 0.27413  | 0.964206 | 0.706783176 | 1.315385964 |
| GCST005582-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 2    | 0.015861 | 0.06906  | 0.818349 | 0.998683795 | -0.1195  | 0.151219 | 1.015987 | 0.887366338 | 1.163251896 |
| GCST007935-Medication use (drugs affecting bone structure and mineralization)                                                                                                         | Inverse variance weighted | 5    | -0.0158  | 0.068858 | 0.818499 | 0.998683795 | -0.15076 | 0.119161 | 0.984323 | 0.860051396 | 1.126550858 |
| GCST007131-Low density lipoprotein cholesterol levels                                                                                                                                 | Inverse variance weighted | 6    | -0.1143  | 0.500339 | 0.819293 | 0.998683795 | -1.09497 | 0.866359 | 0.891986 | 0.334549971 | 2.378236852 |
| GCST007045-PR interval                                                                                                                                                                | Inverse variance weighted | 27   | 0.000555 | 0.002457 | 0.821167 | 0.998683795 | -0.00426 | 0.005372 | 1.000556 | 0.995748314 | 1.005386092 |
| GCST002773-Gout                                                                                                                                                                       | Inverse variance weighted | 2    | 0.00673  | 0.030156 | 0.823413 | 0.998683795 | -0.05238 | 0.065836 | 1.006752 | 0.948971031 | 1.068051794 |
| GCST008064-Chronic kidney disease                                                                                                                                                     | Inverse variance weighted | 13   | 0.014101 | 0.063254 | 0.823587 | 0.998683795 | -0.10988 | 0.138079 | 1.014201 | 0.895945177 | 1.148066092 |
| GCST002304-Fractional exhaled nitric oxide (childhood)                                                                                                                                | Inverse variance weighted | 2    | 0.031767 | 0.1425   | 0.823594 | 0.998683795 | -0.24753 | 0.311066 | 1.032277 | 0.780724656 | 1.364879579 |
| GCST000544-Pulmonary function                                                                                                                                                         | Inverse variance weighted | 4    | 0.035995 | 0.161775 | 0.823926 | 0.998683795 | -0.28108 | 0.353074 | 1.03665  | 0.754964434 | 1.423436412 |
| GCST006408-Allergic sensitization                                                                                                                                                     | Inverse variance weighted | 6    | 0.010609 | 0.04778  | 0.824278 | 0.998683795 | -0.08304 | 0.104258 | 1.010666 | 0.920315268 | 1.109886339 |
| GCST007227-QRS duration                                                                                                                                                               | Inverse variance weighted | 8    | -0.00171 | 0.007794 | 0.826144 | 0.998683795 | -0.01699 | 0.013565 | 0.998289 | 0.983154925 | 1.013657011 |
| GCST001049-D-dimer levels                                                                                                                                                             | Inverse variance weighted | 3    | 0.000285 | 0.001307 | 0.827567 | 0.998683795 | -0.00228 | 0.002847 | 1.000285 | 0.997725389 | 1.002850692 |
| GCST007930-Medication use (agents acting on the renin-angiotensin system)                                                                                                             | Inverse variance weighted | 117  | 0.011    | 0.050783 | 0.82851  | 0.998683795 | -0.08853 | 0.110535 | 1.011061 | 0.915271204 | 1.116875968 |
| GCST000240-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 3    | 0.001007 | 0.004648 | 0.828571 | 0.998683795 | -0.0081  | 0.010117 | 1.001007 | 0.991928712 | 1.010168392 |
| GCST000394-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 3    | 0.012159 | 0.056181 | 0.828661 | 0.998683795 | -0.09796 | 0.122274 | 1.012233 | 0.906688353 | 1.130063522 |
| GCST000430-C-reactive protein                                                                                                                                                         | Inverse variance weighted | 4    | -0.00012 | 0.000565 | 0.828737 | 0.998683795 | -0.00123 | 0.000985 | 0.999878 | 0.998771181 | 1.000985625 |
| GCST004787-Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) | Inverse variance weighted | 27   | 0.020786 | 0.096127 | 0.828808 | 0.998683795 | -0.16762 | 0.209196 | 1.021003 | 0.84567172  | 1.232685998 |
| GCST000847-Retinal vascular caliber                                                                                                                                                   | Inverse variance weighted | 3    | 0.002229 | 0.010337 | 0.829246 | 0.998683795 | -0.01803 | 0.02249  | 1.002232 | 0.982130199 | 1.022745009 |
| GCST001137-White blood cell count                                                                                                                                                     | Inverse variance weighted | 5    | -0.08506 | 0.39443  | 0.829268 | 0.998683795 | -0.85814 | 0.688029 | 0.918462 | 0.423950394 | 1.989789131 |
| GCST007857-Fasting blood insulin adjusted for BMI                                                                                                                                     | Inverse variance weighted | 2    | -0.11216 | 0.52151  | 0.829718 | 0.998683795 | -1.13432 | 0.910003 | 0.893904 | 0.321641533 | 2.484329326 |
| GCST002456-PR segment                                                                                                                                                                 | Inverse variance weighted | 7    | 0.000751 | 0.003502 | 0.830088 | 0.998683795 | -0.00611 | 0.007615 | 1.000752 | 0.99390627  | 1.007644408 |
| GCST006899-Thyroid stimulating hormone levels                                                                                                                                         | Inverse variance weighted | 13   | -0.02696 | 0.126654 | 0.831439 | 0.998683795 | -0.2752  | 0.221283 | 0.973401 | 0.759418907 | 1.247676896 |
| GCST000360-Warfarin maintenance dose                                                                                                                                                  | Inverse variance weighted | 2    | -0.00843 | 0.039742 | 0.831985 | 0.998683795 | -0.08633 | 0.069463 | 0.991604 | 0.917295615 | 1.071931887 |
| GCST007472-Alcohol consumption (drinks per week) (MTAG)                                                                                                                               | Inverse variance weighted | 85   | 0.047764 | 0.225405 | 0.832183 | 0.998683795 | -0.39403 | 0.489558 | 1.048923 | 0.674333775 | 1.631595112 |
| GCST000581-Urate levels                                                                                                                                                               | Inverse variance weighted | 4    | 0.019508 | 0.09317  | 0.834148 | 0.998683795 | -0.16311 | 0.202122 | 1.0197   | 0.849501635 | 1.223997634 |
| GCST002078-Migraine without aura                                                                                                                                                      | Inverse variance weighted | 3    | -0.01446 | 0.069653 | 0.835492 | 0.998683795 | -0.15098 | 0.122056 | 0.98564  | 0.859861143 | 1.129816862 |
| GCST000592-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 2    | 0.010927 | 0.053308 | 0.837584 | 0.998683795 | -0.09356 | 0.115411 | 1.010987 | 0.910686898 | 1.122334285 |
| GCST000964-Ulcerative colitis                                                                                                                                                         | Inverse variance weighted | 29   | 0.005784 | 0.028806 | 0.840867 | 0.998683795 | -0.05068 | 0.062243 | 1.005801 | 0.950586741 | 1.06422139  |
| GCST002322-Asthma and hay fever                                                                                                                                                       | Inverse variance weighted | 8    | -0.01631 | 0.081352 | 0.841067 | 0.998683795 | -0.17576 | 0.143137 | 0.983819 | 0.838816164 | 1.153887557 |
| GCST002021-Body mass index                                                                                                                                                            | Inverse variance weighted | 4    | -0.02467 | 0.123131 | 0.841171 | 0.998683795 | -0.26601 | 0.216663 | 0.975627 | 0.766429546 | 1.241925002 |
| GCST000703-Phosphorus levels                                                                                                                                                          | Inverse variance weighted | 3    | 0.09004  | 0.449789 | 0.841337 | 0.998683795 | -0.79155 | 0.971627 | 1.094218 | 0.45314346  | 2.642240409 |
| GCST001103-Alcohol consumption (transferrin glycosylation)                                                                                                                            | Inverse variance weighted | 5    | 0.005189 | 0.026297 | 0.843563 | 0.998683795 | -0.04635 | 0.056731 | 1.005203 | 0.95470526  | 1.058371462 |
| GCST001242-Schizophrenia                                                                                                                                                              | Inverse variance weighted | 5    | 0.007478 | 0.038279 | 0.84512  | 0.998683795 | -0.06755 | 0.082505 | 1.007506 | 0.93468174  | 1.086003745 |
| GCST000296-Body mass index                                                                                                                                                            | Inverse variance weighted | 8    | -0.00031 | 0.001592 | 0.846009 | 0.998683795 | -0.00343 | 0.00281  | 0.999691 | 0.996577343 | 1.002814283 |
| GCST008047-Platelet count                                                                                                                                                             | Inverse variance weighted | 5    | 0.00036  | 0.001867 | 0.847153 | 0.998683795 | -0.0033  | 0.004019 | 1.00036  | 0.996706335 | 1.004026846 |
| GCST000872-QRS duration                                                                                                                                                               | Inverse variance weighted | 6    | 0.002477 | 0.012869 | 0.847379 | 0.998683795 | -0.02275 | 0.0277   | 1.00248  | 0.977510052 | 1.028087612 |
| GCST001316-IgE levels                                                                                                                                                                 | Inverse variance weighted | 4    | 0.021539 | 0.112061 | 0.847577 | 0.998683795 | -0.1981  | 0.241179 | 1.021773 | 0.820287766 | 1.272748319 |
| GCST004093-Prostate-specific antigen levels                                                                                                                                           | Inverse variance weighted | 13   | -0.01405 | 0.07331  | 0.848002 | 0.998683795 | -0.15774 | 0.129636 | 0.986047 | 0.854073069 | 1.138414116 |
| GCST004399-Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms                                                                                                              | Inverse variance weighted | 8    | -0.00077 | 0.004038 | 0.849655 | 0.998683795 | -0.00868 | 0.00715  | 0.999235 | 0.991356615 | 1.00717552  |
| GCST004213-Resting heart rate                                                                                                                                                         | Inverse variance weighted | 2    | 0.003286 | 0.017341 | 0.849696 | 0.998683795 | -0.0307  | 0.037275 | 1.003292 | 0.969764412 | 1.037977971 |
| GCST003154-Peripheral artery disease                                                                                                                                                  | Inverse variance weighted | 2    | -0.02301 | 0.122015 | 0.85039  | 0.998683795 | -0.26216 | 0.216135 | 0.977248 | 0.769384654 | 1.241269828 |
| GCST001885-Height                                                                                                                                                                     | Inverse variance weighted | 2    | 0.027751 | 0.148725 | 0.851982 | 0.998683795 | -0.26375 | 0.319252 | 1.028139 | 0.768164841 | 1.376098621 |
| GCST005788-Heart rate response to recovery post exercise                                                                                                                              | Inverse variance weighted | 14   | -0.00207 | 0.011108 | 0.852002 | 0.998683795 | -0.02384 | 0.019699 | 0.99793  | 0.976438547 | 1.019894154 |
| GCST004614-Granulocyte count                                                                                                                                                          | Inverse variance weighted | 68   | 0.016566 | 0.088932 | 0.85223  | 0.998683795 | -0.15774 | 0.190873 | 1.016704 | 0.854070186 | 1.2103063   |
| GCST004288-Adolescent idiopathic scoliosis                                                                                                                                            | Inverse variance weighted | 4    | -0.00567 | 0.030781 | 0.85382  | 0.998683795 | -0.066   | 0.05466  | 0.994345 | 0.936128122 | 1.056181626 |
| GCST008129-Body mass index                                                                                                                                                            | Inverse variance weighted | 48   | -0.03174 | 0.172678 | 0.85414  | 0.998683795 | -0.37019 | 0.306705 | 0.968754 | 0.690599993 | 1.358939481 |
| GCST007929-Medication use (calcium channel blockers)                                                                                                                                  | Inverse variance weighted | 63   | 0.01151  | 0.063376 | 0.855881 | 0.998683795 | -0.11271 | 0.135728 | 1.011577 | 0.89341212  | 1.145370529 |
| GCST002022-Testicular germ cell tumor                                                                                                                                                 | Inverse variance weighted | 11   | -0.0031  | 0.017144 | 0.856448 | 0.998683795 | -0.0367  | 0.030501 | 0.996903 | 0.963961246 | 1.030971399 |
| GCST002601-Plasma plasminogen levels                                                                                                                                                  | Inverse variance weighted | 2    | -0.0857  | 0.476953 | 0.857405 | 0.998683795 | -1.02053 | 0.849129 | 0.917871 | 0.360405341 | 2.337610809 |
| GCST000367-Homocysteine levels                                                                                                                                                        | Inverse variance weighted | 2    | 0.052682 | 0.296504 | 0.858977 | 0.998683795 | -0.52847 | 0.633829 | 1.054094 | 0.589508888 | 1.884813374 |
| GCST004578-Waist-to-hip ratio adjusted for BMI in active individuals                                                                                                                  | Inverse variance weighted | 25   | 0.015797 | 0.088987 | 0.859102 | 0.998683795 | -0.15862 | 0.190211 | 1.015922 | 0.853322887 | 1.209504241 |
| GCST003769-Depression                                                                                                                                                                 | Inverse variance weighted | 3    | -0.0003  | 0.001718 | 0.859549 | 0.998683795 | -0.00367 | 0.003064 | 0.999696 | 0.996334934 | 1.003068416 |
| GCST007858-Fasting blood glucose adjusted for BMI                                                                                                                                     | Inverse variance weighted | 2    | -0.07454 | 0.426574 | 0.861274 | 0.998683795 | -0.91063 | 0.76154  | 0.928166 | 0.402270603 | 2.141572431 |
| GCST006612-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 58   | 0.018651 | 0.107339 | 0.862052 | 0.998683795 | -0.19173 | 0.229035 | 1.018826 | 0.825527783 | 1.257386331 |
| GCST003622-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 8    | 0.008011 | 0.046361 | 0.862815 | 0.998683795 | -0.08286 | 0.098879 | 1.008043 | 0.920482317 | 1.103932911 |
| GCST000678-Breast cancer                                                                                                                                                              | Inverse variance weighted | 8    | -0.00613 | 0.035526 | 0.863109 | 0.998683795 | -0.07576 | 0.063506 | 0.993893 | 0.927041314 | 1.065566263 |
| GCST008060-Estimated glomerular filtration rate                                                                                                                                       | Inverse variance weighted | 17   | -0.14135 | 0.833328 | 0.865312 | 0.998683795 | -1.77467 | 1.491976 | 0.868189 | 0.169539588 | 4.445872038 |
| GCST003124-Mild influenza (H1N1) infection                                                                                                                                            | Inverse variance weighted | 8    | 0.001704 | 0.010099 | 0.866031 | 0.998683795 | -0.01809 | 0.021497 | 1.001705 | 0.982072578 | 1.021730203 |
| GCST000502-Hematocrit                                                                                                                                                                 | Inverse variance weighted | 7    | 0.005831 | 0.034721 | 0.866636 | 0.998683795 | -0.06222 | 0.073885 | 1.005848 | 0.939673177 | 1.076682888 |
| GCST007992-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 50   | 0.004959 | 0.029604 | 0.866969 | 0.998683795 | -0.05306 | 0.062982 | 1.004971 | 0.94831881  | 1.065008073 |
| GCST000270-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 4    | 0.013547 | 0.080996 | 0.867172 | 0.998683795 | -0.14521 | 0.1723   | 1.013639 | 0.864843923 | 1.188033979 |
| GCST007406-Healthspan                                                                                                                                                                 | Inverse variance weighted | 2    | 0.065058 | 0.389899 | 0.86748  | 0.998683795 | -0.69914 | 0.829259 | 1.067221 | 0.497011235 | 2.29162113  |
| GCST001939-Tanning                                                                                                                                                                    | Inverse variance weighted | 4    | -0.01011 | 0.061528 | 0.869466 | 0.998683795 | -0.13071 | 0.110484 | 0.98994  | 0.877474885 | 1.116818675 |
| GCST007147-Lateral ventricular volume in normal aging                                                                                                                                 | Inverse variance weighted | 4    | 0.000316 | 0.00194  | 0.870781 | 0.998683795 | -0.00349 | 0.004118 | 1.000316 | 0.996519007 | 1.004126745 |
| GCST007338-Positive affect                                                                                                                                                            | Inverse variance weighted | 120  | 0.033978 | 0.210192 | 0.87158  | 0.998683795 | -0.378   | 0.445955 | 1.034562 | 0.68523148  | 1.561980739 |
| GCST006131-Colorectal cancer                                                                                                                                                          | Inverse variance weighted | 16   | -0.00764 | 0.047332 | 0.871694 | 0.998683795 | -0.10041 | 0.085126 | 0.992385 | 0.904462085 | 1.088854308 |
| GCST006614-Total cholesterol levels                                                                                                                                                   | Inverse variance weighted | 79   | 0.012383 | 0.076908 | 0.872083 | 0.998683795 | -0.13836 | 0.163124 | 1.01246  | 0.870787568 | 1.177182255 |
| GCST001938-Ulcerative colitis                                                                                                                                                         | Inverse variance weighted | 2    | -0.00588 | 0.036977 | 0.873609 | 0.998683795 | -0.07836 | 0.066593 | 0.994135 | 0.924633659 | 1.068860651 |
| GCST003129-Primary biliary cholangitis                                                                                                                                                | Inverse variance weighted | 6    | 0.008594 | 0.05449  | 0.874677 | 0.998683795 | -0.09821 | 0.115395 | 1.008631 | 0.906461727 | 1.122316505 |
| GCST005929-Severity of nausea and vomiting of pregnancy                                                                                                                               | Inverse variance weighted | 4    | -0.02098 | 0.134182 | 0.875725 | 0.998683795 | -0.28398 | 0.242012 | 0.979234 | 0.752780054 | 1.273810065 |
| GCST005668-Delta-5 desaturase activity response to n3-polyunsaturated fat supplement                                                                                                  | Inverse variance weighted | 3    | 0.00419  | 0.026959 | 0.876485 | 0.998683795 | -0.04865 | 0.057029 | 1.004199 | 0.952515759 | 1.058686263 |
| GCST003683-Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy)                                                                                                    | Inverse variance weighted | 2    | -0.01122 | 0.072577 | 0.877149 | 0.998683795 | -0.15347 | 0.131032 | 0.988843 | 0.857726021 | 1.140004248 |
| GCST007702-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 3    | -0.00016 | 0.001012 | 0.877163 | 0.998683795 | -0.00214 | 0.001827 | 0.999844 | 0.997862251 | 1.00182885  |
| GCST007096-Pulse pressure                                                                                                                                                             | Inverse variance weighted | 126  | 0.00133  | 0.00874  | 0.879025 | 0.998683795 | -0.0158  | 0.018461 | 1.001331 | 0.984323869 | 1.018632335 |
| GCST002240-Bladder cancer                                                                                                                                                             | Inverse variance weighted | 6    | 0.01395  | 0.091896 | 0.879339 | 0.998683795 | -0.16616 | 0.194066 | 1.014048 | 0.846906646 | 1.214175884 |
| GCST001337-Platelet count                                                                                                                                                             | Inverse variance weighted | 36   | 0.000162 | 0.00107  | 0.879629 | 0.998683795 | -0.00194 | 0.00226  | 1.000162 | 0.998066064 | 1.002262554 |
| GCST000760-Cholesterol, total                                                                                                                                                         | Inverse variance weighted | 32   | -0.00032 | 0.002132 | 0.87979  | 0.998683795 | -0.0045  | 0.003856 | 0.999678 | 0.995508754 | 1.003863908 |
| GCST004618-White blood cell count (basophil)                                                                                                                                          | Inverse variance weighted | 37   | 0.013966 | 0.092497 | 0.879988 | 0.998683795 | -0.16733 | 0.195259 | 1.014063 | 0.845922247 | 1.215625634 |
| GCST005526-Graves' disease                                                                                                                                                            | Inverse variance weighted | 2    | 0.006284 | 0.041652 | 0.880073 | 0.998683795 | -0.07535 | 0.087923 | 1.006304 | 0.927415033 | 1.091903795 |
| GCST001128-Adiposity                                                                                                                                                                  | Inverse variance weighted | 2    | 0.037247 | 0.24706  | 0.880164 | 0.998683795 | -0.44699 | 0.521484 | 1.037949 | 0.639550133 | 1.684526089 |
| GCST007898-Fasting blood insulin                                                                                                                                                      | Inverse variance weighted | 5    | 0.059578 | 0.39558  | 0.880285 | 0.998683795 | -0.71576 | 0.834914 | 1.061388 | 0.488821096 | 2.304616025 |
| GCST003322-Ischemic stroke (large artery atherosclerosis)                                                                                                                             | Inverse variance weighted | 2    | -0.00539 | 0.035831 | 0.880355 | 0.998683795 | -0.07562 | 0.064835 | 0.994621 | 0.927167152 | 1.066982948 |
| GCST004300-Incident atrial fibrillation                                                                                                                                               | Inverse variance weighted | 2    | 0.017016 | 0.113146 | 0.880458 | 0.998683795 | -0.20475 | 0.238783 | 1.017162 | 0.814850146 | 1.269702891 |
| GCST000388-Bilirubin levels                                                                                                                                                           | Inverse variance weighted | 2    | -0.00445 | 0.029608 | 0.88063  | 0.998683795 | -0.06248 | 0.053586 | 0.995564 | 0.939433014 | 1.055047869 |
| GCST001004-Triglycerides-Blood Pressure (TG-BP)                                                                                                                                       | Inverse variance weighted | 6    | -0.00515 | 0.034436 | 0.881142 | 0.998683795 | -0.07264 | 0.062346 | 0.994864 | 0.929931466 | 1.064330991 |
| GCST004785-Vitiligo                                                                                                                                                                   | Inverse variance weighted | 30   | 0.002158 | 0.014602 | 0.882497 | 0.998683795 | -0.02646 | 0.030777 | 1.002161 | 0.97388598  | 1.031255964 |
| GCST007411-Depressive symptoms x dependent stressful life events interaction (2df test)                                                                                               | Inverse variance weighted | 2    | -0.02512 | 0.171358 | 0.88343  | 0.998683795 | -0.36099 | 0.310736 | 0.975188 | 0.696988892 | 1.364428938 |
| GCST008166-Mean corpuscular volume                                                                                                                                                    | Inverse variance weighted | 2    | -0.00303 | 0.020737 | 0.883712 | 0.998683795 | -0.04368 | 0.037611 | 0.996972 | 0.957263387 | 1.03832687  |
| GCST004773-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 8    | -0.02625 | 0.180139 | 0.884163 | 0.998683795 | -0.37932 | 0.326828 | 0.974096 | 0.68432768  | 1.386563175 |
| GCST000042-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 3    | 0.005238 | 0.036561 | 0.88607  | 0.998683795 | -0.06642 | 0.076897 | 1.005252 | 0.935737296 | 1.079931048 |
| GCST008316-Corneal endothelial cell size variation coefficient                                                                                                                        | Inverse variance weighted | 3    | -0.01082 | 0.075796 | 0.886523 | 0.998683795 | -0.15938 | 0.137744 | 0.989242 | 0.852674523 | 1.147682154 |
| GCST004256-Venous thromboembolism                                                                                                                                                     | Inverse variance weighted | 4    | 0.004799 | 0.03387  | 0.887329 | 0.998683795 | -0.06159 | 0.071185 | 1.00481  | 0.940271055 | 1.073779762 |
| GCST004734-Heart rate variability traits (SDNN)                                                                                                                                       | Inverse variance weighted | 10   | -0.02527 | 0.179941 | 0.888323 | 0.998683795 | -0.37795 | 0.327416 | 0.975048 | 0.685262535 | 1.387378949 |
| GCST005906-Endometriosis or endometrial cancer (pleiotropy)                                                                                                                           | Inverse variance weighted | 2    | -0.01062 | 0.07567  | 0.888381 | 0.998683795 | -0.15893 | 0.137693 | 0.989436 | 0.853052217 | 1.147623679 |
| GCST001439-Mean platelet volume                                                                                                                                                       | Inverse variance weighted | 2    | -0.01122 | 0.080005 | 0.888477 | 0.998683795 | -0.16803 | 0.14559  | 0.988844 | 0.845329575 | 1.156722251 |
| GCST001093-C-reactive protein                                                                                                                                                         | Inverse variance weighted | 2    | 0.006278 | 0.04482  | 0.88861  | 0.998683795 | -0.08157 | 0.094125 | 1.006297 | 0.921668832 | 1.098696539 |
| GCST007927-Medication use (beta blocking agents)                                                                                                                                      | Inverse variance weighted | 40   | -0.00636 | 0.045598 | 0.889148 | 0.998683795 | -0.09573 | 0.083017 | 0.993665 | 0.908711014 | 1.086560245 |
| GCST005042-Restless legs syndrome                                                                                                                                                     | Inverse variance weighted | 11   | 0.006257 | 0.045185 | 0.889861 | 0.998683795 | -0.0823  | 0.094819 | 1.006277 | 0.920991249 | 1.099459973 |
| GCST001499-Atrial fibrillation                                                                                                                                                        | Inverse variance weighted | 5    | -0.0064  | 0.046275 | 0.890079 | 0.998683795 | -0.09709 | 0.084303 | 0.993625 | 0.907470573 | 1.087958881 |
| GCST003837-Chronotype                                                                                                                                                                 | Inverse variance weighted | 2    | -0.12215 | 0.885262 | 0.890256 | 0.998683795 | -1.85726 | 1.612966 | 0.885017 | 0.156099402 | 5.017670899 |
| GCST007267-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 194  | 0.000916 | 0.006692 | 0.891161 | 0.998683795 | -0.0122  | 0.014032 | 1.000916 | 0.987873803 | 1.014130579 |
| GCST005902-Depression (broad)                                                                                                                                                         | Inverse variance weighted | 21   | -0.07068 | 0.522595 | 0.892414 | 0.998683795 | -1.09497 | 0.953605 | 0.931759 | 0.334550902 | 2.59504705  |
| GCST007589-Intracranial volume                                                                                                                                                        | Inverse variance weighted | 3    | 0.000404 | 0.002988 | 0.892444 | 0.998683795 | -0.00545 | 0.006261 | 1.000404 | 0.99456212  | 1.006280426 |
| GCST000039-Crohn's disease                                                                                                                                                            | Inverse variance weighted | 2    | -0.01062 | 0.078895 | 0.892876 | 0.998683795 | -0.16526 | 0.144009 | 0.989432 | 0.847675111 | 1.154894606 |
| GCST001074-Blood pressure                                                                                                                                                             | Inverse variance weighted | 6    | -0.00212 | 0.015807 | 0.893532 | 0.998683795 | -0.0331  | 0.028866 | 0.997887 | 0.967444161 | 1.029287123 |
| GCST001877-Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)                              | Inverse variance weighted | 3    | -0.02072 | 0.155471 | 0.89397  | 0.998683795 | -0.32545 | 0.284002 | 0.979492 | 0.722205841 | 1.328435376 |
| GCST002421-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 5    | 0.002978 | 0.022581 | 0.895078 | 0.998683795 | -0.04128 | 0.047236 | 1.002982 | 0.959560184 | 1.048369601 |
| GCST003336-Waist circumference adjusted for body mass index                                                                                                                           | Inverse variance weighted | 3    | -0.04269 | 0.324216 | 0.895249 | 0.998683795 | -0.67815 | 0.592776 | 0.95821  | 0.507554157 | 1.809002942 |
| GCST004505-Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)                                                                                                       | Inverse variance weighted | 29   | 0.01432  | 0.109488 | 0.895944 | 0.998683795 | -0.20028 | 0.228917 | 1.014423 | 0.818503307 | 1.257237691 |
| GCST007922-Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease)                                                                                              | Inverse variance weighted | 3    | -0.02536 | 0.196602 | 0.89735  | 0.998683795 | -0.4107  | 0.359976 | 0.974955 | 0.663183709 | 1.433295384 |
| GCST001781-Mean corpuscular volume                                                                                                                                                    | Inverse variance weighted | 2    | -0.00341 | 0.026659 | 0.898171 | 0.998683795 | -0.05566 | 0.048839 | 0.996594 | 0.945858265 | 1.050051717 |
| GCST000135-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 6    | 0.000501 | 0.003934 | 0.898682 | 0.998683795 | -0.00721 | 0.008212 | 1.000501 | 0.99281616  | 1.008245382 |
| GCST003272-Systolic blood pressure                                                                                                                                                    | Inverse variance weighted | 5    | 0.001332 | 0.010557 | 0.899594 | 0.998683795 | -0.01936 | 0.022023 | 1.001333 | 0.980827007 | 1.022267448 |
| GCST003303-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 4    | -0.01143 | 0.090647 | 0.899687 | 0.998683795 | -0.1891  | 0.166242 | 0.988638 | 0.827707524 | 1.180858736 |
| GCST007344-Estimated glomerular filtration rate                                                                                                                                       | Inverse variance weighted | 61   | -0.00086 | 0.006914 | 0.900551 | 0.998683795 | -0.01442 | 0.012688 | 0.999136 | 0.985687727 | 1.012768464 |
| GCST004500-Waist circumference adjusted for BMI (adjusted for smoking behaviour)                                                                                                      | Inverse variance weighted | 37   | 0.014092 | 0.114255 | 0.901838 | 0.998683795 | -0.20985 | 0.238033 | 1.014192 | 0.810707039 | 1.268750959 |
| GCST006958-Length of menstrual cycle                                                                                                                                                  | Inverse variance weighted | 4    | 0.018729 | 0.153542 | 0.902916 | 0.998683795 | -0.28221 | 0.319672 | 1.018905 | 0.754112561 | 1.376675453 |
| GCST002679-Iron status biomarkers (iron levels)                                                                                                                                       | Inverse variance weighted | 2    | -0.01242 | 0.102393 | 0.903469 | 0.998683795 | -0.21311 | 0.188271 | 0.987659 | 0.808069166 | 1.20716075  |
| GCST000583-Hematological and biochemical traits                                                                                                                                       | Inverse variance weighted | 14   | -0.00471 | 0.039055 | 0.904068 | 0.998683795 | -0.08125 | 0.07184  | 0.995304 | 0.921959427 | 1.074483386 |
| GCST005648-Serum metabolite concentrations in chronic kidney disease                                                                                                                  | Inverse variance weighted | 21   | -0.00147 | 0.012195 | 0.904132 | 0.998683795 | -0.02537 | 0.022433 | 0.998532 | 0.97494893  | 1.02268617  |
| GCST004432-Platelet-derived growth factor BB levels                                                                                                                                   | Inverse variance weighted | 6    | -0.00651 | 0.05413  | 0.90434  | 0.998683795 | -0.1126  | 0.09959  | 0.993516 | 0.893506921 | 1.104718184 |
| GCST003968-Pericardial adipose tissue adjusted for height and weight                                                                                                                  | Inverse variance weighted | 3    | 0.000189 | 0.001582 | 0.904717 | 0.998683795 | -0.00291 | 0.003291 | 1.000189 | 0.997092512 | 1.003295938 |
| GCST003400-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 13   | 0.003707 | 0.031057 | 0.904993 | 0.998683795 | -0.05716 | 0.064578 | 1.003714 | 0.944438536 | 1.066709168 |
| GCST000299-Weight                                                                                                                                                                     | Inverse variance weighted | 8    | 0.000205 | 0.001718 | 0.904999 | 0.998683795 | -0.00316 | 0.003572 | 1.000205 | 0.99684336  | 1.00357802  |
| GCST001248-Pulmonary function                                                                                                                                                         | Inverse variance weighted | 6    | 0.031148 | 0.263228 | 0.905805 | 0.998683795 | -0.48478 | 0.547076 | 1.031638 | 0.615832911 | 1.728192342 |
| GCST003938-Carotenoid levels (alpha-carotene)                                                                                                                                         | Inverse variance weighted | 2    | -0.00753 | 0.063712 | 0.905961 | 0.998683795 | -0.1324  | 0.11735  | 0.992502 | 0.875987849 | 1.124512727 |
| GCST005191-Hair shape                                                                                                                                                                 | Inverse variance weighted | 7    | -0.01457 | 0.127214 | 0.908819 | 0.998683795 | -0.26391 | 0.23477  | 0.985536 | 0.768043539 | 1.264617579 |
| GCST003447-Neuroticism                                                                                                                                                                | Inverse variance weighted | 5    | 0.013383 | 0.117622 | 0.909413 | 0.998683795 | -0.21716 | 0.243922 | 1.013473 | 0.804804449 | 1.276244615 |
| GCST002492-Bone mineral density (paediatric, lower limb)                                                                                                                              | Inverse variance weighted | 2    | -0.02762 | 0.244617 | 0.910092 | 0.998683795 | -0.50707 | 0.451827 | 0.972755 | 0.602256001 | 1.571179989 |
| GCST004029-Angiotensin-converting enzyme inhibitor intolerance                                                                                                                        | Inverse variance weighted | 2    | -0.00345 | 0.030548 | 0.910206 | 0.998683795 | -0.06332 | 0.056428 | 0.996561 | 0.938644328 | 1.058050867 |
| GCST007603-Smoking initiation                                                                                                                                                         | Inverse variance weighted | 26   | -0.03092 | 0.277034 | 0.911136 | 0.998683795 | -0.57391 | 0.512068 | 0.969554 | 0.563320858 | 1.668739165 |
| GCST000144-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 2    | 0.007124 | 0.064517 | 0.912079 | 0.998683795 | -0.11933 | 0.133576 | 1.007149 | 0.887515766 | 1.142908509 |
| GCST001799-Prostate-specific antigen levels                                                                                                                                           | Inverse variance weighted | 2    | -0.02547 | 0.234342 | 0.913455 | 0.998683795 | -0.48478 | 0.433841 | 0.974853 | 0.615833394 | 1.543174205 |
| GCST003275-Mean arterial pressure                                                                                                                                                     | Inverse variance weighted | 6    | -0.00168 | 0.015505 | 0.913667 | 0.998683795 | -0.03207 | 0.028709 | 0.99832  | 0.968437648 | 1.029125276 |
| GCST008277-Corneal hysteresis                                                                                                                                                         | Inverse variance weighted | 3    | -0.00734 | 0.068905 | 0.915223 | 0.998683795 | -0.14239 | 0.127719 | 0.992692 | 0.867283372 | 1.136233837 |
| GCST005649-Urinary metabolite ratios in chronic kidney disease                                                                                                                        | Inverse variance weighted | 2    | -0.00356 | 0.03349  | 0.915455 | 0.998683795 | -0.0692  | 0.062085 | 0.996451 | 0.933144041 | 1.064052897 |
| GCST002890-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 10   | 0.005253 | 0.05005  | 0.916416 | 0.998683795 | -0.09285 | 0.103351 | 1.005267 | 0.911334104 | 1.108880709 |
| GCST004183-Lung function (FEV1)                                                                                                                                                       | Inverse variance weighted | 7    | 0.019126 | 0.182917 | 0.916722 | 0.998683795 | -0.33939 | 0.377644 | 1.019311 | 0.712203875 | 1.458843377 |
| GCST001183-Asthma                                                                                                                                                                     | Inverse variance weighted | 5    | -0.00555 | 0.05372  | 0.917757 | 0.998683795 | -0.11084 | 0.099743 | 0.994468 | 0.895084342 | 1.104887204 |
| GCST002808-Venous thromboembolism                                                                                                                                                     | Inverse variance weighted | 5    | 0.003251 | 0.031514 | 0.917835 | 0.998683795 | -0.05852 | 0.065019 | 1.003256 | 0.94316236  | 1.067179197 |
| GCST002533-QRS duration                                                                                                                                                               | Inverse variance weighted | 3    | 0.001582 | 0.015372 | 0.918021 | 0.998683795 | -0.02855 | 0.031711 | 1.001583 | 0.971857273 | 1.032218773 |
| GCST004232-HDL cholesterol levels                                                                                                                                                     | Inverse variance weighted | 44   | 0.006227 | 0.060649 | 0.918224 | 0.998683795 | -0.11265 | 0.1251   | 1.006246 | 0.893467122 | 1.133261369 |
| GCST001765-Red blood cell traits                                                                                                                                                      | Inverse variance weighted | 31   | 0.002179 | 0.021431 | 0.919023 | 0.998683795 | -0.03983 | 0.044183 | 1.002181 | 0.960957347 | 1.04517333  |
| GCST002625-Chronic bronchitis and chronic obstructive pulmonary disease                                                                                                               | Inverse variance weighted | 2    | 0.003741 | 0.038633 | 0.922851 | 0.998683795 | -0.07198 | 0.079463 | 1.003748 | 0.930549571 | 1.082705108 |
| GCST002712-Red blood cell fatty acid levels                                                                                                                                           | Inverse variance weighted | 5    | -0.00604 | 0.063516 | 0.924261 | 0.998683795 | -0.13053 | 0.118454 | 0.99398  | 0.87762971  | 1.125754791 |
| GCST006881-Hippocampal tail volume (corrected for total hippocampal volume)                                                                                                           | Inverse variance weighted | 7    | 0.000165 | 0.001735 | 0.924325 | 0.998683795 | -0.00324 | 0.003565 | 1.000165 | 0.9967694   | 1.003571801 |
| GCST003239-Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)                                                                                                           | Inverse variance weighted | 2    | -0.03273 | 0.347212 | 0.924888 | 0.998683795 | -0.71327 | 0.647801 | 0.967795 | 0.490038988 | 1.911333644 |
| GCST005348-Total body bone mineral density                                                                                                                                            | Inverse variance weighted | 101  | -0.00344 | 0.036446 | 0.92491  | 0.998683795 | -0.07487 | 0.068    | 0.996571 | 0.927864274 | 1.070364898 |
| GCST002556-White blood cell count                                                                                                                                                     | Inverse variance weighted | 4    | -0.01502 | 0.159559 | 0.924994 | 0.998683795 | -0.32776 | 0.297713 | 0.985091 | 0.720538395 | 1.346775855 |
| GCST005780-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 7    | -0.00011 | 0.001214 | 0.925456 | 0.998683795 | -0.00249 | 0.002267 | 0.999886 | 0.997509345 | 1.002269093 |
| GCST005323-Depressive symptoms (MTAG)                                                                                                                                                 | Inverse variance weighted | 46   | -0.01898 | 0.203549 | 0.92569  | 0.998683795 | -0.41794 | 0.379972 | 0.981194 | 0.658400753 | 1.462243596 |
| GCST004744-Lung adenocarcinoma                                                                                                                                                        | Inverse variance weighted | 14   | -0.00377 | 0.040804 | 0.926363 | 0.998683795 | -0.08375 | 0.076205 | 0.996236 | 0.919663499 | 1.079183807 |
| GCST004428-Stem cell growth factor beta levels                                                                                                                                        | Inverse variance weighted | 3    | 0.005786 | 0.062896 | 0.926698 | 0.998683795 | -0.11749 | 0.129063 | 1.005803 | 0.889149297 | 1.137761882 |
| GCST003327-Squamous cell carcinoma                                                                                                                                                    | Inverse variance weighted | 7    | 0.004121 | 0.04588  | 0.928423 | 0.998683795 | -0.0858  | 0.094046 | 1.00413  | 0.917775005 | 1.098609933 |
| GCST002785-Facial pigmentation                                                                                                                                                        | Inverse variance weighted | 3    | 9.76E-05 | 0.001099 | 0.929247 | 0.998683795 | -0.00206 | 0.002252 | 1.000098 | 0.99794499  | 1.002254891 |
| GCST008259-Alcohol use disorder                                                                                                                                                       | Inverse variance weighted | 9    | -0.0001  | 0.001151 | 0.929363 | 0.998683795 | -0.00236 | 0.002153 | 0.999898 | 0.997645311 | 1.002155769 |
| GCST003374-Chronic kidney disease                                                                                                                                                     | Inverse variance weighted | 3    | 0.005936 | 0.067427 | 0.929844 | 0.998683795 | -0.12622 | 0.138093 | 1.005954 | 0.881420637 | 1.148082309 |
| GCST007226-PR interval                                                                                                                                                                | Inverse variance weighted | 12   | 0.000235 | 0.002694 | 0.930499 | 0.998683795 | -0.00505 | 0.005516 | 1.000235 | 0.994966762 | 1.005531173 |
| GCST004258-Diastolic blood pressure (long-term average)                                                                                                                               | Inverse variance weighted | 3    | -0.00256 | 0.030051 | 0.932187 | 0.998683795 | -0.06146 | 0.056343 | 0.997446 | 0.940393562 | 1.057960004 |
| GCST001605-C-reactive protein and white blood cell count                                                                                                                              | Inverse variance weighted | 6    | 0.003695 | 0.044311 | 0.933551 | 0.998683795 | -0.08316 | 0.090544 | 1.003701 | 0.920208268 | 1.094770079 |
| GCST003061-Cutaneous malignant melanoma                                                                                                                                               | Inverse variance weighted | 5    | -0.00604 | 0.072575 | 0.933619 | 0.998683795 | -0.14829 | 0.136202 | 0.993973 | 0.862179031 | 1.145913771 |
| GCST000483-Folate pathway vitamin levels                                                                                                                                              | Inverse variance weighted | 3    | -0.01014 | 0.122099 | 0.93384  | 0.998683795 | -0.24945 | 0.229178 | 0.989915 | 0.779229377 | 1.257565859 |
| GCST003198-Inguinal hernia                                                                                                                                                            | Inverse variance weighted | 3    | -0.00699 | 0.092574 | 0.939837 | 0.998683795 | -0.18843 | 0.174458 | 0.993037 | 0.828257179 | 1.190600229 |
| GCST001611-Myasthenia gravis                                                                                                                                                          | Inverse variance weighted | 3    | -0.00121 | 0.016163 | 0.940289 | 0.998683795 | -0.03289 | 0.030468 | 0.99879  | 0.967645763 | 1.030936727 |
| GCST000777-Esophageal cancer and gastric cancer                                                                                                                                       | Inverse variance weighted | 3    | 0.003948 | 0.053324 | 0.940974 | 0.998683795 | -0.10057 | 0.108464 | 1.003956 | 0.904324129 | 1.11456518  |
| GCST000444-QT interval                                                                                                                                                                | Inverse variance weighted | 2    | 0.006473 | 0.087755 | 0.941202 | 0.998683795 | -0.16553 | 0.178473 | 1.006494 | 0.84744656  | 1.195390622 |
| GCST006085-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 72   | -0.00185 | 0.025706 | 0.942589 | 0.998683795 | -0.05224 | 0.048533 | 0.99815  | 0.949105475 | 1.049729826 |
| GCST005212-Asthma                                                                                                                                                                     | Inverse variance weighted | 13   | -0.00538 | 0.074878 | 0.942697 | 0.998683795 | -0.15214 | 0.141379 | 0.994632 | 0.858865171 | 1.151860931 |
| GCST008226-Renal cell carcinoma                                                                                                                                                       | Inverse variance weighted | 3    | -0.004   | 0.0571   | 0.944194 | 0.998683795 | -0.11591 | 0.107919 | 0.996011 | 0.890552977 | 1.113957198 |
| GCST008164-Free thyroxine concentration                                                                                                                                               | Inverse variance weighted | 2    | 0.014237 | 0.203771 | 0.944297 | 0.998683795 | -0.38515 | 0.413628 | 1.014339 | 0.680346594 | 1.512294249 |
| GCST001612-Sex hormone-binding globulin levels                                                                                                                                        | Inverse variance weighted | 8    | 0.009751 | 0.143885 | 0.945971 | 0.998683795 | -0.27226 | 0.291765 | 1.009798 | 0.761653333 | 1.338788665 |
| GCST003743-Hypertriglyceridemia                                                                                                                                                       | Inverse variance weighted | 3    | -0.00245 | 0.036292 | 0.946097 | 0.998683795 | -0.07359 | 0.068678 | 0.997549 | 0.929056759 | 1.071091394 |
| GCST007691-Femoral neck bone mineral density                                                                                                                                          | Inverse variance weighted | 18   | -0.0078  | 0.119385 | 0.947918 | 0.998683795 | -0.24179 | 0.226196 | 0.992232 | 0.785219019 | 1.253821133 |
| GCST005166-GIP levels in response to oral glucose tolerance test (120 minutes)                                                                                                        | Inverse variance weighted | 2    | -0.01372 | 0.212616 | 0.948551 | 0.998683795 | -0.43045 | 0.403009 | 0.986374 | 0.650217934 | 1.49632016  |
| GCST007268-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 33   | 0.001093 | 0.017275 | 0.94955  | 0.998683795 | -0.03277 | 0.034952 | 1.001094 | 0.967764883 | 1.035570162 |
| GCST000176-Height                                                                                                                                                                     | Inverse variance weighted | 7    | 0.001242 | 0.020136 | 0.950818 | 0.998683795 | -0.03822 | 0.040709 | 1.001243 | 0.962496517 | 1.041548768 |
| GCST004373-Atrial fibrillation                                                                                                                                                        | Inverse variance weighted | 8    | 0.00198  | 0.032291 | 0.951114 | 0.998683795 | -0.06131 | 0.065271 | 1.001982 | 0.94053016  | 1.067448251 |
| GCST004236-LDL cholesterol levels                                                                                                                                                     | Inverse variance weighted | 5    | -0.00542 | 0.088496 | 0.951127 | 0.998683795 | -0.17888 | 0.168029 | 0.994591 | 0.836208705 | 1.182970663 |
| GCST000366-Fibrinogen                                                                                                                                                                 | Inverse variance weighted | 2    | -0.01129 | 0.190885 | 0.952846 | 0.998683795 | -0.38542 | 0.362848 | 0.988776 | 0.680162751 | 1.437417316 |
| GCST008321-Corneal endothelial cell shape (percentage of hexagonally shaped cells)                                                                                                    | Inverse variance weighted | 2    | 0.004482 | 0.076569 | 0.95332  | 0.998683795 | -0.14559 | 0.154558 | 1.004492 | 0.864508809 | 1.167142201 |
| GCST004557-Body mass index                                                                                                                                                            | Inverse variance weighted | 70   | -0.00455 | 0.080132 | 0.95474  | 0.998683795 | -0.16161 | 0.152512 | 0.995462 | 0.850775165 | 1.164755918 |
| GCST001929-Eye color                                                                                                                                                                  | Inverse variance weighted | 2    | -0.00038 | 0.006814 | 0.955501 | 0.998683795 | -0.01373 | 0.012975 | 0.99962  | 0.986358911 | 1.013059115 |
| GCST004902-Parkinson's disease                                                                                                                                                        | Inverse variance weighted | 28   | -0.00248 | 0.045002 | 0.955989 | 0.998683795 | -0.09069 | 0.085721 | 0.997519 | 0.913302522 | 1.089502221 |
| GCST000132-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 3    | 0.000125 | 0.002287 | 0.956358 | 0.998683795 | -0.00436 | 0.004608 | 1.000125 | 0.99565144  | 1.004619024 |
| GCST001146-Systemic sclerosis                                                                                                                                                         | Inverse variance weighted | 2    | -0.00278 | 0.050983 | 0.956545 | 0.998683795 | -0.10271 | 0.097149 | 0.997226 | 0.902392843 | 1.102024736 |
| GCST000365-Breast cancer                                                                                                                                                              | Inverse variance weighted | 3    | -0.00275 | 0.050961 | 0.956943 | 0.998683795 | -0.10264 | 0.097132 | 0.997252 | 0.902456139 | 1.102006267 |
| GCST002944-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 16   | -0.00112 | 0.020929 | 0.95727  | 0.998683795 | -0.04214 | 0.039899 | 0.998879 | 0.958733719 | 1.040705871 |
| GCST004966-Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease                                                      | Inverse variance weighted | 2    | 0.023161 | 0.432509 | 0.957293 | 0.998683795 | -0.82456 | 0.870878 | 1.023432 | 0.438429784 | 2.389008076 |
| GCST003740-Barrett's esophagus  or Esophageal adenocarcinoma                                                                                                                          | Inverse variance weighted | 5    | -0.00321 | 0.0602   | 0.957435 | 0.998683795 | -0.1212  | 0.114778 | 0.996792 | 0.885852838 | 1.121624793 |
| GCST001407-Ewing sarcoma                                                                                                                                                              | Inverse variance weighted | 3    | 0.001509 | 0.028683 | 0.958051 | 0.998683795 | -0.05471 | 0.057728 | 1.00151  | 0.94675912  | 1.059426806 |
| GCST007553-Autism and major depressive disorder (MTAG)                                                                                                                                | Inverse variance weighted | 4    | 0.011232 | 0.216592 | 0.958641 | 0.998683795 | -0.41329 | 0.435753 | 1.011296 | 0.661471693 | 1.546126209 |
| GCST000167-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 7    | 0.005686 | 0.110233 | 0.958861 | 0.998683795 | -0.21037 | 0.221742 | 1.005702 | 0.810284354 | 1.248249654 |
| GCST007281-HDL cholesterol x physical activity interaction (1df test)                                                                                                                 | Inverse variance weighted | 2    | -0.10089 | 1.98122  | 0.959388 | 0.998683795 | -3.98408 | 3.782304 | 0.904035 | 0.018609597 | 43.91710661 |
| GCST008339-Corneal endothelial cell density                                                                                                                                           | Inverse variance weighted | 4    | -0.00296 | 0.06076  | 0.961121 | 0.998683795 | -0.12205 | 0.116128 | 0.997043 | 0.885102262 | 1.123139992 |
| GCST005953-Body mass index (age <50)                                                                                                                                                  | Inverse variance weighted | 6    | -0.00673 | 0.13889  | 0.961381 | 0.998683795 | -0.27895 | 0.2655   | 0.993297 | 0.756577598 | 1.304082722 |
| GCST003302-Cholesterol, total                                                                                                                                                         | Inverse variance weighted | 4    | -0.00419 | 0.087182 | 0.961627 | 0.998683795 | -0.17507 | 0.166682 | 0.995814 | 0.839397178 | 1.181378802 |
| GCST006102-Interleukin-10 levels                                                                                                                                                      | Inverse variance weighted | 3    | 0.013058 | 0.271515 | 0.961643 | 0.998683795 | -0.51911 | 0.545226 | 1.013143 | 0.595049333 | 1.72499836  |
| GCST007509-Cleft palate                                                                                                                                                               | Inverse variance weighted | 2    | -0.00016 | 0.00338  | 0.96195  | 0.998683795 | -0.00679 | 0.006464 | 0.999839 | 0.993236633 | 1.006484766 |
| GCST007733-Serum uric acid levels                                                                                                                                                     | Inverse variance weighted | 19   | 0.003176 | 0.06739  | 0.962411 | 0.998683795 | -0.12891 | 0.13526  | 1.003181 | 0.879054973 | 1.144834168 |
| GCST007090-Knee osteoarthritis                                                                                                                                                        | Inverse variance weighted | 5    | 0.008255 | 0.175785 | 0.962544 | 0.998683795 | -0.33628 | 0.352793 | 1.008289 | 0.714421123 | 1.423036162 |
| GCST007942-Medication use (glucocorticoids)                                                                                                                                           | Inverse variance weighted | 9    | -0.00283 | 0.063048 | 0.964174 | 0.998683795 | -0.12641 | 0.120742 | 0.997172 | 0.881257489 | 1.128333375 |
| GCST002898-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 22   | -0.00262 | 0.058877 | 0.964484 | 0.998683795 | -0.11802 | 0.112777 | 0.997382 | 0.888677549 | 1.119382823 |
| GCST007240-Obese vs. thin                                                                                                                                                             | Inverse variance weighted | 5    | -0.00245 | 0.055674 | 0.964896 | 0.998683795 | -0.11157 | 0.10667  | 0.997553 | 0.894428502 | 1.112566926 |
| GCST001685-Primary biliary cholangitis                                                                                                                                                | Inverse variance weighted | 4    | -0.00112 | 0.027529 | 0.967669 | 0.998908863 | -0.05507 | 0.05284  | 0.998885 | 0.946417238 | 1.054261104 |
| GCST002701-Verbal declarative memory                                                                                                                                                  | Inverse variance weighted | 3    | 0.001082 | 0.029222 | 0.970457 | 0.998908863 | -0.05619 | 0.058357 | 1.001083 | 0.94535736  | 1.060093083 |
| GCST000712-Type 2 diabetes                                                                                                                                                            | Inverse variance weighted | 13   | -0.00228 | 0.063198 | 0.971218 | 0.998908863 | -0.12615 | 0.121588 | 0.997722 | 0.881483506 | 1.129289297 |
| GCST007385-Plasma free amino acid levels                                                                                                                                              | Inverse variance weighted | 21   | 0.000521 | 0.014563 | 0.971458 | 0.998908863 | -0.02802 | 0.029065 | 1.000521 | 0.972366241 | 1.029491374 |
| GCST000807-LDL cholesterol                                                                                                                                                            | Inverse variance weighted | 6    | 0.009977 | 0.281642 | 0.971741 | 0.998908863 | -0.54204 | 0.561996 | 1.010027 | 0.581559585 | 1.754170718 |
| GCST004257-Systolic blood pressure (long-term average)                                                                                                                                | Inverse variance weighted | 3    | -0.00054 | 0.015524 | 0.972171 | 0.998946439 | -0.03097 | 0.029885 | 0.999459 | 0.96950696  | 1.030335547 |
| GCST005194-Coronary artery disease                                                                                                                                                    | Inverse variance weighted | 76   | -0.00166 | 0.050143 | 0.973643 | 0.998946439 | -0.09994 | 0.096623 | 0.998345 | 0.904895253 | 1.101444772 |
| GCST007328-Alcohol consumption (drinks per week)                                                                                                                                      | Inverse variance weighted | 48   | -0.00618 | 0.192172 | 0.974363 | 0.998946439 | -0.38283 | 0.370482 | 0.993843 | 0.681926297 | 1.448432512 |
| GCST005235-Hand grip strength                                                                                                                                                         | Inverse variance weighted | 12   | 0.001289 | 0.041495 | 0.975226 | 0.998946439 | -0.08004 | 0.082619 | 1.001289 | 0.923078163 | 1.086127476 |
| GCST004238-Triglyceride levels                                                                                                                                                        | Inverse variance weighted | 6    | -0.00308 | 0.104406 | 0.976447 | 0.998946439 | -0.20772 | 0.201553 | 0.996922 | 0.812436654 | 1.223300471 |
| GCST000833-Psoriasis                                                                                                                                                                  | Inverse variance weighted | 5    | -0.00179 | 0.060824 | 0.976524 | 0.998946439 | -0.121   | 0.117425 | 0.998212 | 0.886030057 | 1.124596941 |
| GCST002184-Mean platelet volume                                                                                                                                                       | Inverse variance weighted | 7    | -0.00123 | 0.045361 | 0.978323 | 0.998946439 | -0.09014 | 0.087675 | 0.998768 | 0.913802759 | 1.091633817 |
| GCST004301-Prevalent atrial fibrillation                                                                                                                                              | Inverse variance weighted | 6    | -0.00146 | 0.054371 | 0.978633 | 0.998946439 | -0.10802 | 0.105111 | 0.998545 | 0.897606746 | 1.110833747 |
| GCST004280-Diastolic blood pressure                                                                                                                                                   | Inverse variance weighted | 31   | 0.000532 | 0.01991  | 0.978675 | 0.998946439 | -0.03849 | 0.039556 | 1.000532 | 0.962239974 | 1.040348574 |
| GCST000510-Hematology traits                                                                                                                                                          | Inverse variance weighted | 2    | 0.002161 | 0.081682 | 0.978897 | 0.998946439 | -0.15794 | 0.162257 | 1.002163 | 0.853904676 | 1.176162324 |
| GCST004129-White blood cell count (monocyte)                                                                                                                                          | Inverse variance weighted | 2    | -0.01842 | 0.707197 | 0.979225 | 0.998946439 | -1.40452 | 1.36769  | 0.981753 | 0.245484631 | 3.926269721 |
| GCST002023-Testicular germ cell tumor                                                                                                                                                 | Inverse variance weighted | 6    | 0.000458 | 0.019672 | 0.981413 | 0.998946439 | -0.0381  | 0.039015 | 1.000458 | 0.962618576 | 1.039785688 |
| GCST006634-Hedonic well-being                                                                                                                                                         | Inverse variance weighted | 2    | -0.01427 | 0.618156 | 0.981578 | 0.998946439 | -1.22586 | 1.197312 | 0.985828 | 0.293505446 | 3.311205053 |
| GCST003795-Age at first birth                                                                                                                                                         | Inverse variance weighted | 6    | -0.00209 | 0.094152 | 0.982283 | 0.998946439 | -0.18663 | 0.182447 | 0.997911 | 0.829752131 | 1.200150225 |
| GCST004732-Heart rate variability traits (pvRSA/HF)                                                                                                                                   | Inverse variance weighted | 5    | -0.00156 | 0.071471 | 0.982558 | 0.998946439 | -0.14165 | 0.13852  | 0.998439 | 0.867928853 | 1.148573175 |
| GCST008282-Spine bone size                                                                                                                                                            | Inverse variance weighted | 3    | -0.00505 | 0.245162 | 0.983575 | 0.998946439 | -0.48557 | 0.475471 | 0.994966 | 0.615349141 | 1.608772265 |
| GCST001893-Electrocardiographic conduction measures                                                                                                                                   | Inverse variance weighted | 4    | 0.000236 | 0.011933 | 0.984212 | 0.998946439 | -0.02315 | 0.023625 | 1.000236 | 0.977113546 | 1.023905962 |
| GCST003252-Systemic lupus erythematosus                                                                                                                                               | Inverse variance weighted | 5    | -0.00054 | 0.027701 | 0.984513 | 0.998946439 | -0.05483 | 0.053756 | 0.999462 | 0.946644486 | 1.055227348 |
| GCST007953-Glycated hemoglobin levels                                                                                                                                                 | Inverse variance weighted | 4    | 0.011766 | 0.609434 | 0.984597 | 0.998946439 | -1.18272 | 1.206257 | 1.011836 | 0.306442569 | 3.34095586  |
| GCST000397-Renal function and chronic kidney disease                                                                                                                                  | Inverse variance weighted | 2    | 0.002486 | 0.133535 | 0.985145 | 0.998946439 | -0.25924 | 0.264215 | 1.002489 | 0.771636096 | 1.302407761 |
| GCST000750-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 3    | -0.00127 | 0.069351 | 0.985397 | 0.998946439 | -0.1372  | 0.134658 | 0.998731 | 0.871798483 | 1.144145669 |
| GCST001345-Ankylosing spondylitis                                                                                                                                                     | Inverse variance weighted | 2    | 0.002131 | 0.129895 | 0.98691  | 0.998946439 | -0.25246 | 0.256724 | 1.002133 | 0.776885635 | 1.292688715 |
| GCST003764-Hirschsprung disease                                                                                                                                                       | Inverse variance weighted | 2    | -0.00042 | 0.026023 | 0.987008 | 0.998946439 | -0.05143 | 0.050582 | 0.999576 | 0.949870727 | 1.051882954 |
| GCST002878-Creutzfeldt-Jakob disease (sporadic)                                                                                                                                       | Inverse variance weighted | 2    | -0.00067 | 0.04377  | 0.987853 | 0.998946439 | -0.08646 | 0.085123 | 0.999334 | 0.91717648  | 1.088850535 |
| GCST001798-End-stage coagulation                                                                                                                                                      | Inverse variance weighted | 16   | -0.00014 | 0.009701 | 0.98811  | 0.998946439 | -0.01916 | 0.018869 | 0.999855 | 0.981024684 | 1.019047674 |
| GCST007836-Glycine levels                                                                                                                                                             | Inverse variance weighted | 7    | -0.00074 | 0.051225 | 0.988406 | 0.998946439 | -0.10115 | 0.099658 | 0.999256 | 0.903800859 | 1.104792469 |
| GCST002376-Urinary uromodulin levels                                                                                                                                                  | Inverse variance weighted | 2    | -0.00085 | 0.058806 | 0.988529 | 0.998946439 | -0.11611 | 0.114414 | 0.999155 | 0.890381704 | 1.12121627  |
| GCST007218-QT interval                                                                                                                                                                | Inverse variance weighted | 7    | -6E-05   | 0.004373 | 0.98909  | 0.998946439 | -0.00863 | 0.008512 | 0.99994  | 0.99140576  | 1.008548114 |
| GCST005217-Insulin levels adjusted for BMI                                                                                                                                            | Inverse variance weighted | 2    | -0.0021  | 0.154261 | 0.989146 | 0.998946439 | -0.30445 | 0.300254 | 0.997904 | 0.737528296 | 1.350201513 |
| GCST006804-Red cell distribution width                                                                                                                                                | Inverse variance weighted | 76   | -0.00076 | 0.057111 | 0.989415 | 0.998946439 | -0.11269 | 0.111179 | 0.999243 | 0.893423766 | 1.117594896 |
| GCST007986-Ease of getting up in the morning                                                                                                                                          | Inverse variance weighted | 41   | 0.003436 | 0.263026 | 0.989578 | 0.998946439 | -0.5121  | 0.518967 | 1.003442 | 0.599238419 | 1.680291561 |
| GCST003023-Blond vs non-blond hair color                                                                                                                                              | Inverse variance weighted | 2    | -0.00032 | 0.025003 | 0.989702 | 0.998946439 | -0.04933 | 0.048684 | 0.999677 | 0.951867604 | 1.049888428 |
| GCST001301-Schizophrenia                                                                                                                                                              | Inverse variance weighted | 2    | 0.001401 | 0.110096 | 0.989847 | 0.998946439 | -0.21439 | 0.21719  | 1.001402 | 0.807035236 | 1.242579983 |
| GCST000710-Eye color                                                                                                                                                                  | Inverse variance weighted | 4    | -8.4E-05 | 0.007586 | 0.991158 | 0.999299289 | -0.01495 | 0.014784 | 0.999916 | 0.985158878 | 1.014894045 |
| GCST003143-Lung disease severity in cystic fibrosis                                                                                                                                   | Inverse variance weighted | 2    | -0.00107 | 0.124005 | 0.993142 | 0.999299289 | -0.24412 | 0.241984 | 0.998935 | 0.783397405 | 1.273773298 |
| GCST007160-Refractive astigmatism                                                                                                                                                     | Inverse variance weighted | 2    | 0.004429 | 0.54507  | 0.993516 | 0.999299289 | -1.06391 | 1.072767 | 1.004439 | 0.345104429 | 2.923456766 |
| GCST004302-Primary biliary cholangitis                                                                                                                                                | Inverse variance weighted | 10   | 0.000176 | 0.021851 | 0.993555 | 0.999299289 | -0.04265 | 0.043004 | 1.000177 | 0.958245441 | 1.043942403 |
| GCST002874-Psoriasis                                                                                                                                                                  | Inverse variance weighted | 13   | -0.00019 | 0.025369 | 0.994006 | 0.999299289 | -0.04991 | 0.049532 | 0.999809 | 0.951312167 | 1.050779039 |
| GCST007474-Smoking initiation (ever regular vs never regular)                                                                                                                         | Inverse variance weighted | 216  | -0.00052 | 0.071916 | 0.994182 | 0.999299289 | -0.14148 | 0.140431 | 0.999476 | 0.868072941 | 1.150769413 |
| GCST000284-HDL cholesterol                                                                                                                                                            | Inverse variance weighted | 3    | -0.00097 | 0.155818 | 0.995009 | 0.999299289 | -0.30638 | 0.304428 | 0.999026 | 0.73610837  | 1.355849713 |
| GCST004133-Ulcerative colitis                                                                                                                                                         | Inverse variance weighted | 3    | -0.00086 | 0.140742 | 0.995103 | 0.999299289 | -0.27672 | 0.274991 | 0.999137 | 0.758268004 | 1.316518582 |
| GCST004449-Hepatocyte growth factor levels                                                                                                                                            | Inverse variance weighted | 2    | 0.000481 | 0.087957 | 0.995635 | 0.999299289 | -0.17191 | 0.172876 | 1.000481 | 0.842051575 | 1.188719203 |
| GCST001697-Telomere length                                                                                                                                                            | Inverse variance weighted | 4    | -0.00103 | 0.234505 | 0.99651  | 0.999495295 | -0.46066 | 0.458604 | 0.998975 | 0.630869665 | 1.581864904 |
| GCST003122-Hemoglobin levels                                                                                                                                                          | Inverse variance weighted | 2    | -0.00017 | 0.039098 | 0.996569 | 0.999495295 | -0.0768  | 0.076464 | 0.999832 | 0.926075064 | 1.079463039 |
| GCST002417-Plasma thyroid-stimulating hormone levels                                                                                                                                  | Inverse variance weighted | 2    | -0.00022 | 0.086874 | 0.997984 | 0.999913466 | -0.17049 | 0.170054 | 0.999781 | 0.84324876  | 1.185369266 |
| GCST000489-Prostate cancer                                                                                                                                                            | Inverse variance weighted | 5    | -0.00011 | 0.047922 | 0.998214 | 0.999913466 | -0.09403 | 0.093819 | 0.999893 | 0.910252151 | 1.098360985 |
| GCST007551-Behcet's disease                                                                                                                                                           | Inverse variance weighted | 2    | 2.28E-05 | 0.023165 | 0.999215 | 1           | -0.04538 | 0.045426 | 1.000023 | 0.955633752 | 1.046473687 |
| GCST004862-Itch intensity from mosquito bite adjusted by bite size                                                                                                                    | Inverse variance weighted | 20   | -0.0001  | 0.144758 | 0.999432 | 1           | -0.28383 | 0.283622 | 0.999897 | 0.752895995 | 1.327931046 |
